Table 2.
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The Associations of T2D GRS Using a Japanese Coefficient With Development of T2D

GRS LevelsNo. of Events/SubjectsModel 1Model 2Model 3
HR (95% CI)PP for TrendHR (95% CI)PP for TrendHR (95% CI)PP for Trend
Q129/2931.00 (reference)—<0.0011.00 (reference)—<0.0011.00 (reference)—<0.001
Q228/2931.00 (0.59, 1.68)0.990.99 (0.59, 1.66)0.960.96 (0.57, 1.62)0.88
Q339/2931.52 (0.94, 2.47)0.091.70 (1.05, 2.75)0.031.45 (0.89, 2.37)0.13
Q441/2931.57 (0.97, 2.53)0.061.77 (1.10, 2.87)0.021.52 (0.93, 2.47)0.09
Q562/2932.61 (1.67, 4.05)<0.0012.85 (1.83, 4.44)<0.0012.05 (1.31, 3.21)0.002
GRS LevelsNo. of Events/SubjectsModel 1Model 2Model 3
HR (95% CI)PP for TrendHR (95% CI)PP for TrendHR (95% CI)PP for Trend
Q129/2931.00 (reference)—<0.0011.00 (reference)—<0.0011.00 (reference)—<0.001
Q228/2931.00 (0.59, 1.68)0.990.99 (0.59, 1.66)0.960.96 (0.57, 1.62)0.88
Q339/2931.52 (0.94, 2.47)0.091.70 (1.05, 2.75)0.031.45 (0.89, 2.37)0.13
Q441/2931.57 (0.97, 2.53)0.061.77 (1.10, 2.87)0.021.52 (0.93, 2.47)0.09
Q562/2932.61 (1.67, 4.05)<0.0012.85 (1.83, 4.44)<0.0012.05 (1.31, 3.21)0.002

In model 1, adjustment was made for age and sex. In model 2, adjustment was made for age, sex, family history of diabetes mellitus, hypertension, serum total cholesterol, serum HDL cholesterol, serum triglycerides, use of lipid-modifying medication, BMI, smoking habits, alcohol intake, and regular exercise. In model 3, adjustment was made for covariates included in model 2 plus FPG and 2hPG.

Table 2.
Open in new tab

The Associations of T2D GRS Using a Japanese Coefficient With Development of T2D

GRS LevelsNo. of Events/SubjectsModel 1Model 2Model 3
HR (95% CI)PP for TrendHR (95% CI)PP for TrendHR (95% CI)PP for Trend
Q129/2931.00 (reference)—<0.0011.00 (reference)—<0.0011.00 (reference)—<0.001
Q228/2931.00 (0.59, 1.68)0.990.99 (0.59, 1.66)0.960.96 (0.57, 1.62)0.88
Q339/2931.52 (0.94, 2.47)0.091.70 (1.05, 2.75)0.031.45 (0.89, 2.37)0.13
Q441/2931.57 (0.97, 2.53)0.061.77 (1.10, 2.87)0.021.52 (0.93, 2.47)0.09
Q562/2932.61 (1.67, 4.05)<0.0012.85 (1.83, 4.44)<0.0012.05 (1.31, 3.21)0.002
GRS LevelsNo. of Events/SubjectsModel 1Model 2Model 3
HR (95% CI)PP for TrendHR (95% CI)PP for TrendHR (95% CI)PP for Trend
Q129/2931.00 (reference)—<0.0011.00 (reference)—<0.0011.00 (reference)—<0.001
Q228/2931.00 (0.59, 1.68)0.990.99 (0.59, 1.66)0.960.96 (0.57, 1.62)0.88
Q339/2931.52 (0.94, 2.47)0.091.70 (1.05, 2.75)0.031.45 (0.89, 2.37)0.13
Q441/2931.57 (0.97, 2.53)0.061.77 (1.10, 2.87)0.021.52 (0.93, 2.47)0.09
Q562/2932.61 (1.67, 4.05)<0.0012.85 (1.83, 4.44)<0.0012.05 (1.31, 3.21)0.002

In model 1, adjustment was made for age and sex. In model 2, adjustment was made for age, sex, family history of diabetes mellitus, hypertension, serum total cholesterol, serum HDL cholesterol, serum triglycerides, use of lipid-modifying medication, BMI, smoking habits, alcohol intake, and regular exercise. In model 3, adjustment was made for covariates included in model 2 plus FPG and 2hPG.

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