Sensitivity, specificity and F-score of DEGs identified by CellComp, RankComp, SAM, limma and RP for simulated data
FDR (%) . | Evaluation . | HepG2 . | SNU638 . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CellComp . | RankComp . | SAM . | limma . | RP . | CellComp . | RankComp . | SAM . | limma . | RP . | ||
1 | Sensitivity | 0.709 | 0.628 | 0 | 0.025 | 0 | 0.956 | 0.736 | 0.475 | 0.648 | 0 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.829 | 0.772 | 0 | 0.049 | 0 | 0.977 | 0.848 | 0.644 | 0.786 | 0 | |
5 | Sensitivity | 0.726 | 0.644 | 0.041 | 0.197 | 0.015 | 0.965 | 0.744 | 0.635 | 0.878 | 0.288 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.842 | 0.784 | 0.079 | 0.328 | 0.029 | 0.982 | 0.853 | 0.777 | 0.935 | 0.447 | |
10 | Sensitivity | 0.798 | 0.755 | 0.345 | 0.393 | 0.058 | 0.970 | 0.755 | 0.802 | 0.936 | 0.506 |
Specificity | 1 | 1 | 0.994 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.888 | 0.860 | 0.508 | 0.564 | 0.109 | 0.984 | 0.860 | 0.890 | 0.967 | 0.672 |
FDR (%) . | Evaluation . | HepG2 . | SNU638 . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CellComp . | RankComp . | SAM . | limma . | RP . | CellComp . | RankComp . | SAM . | limma . | RP . | ||
1 | Sensitivity | 0.709 | 0.628 | 0 | 0.025 | 0 | 0.956 | 0.736 | 0.475 | 0.648 | 0 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.829 | 0.772 | 0 | 0.049 | 0 | 0.977 | 0.848 | 0.644 | 0.786 | 0 | |
5 | Sensitivity | 0.726 | 0.644 | 0.041 | 0.197 | 0.015 | 0.965 | 0.744 | 0.635 | 0.878 | 0.288 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.842 | 0.784 | 0.079 | 0.328 | 0.029 | 0.982 | 0.853 | 0.777 | 0.935 | 0.447 | |
10 | Sensitivity | 0.798 | 0.755 | 0.345 | 0.393 | 0.058 | 0.970 | 0.755 | 0.802 | 0.936 | 0.506 |
Specificity | 1 | 1 | 0.994 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.888 | 0.860 | 0.508 | 0.564 | 0.109 | 0.984 | 0.860 | 0.890 | 0.967 | 0.672 |
Sensitivity, specificity and F-score of DEGs identified by CellComp, RankComp, SAM, limma and RP for simulated data
FDR (%) . | Evaluation . | HepG2 . | SNU638 . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CellComp . | RankComp . | SAM . | limma . | RP . | CellComp . | RankComp . | SAM . | limma . | RP . | ||
1 | Sensitivity | 0.709 | 0.628 | 0 | 0.025 | 0 | 0.956 | 0.736 | 0.475 | 0.648 | 0 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.829 | 0.772 | 0 | 0.049 | 0 | 0.977 | 0.848 | 0.644 | 0.786 | 0 | |
5 | Sensitivity | 0.726 | 0.644 | 0.041 | 0.197 | 0.015 | 0.965 | 0.744 | 0.635 | 0.878 | 0.288 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.842 | 0.784 | 0.079 | 0.328 | 0.029 | 0.982 | 0.853 | 0.777 | 0.935 | 0.447 | |
10 | Sensitivity | 0.798 | 0.755 | 0.345 | 0.393 | 0.058 | 0.970 | 0.755 | 0.802 | 0.936 | 0.506 |
Specificity | 1 | 1 | 0.994 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.888 | 0.860 | 0.508 | 0.564 | 0.109 | 0.984 | 0.860 | 0.890 | 0.967 | 0.672 |
FDR (%) . | Evaluation . | HepG2 . | SNU638 . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CellComp . | RankComp . | SAM . | limma . | RP . | CellComp . | RankComp . | SAM . | limma . | RP . | ||
1 | Sensitivity | 0.709 | 0.628 | 0 | 0.025 | 0 | 0.956 | 0.736 | 0.475 | 0.648 | 0 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.829 | 0.772 | 0 | 0.049 | 0 | 0.977 | 0.848 | 0.644 | 0.786 | 0 | |
5 | Sensitivity | 0.726 | 0.644 | 0.041 | 0.197 | 0.015 | 0.965 | 0.744 | 0.635 | 0.878 | 0.288 |
Specificity | 1 | 1 | 1 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.842 | 0.784 | 0.079 | 0.328 | 0.029 | 0.982 | 0.853 | 0.777 | 0.935 | 0.447 | |
10 | Sensitivity | 0.798 | 0.755 | 0.345 | 0.393 | 0.058 | 0.970 | 0.755 | 0.802 | 0.936 | 0.506 |
Specificity | 1 | 1 | 0.994 | 1 | 1 | 0.999 | 0.999 | 1 | 1 | 1 | |
F-score | 0.888 | 0.860 | 0.508 | 0.564 | 0.109 | 0.984 | 0.860 | 0.890 | 0.967 | 0.672 |
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