Table 7. Open in new tab HRs for the...

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	12,678	17,056,868	0.7	1 (reference)	1 (reference)	1 (reference)
MUNO	6611	5,171,781	1.3	1.38 (1.34–1.43)	1.19 (1.16–1.23)	1.19 (1.16–1.23)
MHO	3601	5,356,227	0.7	0.90 (0.87–0.94)	0.88 (0.85–0.91)	0.90 (0.87–0.93)
MUO	7188	6,962,901	1.0	1.71 (1.66–1.76)	1.42 (1.28–1.46)	1.41 (1.37–1.45)
AD
MHNO	7903	17,056,868	0.5	1 (reference)	1 (reference)	1 (reference)
MUNO	3967	5,171,781	0.8	1.31 (1.26–1.36)	1.11 (1.07–1.16)	1.11 (1.07–1.16)
MHO	2184	5,356,227	0.4	0.88 (0.84–0.92)	0.86 (0.82–0.90)	0.88 (0.83–0.92)
MUO	4252	6,962,901	0.6	1.65 (1.58–1.71)	1.33 (1.28–1.38)	1.33 (1.28–1.38)
VaD
MHNO	2437	17,056,868	0.1	1 (reference)	1 (reference)	1 (reference)
MUNO	1467	5,171,781	0.3	1.72 (1.61–1.83)	1.52 (1.43–1.62)	1.53 (1.44–1.63)
MHO	769	5,356,227	0.1	1.00 (0.92–1.08)	0.97 (0.89–1.05)	0.99 (0.92–1.08)
MUO	1713	6,962,901	0.2	1.98 (1.85–2.11)	1.73 (1.62–1.84)	1.71 (1.60–1.82)

Group

Incident Cases, n

Person-Years, n

Incident Rate^a

Model 1^b

Model 2^c

Model 3^d

Overall dementia

MHNO

12,678

17,056,868

0.7

1 (reference)

MUNO

6611

5,171,781

1.3

1.38 (1.34–1.43)

1.19 (1.16–1.23)

MHO

3601

5,356,227

0.7

0.90 (0.87–0.94)

0.88 (0.85–0.91)

0.90 (0.87–0.93)

MUO

7188

6,962,901

1.0

1.71 (1.66–1.76)

1.42 (1.28–1.46)

1.41 (1.37–1.45)

MHNO

7903

17,056,868

0.5

1 (reference)

MUNO

3967

5,171,781

0.8

1.31 (1.26–1.36)

1.11 (1.07–1.16)

MHO

2184

5,356,227

0.4

0.88 (0.84–0.92)

0.86 (0.82–0.90)

0.88 (0.83–0.92)

MUO

4252

6,962,901

0.6

1.65 (1.58–1.71)

1.33 (1.28–1.38)

VaD

MHNO

2437

17,056,868

0.1

1 (reference)

MUNO

1467

5,171,781

0.3

1.72 (1.61–1.83)

1.52 (1.43–1.62)

1.53 (1.44–1.63)

MHO

769

5,356,227

0.1

1.00 (0.92–1.08)

0.97 (0.89–1.05)

0.99 (0.92–1.08)

MUO

1713

6,962,901

0.2

1.98 (1.85–2.11)

1.73 (1.62–1.84)

1.71 (1.60–1.82)

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	12,678	17,056,868	0.7	1 (reference)	1 (reference)	1 (reference)
MUNO	6611	5,171,781	1.3	1.38 (1.34–1.43)	1.19 (1.16–1.23)	1.19 (1.16–1.23)
MHO	3601	5,356,227	0.7	0.90 (0.87–0.94)	0.88 (0.85–0.91)	0.90 (0.87–0.93)
MUO	7188	6,962,901	1.0	1.71 (1.66–1.76)	1.42 (1.28–1.46)	1.41 (1.37–1.45)
AD
MHNO	7903	17,056,868	0.5	1 (reference)	1 (reference)	1 (reference)
MUNO	3967	5,171,781	0.8	1.31 (1.26–1.36)	1.11 (1.07–1.16)	1.11 (1.07–1.16)
MHO	2184	5,356,227	0.4	0.88 (0.84–0.92)	0.86 (0.82–0.90)	0.88 (0.83–0.92)
MUO	4252	6,962,901	0.6	1.65 (1.58–1.71)	1.33 (1.28–1.38)	1.33 (1.28–1.38)
VaD
MHNO	2437	17,056,868	0.1	1 (reference)	1 (reference)	1 (reference)
MUNO	1467	5,171,781	0.3	1.72 (1.61–1.83)	1.52 (1.43–1.62)	1.53 (1.44–1.63)
MHO	769	5,356,227	0.1	1.00 (0.92–1.08)	0.97 (0.89–1.05)	0.99 (0.92–1.08)
MUO	1713	6,962,901	0.2	1.98 (1.85–2.11)	1.73 (1.62–1.84)	1.71 (1.60–1.82)

Table 7.

Open in new tab

HRs for the Development of Dementia According to Metabolic Health and Obesity Status in Subjects Aged 50 to 60 Years

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	12,678	17,056,868	0.7	1 (reference)	1 (reference)	1 (reference)
MUNO	6611	5,171,781	1.3	1.38 (1.34–1.43)	1.19 (1.16–1.23)	1.19 (1.16–1.23)
MHO	3601	5,356,227	0.7	0.90 (0.87–0.94)	0.88 (0.85–0.91)	0.90 (0.87–0.93)
MUO	7188	6,962,901	1.0	1.71 (1.66–1.76)	1.42 (1.28–1.46)	1.41 (1.37–1.45)
AD
MHNO	7903	17,056,868	0.5	1 (reference)	1 (reference)	1 (reference)
MUNO	3967	5,171,781	0.8	1.31 (1.26–1.36)	1.11 (1.07–1.16)	1.11 (1.07–1.16)
MHO	2184	5,356,227	0.4	0.88 (0.84–0.92)	0.86 (0.82–0.90)	0.88 (0.83–0.92)
MUO	4252	6,962,901	0.6	1.65 (1.58–1.71)	1.33 (1.28–1.38)	1.33 (1.28–1.38)
VaD
MHNO	2437	17,056,868	0.1	1 (reference)	1 (reference)	1 (reference)
MUNO	1467	5,171,781	0.3	1.72 (1.61–1.83)	1.52 (1.43–1.62)	1.53 (1.44–1.63)
MHO	769	5,356,227	0.1	1.00 (0.92–1.08)	0.97 (0.89–1.05)	0.99 (0.92–1.08)
MUO	1713	6,962,901	0.2	1.98 (1.85–2.11)	1.73 (1.62–1.84)	1.71 (1.60–1.82)

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	12,678	17,056,868	0.7	1 (reference)	1 (reference)	1 (reference)
MUNO	6611	5,171,781	1.3	1.38 (1.34–1.43)	1.19 (1.16–1.23)	1.19 (1.16–1.23)
MHO	3601	5,356,227	0.7	0.90 (0.87–0.94)	0.88 (0.85–0.91)	0.90 (0.87–0.93)
MUO	7188	6,962,901	1.0	1.71 (1.66–1.76)	1.42 (1.28–1.46)	1.41 (1.37–1.45)
AD
MHNO	7903	17,056,868	0.5	1 (reference)	1 (reference)	1 (reference)
MUNO	3967	5,171,781	0.8	1.31 (1.26–1.36)	1.11 (1.07–1.16)	1.11 (1.07–1.16)
MHO	2184	5,356,227	0.4	0.88 (0.84–0.92)	0.86 (0.82–0.90)	0.88 (0.83–0.92)
MUO	4252	6,962,901	0.6	1.65 (1.58–1.71)	1.33 (1.28–1.38)	1.33 (1.28–1.38)
VaD
MHNO	2437	17,056,868	0.1	1 (reference)	1 (reference)	1 (reference)
MUNO	1467	5,171,781	0.3	1.72 (1.61–1.83)	1.52 (1.43–1.62)	1.53 (1.44–1.63)
MHO	769	5,356,227	0.1	1.00 (0.92–1.08)	0.97 (0.89–1.05)	0.99 (0.92–1.08)
MUO	1713	6,962,901	0.2	1.98 (1.85–2.11)	1.73 (1.62–1.84)	1.71 (1.60–1.82)

Values with statistical significance are bold.

Incident rate for 1000 person-years.

Unadjusted.

Adjusted for age and sex.

Further adjusted for tobacco and alcohol use, exercise, socioeconomic status, and LDL-C.

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