Table 3. Open in new tab Contribution of...

Group	Without Modifiable Risk Factors^a	With Modifiable Risk Factors^b
Overall dementia
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.07 (1.06–1.09)	1.05 (1.03–1.07)	0.77 (0.68–0.86)	1.00 (0.89–1.12)
MHO	0.79 (0.77–0.81)	0.89 (0.87–0.92)	0.65 (0.53–0.79)	0.81 (0.67–0.98)
MUO	1.42 (1.40–1.44)	1.18 (1.16–1.20)	1.23 (1.14–1.33)	1.32 (1.23–1.43)
AD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.03 (1.01–1.05)	1.00 (0.98–1.03)	0.75 (0.65–0.86)	1.00 (0.87–1.15)
MHO	0.78 (0.76–0.80)	0.88 (0.86–0.91)	0.55 (0.43–0.71)	0.71 (0.55–0.91)
MUO	1.39 (1.37–1.42)	1.15 (1.13–1.17)	1.17 (1.06–1.28)	1.26 (1.15–1.38)
VaD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.41 (1.34–1.48)	1.39 (1.32–1.46)	0.97 (0.74–1.27)	1.19 (0.91–1.56)
MHO	0.97 (0.90–1.04)	1.07 (1.00–1.15)	0.77 (0.48–1.22)	0.91 (0.57–1.45)
MUO	1.66 (1.58–1.74)	1.43 (1.37–1.51)	1.44 (1.19–1.75)	1.52 (1.25–1.85)

Group

Without Modifiable Risk Factors^a

With Modifiable Risk Factors^b

Model 1^c

Model 2^d

Model 1^c

Model 2^d

Overall dementia

MHNO

1 (reference)

MUNO

1.07 (1.06–1.09)

1.05 (1.03–1.07)

0.77 (0.68–0.86)

1.00 (0.89–1.12)

MHO

0.79 (0.77–0.81)

0.89 (0.87–0.92)

0.65 (0.53–0.79)

0.81 (0.67–0.98)

MUO

1.42 (1.40–1.44)

1.18 (1.16–1.20)

1.23 (1.14–1.33)

1.32 (1.23–1.43)

MHNO

1 (reference)

MUNO

1.03 (1.01–1.05)

1.00 (0.98–1.03)

0.75 (0.65–0.86)

1.00 (0.87–1.15)

MHO

0.78 (0.76–0.80)

0.88 (0.86–0.91)

0.55 (0.43–0.71)

0.71 (0.55–0.91)

MUO

1.39 (1.37–1.42)

1.15 (1.13–1.17)

1.17 (1.06–1.28)

1.26 (1.15–1.38)

VaD

MHNO

1 (reference)

MUNO

1.41 (1.34–1.48)

1.39 (1.32–1.46)

0.97 (0.74–1.27)

1.19 (0.91–1.56)

MHO

0.97 (0.90–1.04)

1.07 (1.00–1.15)

0.77 (0.48–1.22)

0.91 (0.57–1.45)

MUO

1.66 (1.58–1.74)

1.43 (1.37–1.51)

1.44 (1.19–1.75)

1.52 (1.25–1.85)

Group	Without Modifiable Risk Factors^a	With Modifiable Risk Factors^b
Overall dementia
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.07 (1.06–1.09)	1.05 (1.03–1.07)	0.77 (0.68–0.86)	1.00 (0.89–1.12)
MHO	0.79 (0.77–0.81)	0.89 (0.87–0.92)	0.65 (0.53–0.79)	0.81 (0.67–0.98)
MUO	1.42 (1.40–1.44)	1.18 (1.16–1.20)	1.23 (1.14–1.33)	1.32 (1.23–1.43)
AD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.03 (1.01–1.05)	1.00 (0.98–1.03)	0.75 (0.65–0.86)	1.00 (0.87–1.15)
MHO	0.78 (0.76–0.80)	0.88 (0.86–0.91)	0.55 (0.43–0.71)	0.71 (0.55–0.91)
MUO	1.39 (1.37–1.42)	1.15 (1.13–1.17)	1.17 (1.06–1.28)	1.26 (1.15–1.38)
VaD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.41 (1.34–1.48)	1.39 (1.32–1.46)	0.97 (0.74–1.27)	1.19 (0.91–1.56)
MHO	0.97 (0.90–1.04)	1.07 (1.00–1.15)	0.77 (0.48–1.22)	0.91 (0.57–1.45)
MUO	1.66 (1.58–1.74)	1.43 (1.37–1.51)	1.44 (1.19–1.75)	1.52 (1.25–1.85)

Table 3.

Open in new tab

Contribution of Metabolic Health and Obesity Status on the Development of Dementia According to the Presence of Modifiable Risk Factors

Group	Without Modifiable Risk Factors^a		With Modifiable Risk Factors^b
Group	Model 1^c	Model 2^d	Model 1^c	Model 2^d
Overall dementia
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.07 (1.06–1.09)	1.05 (1.03–1.07)	0.77 (0.68–0.86)	1.00 (0.89–1.12)
MHO	0.79 (0.77–0.81)	0.89 (0.87–0.92)	0.65 (0.53–0.79)	0.81 (0.67–0.98)
MUO	1.42 (1.40–1.44)	1.18 (1.16–1.20)	1.23 (1.14–1.33)	1.32 (1.23–1.43)
AD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.03 (1.01–1.05)	1.00 (0.98–1.03)	0.75 (0.65–0.86)	1.00 (0.87–1.15)
MHO	0.78 (0.76–0.80)	0.88 (0.86–0.91)	0.55 (0.43–0.71)	0.71 (0.55–0.91)
MUO	1.39 (1.37–1.42)	1.15 (1.13–1.17)	1.17 (1.06–1.28)	1.26 (1.15–1.38)
VaD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.41 (1.34–1.48)	1.39 (1.32–1.46)	0.97 (0.74–1.27)	1.19 (0.91–1.56)
MHO	0.97 (0.90–1.04)	1.07 (1.00–1.15)	0.77 (0.48–1.22)	0.91 (0.57–1.45)
MUO	1.66 (1.58–1.74)	1.43 (1.37–1.51)	1.44 (1.19–1.75)	1.52 (1.25–1.85)

Group	Without Modifiable Risk Factors^a		With Modifiable Risk Factors^b
Group	Model 1^c	Model 2^d	Model 1^c	Model 2^d
Overall dementia
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.07 (1.06–1.09)	1.05 (1.03–1.07)	0.77 (0.68–0.86)	1.00 (0.89–1.12)
MHO	0.79 (0.77–0.81)	0.89 (0.87–0.92)	0.65 (0.53–0.79)	0.81 (0.67–0.98)
MUO	1.42 (1.40–1.44)	1.18 (1.16–1.20)	1.23 (1.14–1.33)	1.32 (1.23–1.43)
AD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.03 (1.01–1.05)	1.00 (0.98–1.03)	0.75 (0.65–0.86)	1.00 (0.87–1.15)
MHO	0.78 (0.76–0.80)	0.88 (0.86–0.91)	0.55 (0.43–0.71)	0.71 (0.55–0.91)
MUO	1.39 (1.37–1.42)	1.15 (1.13–1.17)	1.17 (1.06–1.28)	1.26 (1.15–1.38)
VaD
MHNO	1 (reference)	1 (reference)	1 (reference)	1 (reference)
MUNO	1.41 (1.34–1.48)	1.39 (1.32–1.46)	0.97 (0.74–1.27)	1.19 (0.91–1.56)
MHO	0.97 (0.90–1.04)	1.07 (1.00–1.15)	0.77 (0.48–1.22)	0.91 (0.57–1.45)
MUO	1.66 (1.58–1.74)	1.43 (1.37–1.51)	1.44 (1.19–1.75)	1.52 (1.25–1.85)

Values with statistical significance are bold.

Subjects of noncurrent smoker, not heavy drinker, and physically active.

Subjects of current smoker, heavy drinker, and not physically active.

Unadjusted.

Adjusted for age, sex, socioeconomic status, and LDL-C.

This Feature Is Available To Subscribers Only