Table 2. Open in new tab HRs for the...

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	99,538	8,928,576	11.1	1 (reference)	1 (reference)	1 (reference)
MUNO	150,341	9,386,923	16.0	1.44 (1.43–1.45)	1.20 (1.19–1.21)	1.16 (1.15–1.17)
MHO	27,675	3,364,116	8.2	0.74 (0.73–0.75)	0.86 (0.84–0.87)	0.85 (0.84–0.86)
MUO	86,378	7,409,687	11.7	1.05 (1.04–1.06)	1.04 (1.03–1.05)	1.01 (0.99–1.02)
AD
MHNO	74,340	8,928,576	8.3	1 (reference)	1 (reference)	1 (reference)
MUNO	110,318	9,386,923	11.8	1.41 (1.40–1.43)	1.16 (1.15–1.18)	1.38 (1.35–1.42)
MHO	20,254	3,364,116	6.0	0.72 (0.71–0.73)	0.84 (0.83–0.85)	0.87 (0.86–0.88)
MUO	62,456	7,409,687	8.4	1.01 (1.00–1.02)	1.00 (0.99–1.02)	1.29 (1.25–1.32)
VaD
MHNO	10,701	8,928,576	1.2	1 (reference)	1 (reference)	1 (reference)
MUNO	18,235	9,386,923	1.9	1.62 (1.59–1.66)	1.42 (1.38–1.45)	1.41 (1.38–1.44)
MHO	3,487	3,364,116	1.0	0.86 (0.83–0.90)	0.99 (0.96–1.03)	1.02 (0.98–1.06)
MUO	11,495	7,409,687	1.6	1.29 (1.26–1.33)	1.32 (1.28–1.35)	1.33 (1.29–1.36)

Group

Incident Cases, n

Person-Years, n

Incident Rate^a

Model 1^b

Model 2^c

Model 3^d

Overall dementia

MHNO

99,538

8,928,576

11.1

1 (reference)

MUNO

150,341

9,386,923

16.0

1.44 (1.43–1.45)

1.20 (1.19–1.21)

1.16 (1.15–1.17)

MHO

27,675

3,364,116

8.2

0.74 (0.73–0.75)

0.86 (0.84–0.87)

0.85 (0.84–0.86)

MUO

86,378

7,409,687

11.7

1.05 (1.04–1.06)

1.04 (1.03–1.05)

1.01 (0.99–1.02)

MHNO

74,340

8,928,576

8.3

1 (reference)

MUNO

110,318

9,386,923

11.8

1.41 (1.40–1.43)

1.16 (1.15–1.18)

1.38 (1.35–1.42)

MHO

20,254

3,364,116

6.0

0.72 (0.71–0.73)

0.84 (0.83–0.85)

0.87 (0.86–0.88)

MUO

62,456

7,409,687

8.4

1.01 (1.00–1.02)

1.00 (0.99–1.02)

1.29 (1.25–1.32)

VaD

MHNO

10,701

8,928,576

1.2

1 (reference)

MUNO

18,235

9,386,923

1.9

1.62 (1.59–1.66)

1.42 (1.38–1.45)

1.41 (1.38–1.44)

MHO

3,487

3,364,116

1.0

0.86 (0.83–0.90)

0.99 (0.96–1.03)

1.02 (0.98–1.06)

MUO

11,495

7,409,687

1.6

1.29 (1.26–1.33)

1.32 (1.28–1.35)

1.33 (1.29–1.36)

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	99,538	8,928,576	11.1	1 (reference)	1 (reference)	1 (reference)
MUNO	150,341	9,386,923	16.0	1.44 (1.43–1.45)	1.20 (1.19–1.21)	1.16 (1.15–1.17)
MHO	27,675	3,364,116	8.2	0.74 (0.73–0.75)	0.86 (0.84–0.87)	0.85 (0.84–0.86)
MUO	86,378	7,409,687	11.7	1.05 (1.04–1.06)	1.04 (1.03–1.05)	1.01 (0.99–1.02)
AD
MHNO	74,340	8,928,576	8.3	1 (reference)	1 (reference)	1 (reference)
MUNO	110,318	9,386,923	11.8	1.41 (1.40–1.43)	1.16 (1.15–1.18)	1.38 (1.35–1.42)
MHO	20,254	3,364,116	6.0	0.72 (0.71–0.73)	0.84 (0.83–0.85)	0.87 (0.86–0.88)
MUO	62,456	7,409,687	8.4	1.01 (1.00–1.02)	1.00 (0.99–1.02)	1.29 (1.25–1.32)
VaD
MHNO	10,701	8,928,576	1.2	1 (reference)	1 (reference)	1 (reference)
MUNO	18,235	9,386,923	1.9	1.62 (1.59–1.66)	1.42 (1.38–1.45)	1.41 (1.38–1.44)
MHO	3,487	3,364,116	1.0	0.86 (0.83–0.90)	0.99 (0.96–1.03)	1.02 (0.98–1.06)
MUO	11,495	7,409,687	1.6	1.29 (1.26–1.33)	1.32 (1.28–1.35)	1.33 (1.29–1.36)

Table 2.

Open in new tab

HRs for the Development of Dementia According to Metabolic Health and Obesity Status

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	99,538	8,928,576	11.1	1 (reference)	1 (reference)	1 (reference)
MUNO	150,341	9,386,923	16.0	1.44 (1.43–1.45)	1.20 (1.19–1.21)	1.16 (1.15–1.17)
MHO	27,675	3,364,116	8.2	0.74 (0.73–0.75)	0.86 (0.84–0.87)	0.85 (0.84–0.86)
MUO	86,378	7,409,687	11.7	1.05 (1.04–1.06)	1.04 (1.03–1.05)	1.01 (0.99–1.02)
AD
MHNO	74,340	8,928,576	8.3	1 (reference)	1 (reference)	1 (reference)
MUNO	110,318	9,386,923	11.8	1.41 (1.40–1.43)	1.16 (1.15–1.18)	1.38 (1.35–1.42)
MHO	20,254	3,364,116	6.0	0.72 (0.71–0.73)	0.84 (0.83–0.85)	0.87 (0.86–0.88)
MUO	62,456	7,409,687	8.4	1.01 (1.00–1.02)	1.00 (0.99–1.02)	1.29 (1.25–1.32)
VaD
MHNO	10,701	8,928,576	1.2	1 (reference)	1 (reference)	1 (reference)
MUNO	18,235	9,386,923	1.9	1.62 (1.59–1.66)	1.42 (1.38–1.45)	1.41 (1.38–1.44)
MHO	3,487	3,364,116	1.0	0.86 (0.83–0.90)	0.99 (0.96–1.03)	1.02 (0.98–1.06)
MUO	11,495	7,409,687	1.6	1.29 (1.26–1.33)	1.32 (1.28–1.35)	1.33 (1.29–1.36)

Group	Incident Cases, n	Person-Years, n	Incident Rate^a	Model 1^b	Model 2^c	Model 3^d
Overall dementia
MHNO	99,538	8,928,576	11.1	1 (reference)	1 (reference)	1 (reference)
MUNO	150,341	9,386,923	16.0	1.44 (1.43–1.45)	1.20 (1.19–1.21)	1.16 (1.15–1.17)
MHO	27,675	3,364,116	8.2	0.74 (0.73–0.75)	0.86 (0.84–0.87)	0.85 (0.84–0.86)
MUO	86,378	7,409,687	11.7	1.05 (1.04–1.06)	1.04 (1.03–1.05)	1.01 (0.99–1.02)
AD
MHNO	74,340	8,928,576	8.3	1 (reference)	1 (reference)	1 (reference)
MUNO	110,318	9,386,923	11.8	1.41 (1.40–1.43)	1.16 (1.15–1.18)	1.38 (1.35–1.42)
MHO	20,254	3,364,116	6.0	0.72 (0.71–0.73)	0.84 (0.83–0.85)	0.87 (0.86–0.88)
MUO	62,456	7,409,687	8.4	1.01 (1.00–1.02)	1.00 (0.99–1.02)	1.29 (1.25–1.32)
VaD
MHNO	10,701	8,928,576	1.2	1 (reference)	1 (reference)	1 (reference)
MUNO	18,235	9,386,923	1.9	1.62 (1.59–1.66)	1.42 (1.38–1.45)	1.41 (1.38–1.44)
MHO	3,487	3,364,116	1.0	0.86 (0.83–0.90)	0.99 (0.96–1.03)	1.02 (0.98–1.06)
MUO	11,495	7,409,687	1.6	1.29 (1.26–1.33)	1.32 (1.28–1.35)	1.33 (1.29–1.36)

Values with statistical significance are bold.

Incident rate for 1000 person-years.

Unadjusted.

Adjusted for age and sex.

Further adjusted for tobacco and alcohol use, exercise, socioeconomic status, and LDL-C.

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