Baseline Characteristics of Study Subjects According to Metabolic Health and Obesity
| Characteristic . | Nonobese (n = 3,590,919) . | Obese (n = 2,078,569) . | ||
|---|---|---|---|---|
| MHNO (n = 1,738,074) . | MUNO (n = 1,852,845) . | MHO (n = 644,447) . | MUO (n = 1,434,122) . | |
| Age, y | 66.8 ± 6.4 | 68.1 ± 6.8 | 65.8 ± 5.6 | 66.9 ± 6.0 |
| Male sex | 867,637 (49.9) | 865,703 (46.7) | 263,261 (40.9) | 595,782 (41.5) |
| Height, cm | 158.9 ± 8.6 | 158.3 ± 8.8 | 157.7 ± 8.6 | 157.8 ± 8.8 |
| Weight, kg | 55.6 ± 7.9 | 56.8 ± 8.0 | 67.3 ± 8.1 | 68.4 ± 8.6 |
| BMI, kg/m2 | 22.0 ± 2.0 | 22.6 ± 1.8 | 27.0 ± 1.8 | 27.4 ± 2.1 |
| Systolic BP, mm Hg | 122.3 ± 14.8 | 132.0 ± 15.6 | 126.1 ± 14.7 | 133.6 ± 15.2 |
| Diastolic BP, mm Hg | 75.0 ± 9.5 | 79.4 ± 9.9 | 77.2 ± 9.5 | 80.5 ± 9.8 |
| Fasting glucose, mg/dL | 92.8 ± 16.0 | 111.0 ± 30.9 | 93.1 ± 14.4 | 112.0 ± 29.6 |
| Total cholesterol, mg/dL | 196.6 ± 36.2 | 197.5 ± 40.4 | 201.6 ± 36.9 | 200.4 ± 40.6 |
| TG, mg/dL | 98.3 ± 42.5 | 163.2 ± 93.9 | 106.4 ± 43.7 | 175.2 ± 95.4 |
| HDL-C, mg/dL | 59.0 ± 17.7 | 50.3 ± 17.7 | 57.7 ± 17.3 | 49.2 ± 17.0 |
| LDL-C, mg/dL | 118.2 ± 33.4 | 115.4 ± 36.9 | 122.8 ± 34.3 | 117.1 ± 37.4 |
| Current smoker | 285,388 (16.4) | 293,240 (15.8) | 59,865 (9.3) | 150,405 (10.5) |
| Heavy drinker | 68,470 (3.9) | 92,641 (5.0) | 20,785 (3.2) | 61,843 (4.3) |
| Exercise | 759,858 (43.7) | 750,817 (40.5) | 284,349 (44.1) | 585,875 (40.9) |
| Low socioeconomic status | 384,236 (22.1) | 414,186 (22.4) | 139,787 (21.7) | 315,948 (22.0) |
| Comorbidities | ||||
| Hypertension | 484,857 (27.9) | 1,234,184 (66.6) | 262,942 (40.8) | 1,086,237 (75.7) |
| Diabetes | 75,192 (4.3) | 539,691 (29.1) | 26,257 (4.1) | 469,584 (32.7) |
| Hyperlipidemia | 149,566 (8.6) | 253,593 (13.7) | 67,287 (10.4) | 212,404 (14.8) |
| CKD | 162,082 (9.3) | 285,461 (15.4) | 72,966 (11.3) | 247,832 (17.3) |
| Previous myocardial infarction | 77,872 (4.5) | 127,374 (6.9) | 37,534 (5.8) | 116,146 (8.1) |
| Previous ischemic stroke | 80,878 (4.7) | 144,502 (7.8) | 33,838 (5.3) | 111,809 (7.8) |
| Characteristic . | Nonobese (n = 3,590,919) . | Obese (n = 2,078,569) . | ||
|---|---|---|---|---|
| MHNO (n = 1,738,074) . | MUNO (n = 1,852,845) . | MHO (n = 644,447) . | MUO (n = 1,434,122) . | |
| Age, y | 66.8 ± 6.4 | 68.1 ± 6.8 | 65.8 ± 5.6 | 66.9 ± 6.0 |
| Male sex | 867,637 (49.9) | 865,703 (46.7) | 263,261 (40.9) | 595,782 (41.5) |
| Height, cm | 158.9 ± 8.6 | 158.3 ± 8.8 | 157.7 ± 8.6 | 157.8 ± 8.8 |
| Weight, kg | 55.6 ± 7.9 | 56.8 ± 8.0 | 67.3 ± 8.1 | 68.4 ± 8.6 |
| BMI, kg/m2 | 22.0 ± 2.0 | 22.6 ± 1.8 | 27.0 ± 1.8 | 27.4 ± 2.1 |
| Systolic BP, mm Hg | 122.3 ± 14.8 | 132.0 ± 15.6 | 126.1 ± 14.7 | 133.6 ± 15.2 |
| Diastolic BP, mm Hg | 75.0 ± 9.5 | 79.4 ± 9.9 | 77.2 ± 9.5 | 80.5 ± 9.8 |
| Fasting glucose, mg/dL | 92.8 ± 16.0 | 111.0 ± 30.9 | 93.1 ± 14.4 | 112.0 ± 29.6 |
| Total cholesterol, mg/dL | 196.6 ± 36.2 | 197.5 ± 40.4 | 201.6 ± 36.9 | 200.4 ± 40.6 |
| TG, mg/dL | 98.3 ± 42.5 | 163.2 ± 93.9 | 106.4 ± 43.7 | 175.2 ± 95.4 |
| HDL-C, mg/dL | 59.0 ± 17.7 | 50.3 ± 17.7 | 57.7 ± 17.3 | 49.2 ± 17.0 |
| LDL-C, mg/dL | 118.2 ± 33.4 | 115.4 ± 36.9 | 122.8 ± 34.3 | 117.1 ± 37.4 |
| Current smoker | 285,388 (16.4) | 293,240 (15.8) | 59,865 (9.3) | 150,405 (10.5) |
| Heavy drinker | 68,470 (3.9) | 92,641 (5.0) | 20,785 (3.2) | 61,843 (4.3) |
| Exercise | 759,858 (43.7) | 750,817 (40.5) | 284,349 (44.1) | 585,875 (40.9) |
| Low socioeconomic status | 384,236 (22.1) | 414,186 (22.4) | 139,787 (21.7) | 315,948 (22.0) |
| Comorbidities | ||||
| Hypertension | 484,857 (27.9) | 1,234,184 (66.6) | 262,942 (40.8) | 1,086,237 (75.7) |
| Diabetes | 75,192 (4.3) | 539,691 (29.1) | 26,257 (4.1) | 469,584 (32.7) |
| Hyperlipidemia | 149,566 (8.6) | 253,593 (13.7) | 67,287 (10.4) | 212,404 (14.8) |
| CKD | 162,082 (9.3) | 285,461 (15.4) | 72,966 (11.3) | 247,832 (17.3) |
| Previous myocardial infarction | 77,872 (4.5) | 127,374 (6.9) | 37,534 (5.8) | 116,146 (8.1) |
| Previous ischemic stroke | 80,878 (4.7) | 144,502 (7.8) | 33,838 (5.3) | 111,809 (7.8) |
Values are presented as mean (SD) for continuous variables and n (%) for categorical variables.
Baseline Characteristics of Study Subjects According to Metabolic Health and Obesity
| Characteristic . | Nonobese (n = 3,590,919) . | Obese (n = 2,078,569) . | ||
|---|---|---|---|---|
| MHNO (n = 1,738,074) . | MUNO (n = 1,852,845) . | MHO (n = 644,447) . | MUO (n = 1,434,122) . | |
| Age, y | 66.8 ± 6.4 | 68.1 ± 6.8 | 65.8 ± 5.6 | 66.9 ± 6.0 |
| Male sex | 867,637 (49.9) | 865,703 (46.7) | 263,261 (40.9) | 595,782 (41.5) |
| Height, cm | 158.9 ± 8.6 | 158.3 ± 8.8 | 157.7 ± 8.6 | 157.8 ± 8.8 |
| Weight, kg | 55.6 ± 7.9 | 56.8 ± 8.0 | 67.3 ± 8.1 | 68.4 ± 8.6 |
| BMI, kg/m2 | 22.0 ± 2.0 | 22.6 ± 1.8 | 27.0 ± 1.8 | 27.4 ± 2.1 |
| Systolic BP, mm Hg | 122.3 ± 14.8 | 132.0 ± 15.6 | 126.1 ± 14.7 | 133.6 ± 15.2 |
| Diastolic BP, mm Hg | 75.0 ± 9.5 | 79.4 ± 9.9 | 77.2 ± 9.5 | 80.5 ± 9.8 |
| Fasting glucose, mg/dL | 92.8 ± 16.0 | 111.0 ± 30.9 | 93.1 ± 14.4 | 112.0 ± 29.6 |
| Total cholesterol, mg/dL | 196.6 ± 36.2 | 197.5 ± 40.4 | 201.6 ± 36.9 | 200.4 ± 40.6 |
| TG, mg/dL | 98.3 ± 42.5 | 163.2 ± 93.9 | 106.4 ± 43.7 | 175.2 ± 95.4 |
| HDL-C, mg/dL | 59.0 ± 17.7 | 50.3 ± 17.7 | 57.7 ± 17.3 | 49.2 ± 17.0 |
| LDL-C, mg/dL | 118.2 ± 33.4 | 115.4 ± 36.9 | 122.8 ± 34.3 | 117.1 ± 37.4 |
| Current smoker | 285,388 (16.4) | 293,240 (15.8) | 59,865 (9.3) | 150,405 (10.5) |
| Heavy drinker | 68,470 (3.9) | 92,641 (5.0) | 20,785 (3.2) | 61,843 (4.3) |
| Exercise | 759,858 (43.7) | 750,817 (40.5) | 284,349 (44.1) | 585,875 (40.9) |
| Low socioeconomic status | 384,236 (22.1) | 414,186 (22.4) | 139,787 (21.7) | 315,948 (22.0) |
| Comorbidities | ||||
| Hypertension | 484,857 (27.9) | 1,234,184 (66.6) | 262,942 (40.8) | 1,086,237 (75.7) |
| Diabetes | 75,192 (4.3) | 539,691 (29.1) | 26,257 (4.1) | 469,584 (32.7) |
| Hyperlipidemia | 149,566 (8.6) | 253,593 (13.7) | 67,287 (10.4) | 212,404 (14.8) |
| CKD | 162,082 (9.3) | 285,461 (15.4) | 72,966 (11.3) | 247,832 (17.3) |
| Previous myocardial infarction | 77,872 (4.5) | 127,374 (6.9) | 37,534 (5.8) | 116,146 (8.1) |
| Previous ischemic stroke | 80,878 (4.7) | 144,502 (7.8) | 33,838 (5.3) | 111,809 (7.8) |
| Characteristic . | Nonobese (n = 3,590,919) . | Obese (n = 2,078,569) . | ||
|---|---|---|---|---|
| MHNO (n = 1,738,074) . | MUNO (n = 1,852,845) . | MHO (n = 644,447) . | MUO (n = 1,434,122) . | |
| Age, y | 66.8 ± 6.4 | 68.1 ± 6.8 | 65.8 ± 5.6 | 66.9 ± 6.0 |
| Male sex | 867,637 (49.9) | 865,703 (46.7) | 263,261 (40.9) | 595,782 (41.5) |
| Height, cm | 158.9 ± 8.6 | 158.3 ± 8.8 | 157.7 ± 8.6 | 157.8 ± 8.8 |
| Weight, kg | 55.6 ± 7.9 | 56.8 ± 8.0 | 67.3 ± 8.1 | 68.4 ± 8.6 |
| BMI, kg/m2 | 22.0 ± 2.0 | 22.6 ± 1.8 | 27.0 ± 1.8 | 27.4 ± 2.1 |
| Systolic BP, mm Hg | 122.3 ± 14.8 | 132.0 ± 15.6 | 126.1 ± 14.7 | 133.6 ± 15.2 |
| Diastolic BP, mm Hg | 75.0 ± 9.5 | 79.4 ± 9.9 | 77.2 ± 9.5 | 80.5 ± 9.8 |
| Fasting glucose, mg/dL | 92.8 ± 16.0 | 111.0 ± 30.9 | 93.1 ± 14.4 | 112.0 ± 29.6 |
| Total cholesterol, mg/dL | 196.6 ± 36.2 | 197.5 ± 40.4 | 201.6 ± 36.9 | 200.4 ± 40.6 |
| TG, mg/dL | 98.3 ± 42.5 | 163.2 ± 93.9 | 106.4 ± 43.7 | 175.2 ± 95.4 |
| HDL-C, mg/dL | 59.0 ± 17.7 | 50.3 ± 17.7 | 57.7 ± 17.3 | 49.2 ± 17.0 |
| LDL-C, mg/dL | 118.2 ± 33.4 | 115.4 ± 36.9 | 122.8 ± 34.3 | 117.1 ± 37.4 |
| Current smoker | 285,388 (16.4) | 293,240 (15.8) | 59,865 (9.3) | 150,405 (10.5) |
| Heavy drinker | 68,470 (3.9) | 92,641 (5.0) | 20,785 (3.2) | 61,843 (4.3) |
| Exercise | 759,858 (43.7) | 750,817 (40.5) | 284,349 (44.1) | 585,875 (40.9) |
| Low socioeconomic status | 384,236 (22.1) | 414,186 (22.4) | 139,787 (21.7) | 315,948 (22.0) |
| Comorbidities | ||||
| Hypertension | 484,857 (27.9) | 1,234,184 (66.6) | 262,942 (40.8) | 1,086,237 (75.7) |
| Diabetes | 75,192 (4.3) | 539,691 (29.1) | 26,257 (4.1) | 469,584 (32.7) |
| Hyperlipidemia | 149,566 (8.6) | 253,593 (13.7) | 67,287 (10.4) | 212,404 (14.8) |
| CKD | 162,082 (9.3) | 285,461 (15.4) | 72,966 (11.3) | 247,832 (17.3) |
| Previous myocardial infarction | 77,872 (4.5) | 127,374 (6.9) | 37,534 (5.8) | 116,146 (8.1) |
| Previous ischemic stroke | 80,878 (4.7) | 144,502 (7.8) | 33,838 (5.3) | 111,809 (7.8) |
Values are presented as mean (SD) for continuous variables and n (%) for categorical variables.
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