Table 3. Open in new tab Metabolic...

		31 Years	46 Years
TC, mM	Cases	5.0 ± 1.0 (278)	0.426	0.103	5.4 ± 0.9 (364)	<0.001	<0.001
Controls	4.9 ± 0.9 (1580)	5.1 ± 0.8 (2275)
LDL-C, mM	Cases	2.8 ± 0.9 (278)	0.199	0.096	3.4 ± 0.9 (364)	0.001	<0.001
Controls	2.8 ± 0.8 (1576)	3.2 ± 0.8 (2275)
HDL-C, mM	Cases	1.7 ± 0.4 (278)	0.602	0.989	1.7 ± 0.4 (364)	0.003	0.022
Controls	1.7 ± 0.4 (1580)	1.6 ± 0.4 (2275)
Triglycerides, mM	Cases	1.0 ± 0.6 (278)	0.876	0.746	1.2 ± 0.7 (364)	0.028	0.008
Controls	1.0 ± 0.6 (1580)	1.0 ± 0.5 (2275)
T, nM	Cases	1.9 ± 0.7 (148)	0.040	0.018	1.4 ± 0.4 (361)	<0.001	0.001
Controls	2.1 ± 0.9 (873)	1.4 ± 0.4 (2271)
FAI	Cases	3.4 ± 2.2 (148)	0.164	0.009	1.7 ± 0.9 (362)	0.348	0.215
Controls	3.9 ± 3.1 (870)	1.8 ± 2.0 (2273)
hs-CRP, mg/L	Cases	2.2 ± 4.6 (269)	0.006	0.056	1.5 ± 1.8 (362)	0.016	0.078
Controls	2.3 ± 4.0 (1542)	1.6 ± 3.2 (2268)
ALT, IU/L	Cases				27.0 ± 21.2 (364)	<0.001	0.023
Controls		23.8 ± 18.4 (2275)
AST, IU/L	Cases				23.3 ± 16.7 (362)	<0.001	0.243
Controls		21.0 ± 27.9 (2274)
GGT, IU/L	Cases				31.5 ± 42.6 (363)	<0.001	<0.001
Controls		25.1 ± 29.6 (2274)

31 Years

46 Years

Variable

Means ± SD (n =)

P^a

P^b

Means ± SD (n =)

P^a

P^b

TC, mM

Cases

5.0 ± 1.0 (278)

0.426

0.103

5.4 ± 0.9 (364)

<0.001

Controls

4.9 ± 0.9 (1580)

5.1 ± 0.8 (2275)

LDL-C, mM

Cases

2.8 ± 0.9 (278)

0.199

0.096

3.4 ± 0.9 (364)

0.001

<0.001

Controls

2.8 ± 0.8 (1576)

3.2 ± 0.8 (2275)

HDL-C, mM

Cases

1.7 ± 0.4 (278)

0.602

0.989

1.7 ± 0.4 (364)

0.003

0.022

Controls

1.7 ± 0.4 (1580)

1.6 ± 0.4 (2275)

Triglycerides, mM

Cases

1.0 ± 0.6 (278)

0.876

0.746

1.2 ± 0.7 (364)

0.028

0.008

Controls

1.0 ± 0.6 (1580)

1.0 ± 0.5 (2275)

T, nM

Cases

1.9 ± 0.7 (148)

0.040

0.018

1.4 ± 0.4 (361)

<0.001

0.001

Controls

2.1 ± 0.9 (873)

1.4 ± 0.4 (2271)

FAI

Cases

3.4 ± 2.2 (148)

0.164

0.009

1.7 ± 0.9 (362)

0.348

0.215

Controls

3.9 ± 3.1 (870)

1.8 ± 2.0 (2273)

hs-CRP, mg/L

Cases

2.2 ± 4.6 (269)

0.006

0.056

1.5 ± 1.8 (362)

0.016

0.078

Controls

2.3 ± 4.0 (1542)

1.6 ± 3.2 (2268)

ALT, IU/L

Cases

27.0 ± 21.2 (364)

<0.001

0.023

Controls

23.8 ± 18.4 (2275)

AST, IU/L

Cases

23.3 ± 16.7 (362)

<0.001

0.243

Controls

21.0 ± 27.9 (2274)

GGT, IU/L

Cases

31.5 ± 42.6 (363)

<0.001

Controls

25.1 ± 29.6 (2274)

		31 Years	46 Years
TC, mM	Cases	5.0 ± 1.0 (278)	0.426	0.103	5.4 ± 0.9 (364)	<0.001	<0.001
Controls	4.9 ± 0.9 (1580)	5.1 ± 0.8 (2275)
LDL-C, mM	Cases	2.8 ± 0.9 (278)	0.199	0.096	3.4 ± 0.9 (364)	0.001	<0.001
Controls	2.8 ± 0.8 (1576)	3.2 ± 0.8 (2275)
HDL-C, mM	Cases	1.7 ± 0.4 (278)	0.602	0.989	1.7 ± 0.4 (364)	0.003	0.022
Controls	1.7 ± 0.4 (1580)	1.6 ± 0.4 (2275)
Triglycerides, mM	Cases	1.0 ± 0.6 (278)	0.876	0.746	1.2 ± 0.7 (364)	0.028	0.008
Controls	1.0 ± 0.6 (1580)	1.0 ± 0.5 (2275)
T, nM	Cases	1.9 ± 0.7 (148)	0.040	0.018	1.4 ± 0.4 (361)	<0.001	0.001
Controls	2.1 ± 0.9 (873)	1.4 ± 0.4 (2271)
FAI	Cases	3.4 ± 2.2 (148)	0.164	0.009	1.7 ± 0.9 (362)	0.348	0.215
Controls	3.9 ± 3.1 (870)	1.8 ± 2.0 (2273)
hs-CRP, mg/L	Cases	2.2 ± 4.6 (269)	0.006	0.056	1.5 ± 1.8 (362)	0.016	0.078
Controls	2.3 ± 4.0 (1542)	1.6 ± 3.2 (2268)
ALT, IU/L	Cases				27.0 ± 21.2 (364)	<0.001	0.023
Controls		23.8 ± 18.4 (2275)
AST, IU/L	Cases				23.3 ± 16.7 (362)	<0.001	0.243
Controls		21.0 ± 27.9 (2274)
GGT, IU/L	Cases				31.5 ± 42.6 (363)	<0.001	<0.001
Controls		25.1 ± 29.6 (2274)

Table 3.

Open in new tab

Metabolic Outcomes in Climacteric Women (Cases) and Preclimacteric Women (Controls) at the Ages of 31 and 46

		31 Years			46 Years
Variable		Means ± SD (n =)	P^a	P^b	Means ± SD (n =)	P^a	P^b
TC, mM	Cases	5.0 ± 1.0 (278)	0.426	0.103	5.4 ± 0.9 (364)	<0.001	<0.001
TC, mM	Controls	4.9 ± 0.9 (1580)	0.426	0.103	5.1 ± 0.8 (2275)	<0.001	<0.001
LDL-C, mM	Cases	2.8 ± 0.9 (278)	0.199	0.096	3.4 ± 0.9 (364)	0.001	<0.001
LDL-C, mM	Controls	2.8 ± 0.8 (1576)	0.199	0.096	3.2 ± 0.8 (2275)	0.001	<0.001
HDL-C, mM	Cases	1.7 ± 0.4 (278)	0.602	0.989	1.7 ± 0.4 (364)	0.003	0.022
HDL-C, mM	Controls	1.7 ± 0.4 (1580)	0.602	0.989	1.6 ± 0.4 (2275)	0.003	0.022
Triglycerides, mM	Cases	1.0 ± 0.6 (278)	0.876	0.746	1.2 ± 0.7 (364)	0.028	0.008
Triglycerides, mM	Controls	1.0 ± 0.6 (1580)	0.876	0.746	1.0 ± 0.5 (2275)	0.028	0.008
T, nM	Cases	1.9 ± 0.7 (148)	0.040	0.018	1.4 ± 0.4 (361)	<0.001	0.001
T, nM	Controls	2.1 ± 0.9 (873)	0.040	0.018	1.4 ± 0.4 (2271)	<0.001	0.001
FAI	Cases	3.4 ± 2.2 (148)	0.164	0.009	1.7 ± 0.9 (362)	0.348	0.215
FAI	Controls	3.9 ± 3.1 (870)	0.164	0.009	1.8 ± 2.0 (2273)	0.348	0.215
hs-CRP, mg/L	Cases	2.2 ± 4.6 (269)	0.006	0.056	1.5 ± 1.8 (362)	0.016	0.078
hs-CRP, mg/L	Controls	2.3 ± 4.0 (1542)	0.006	0.056	1.6 ± 3.2 (2268)	0.016	0.078
ALT, IU/L	Cases				27.0 ± 21.2 (364)	<0.001	0.023
ALT, IU/L	Controls				23.8 ± 18.4 (2275)	<0.001	0.023
AST, IU/L	Cases				23.3 ± 16.7 (362)	<0.001	0.243
AST, IU/L	Controls				21.0 ± 27.9 (2274)	<0.001	0.243
GGT, IU/L	Cases				31.5 ± 42.6 (363)	<0.001	<0.001
GGT, IU/L	Controls				25.1 ± 29.6 (2274)	<0.001	<0.001

		31 Years			46 Years
Variable		Means ± SD (n =)	P^a	P^b	Means ± SD (n =)	P^a	P^b
TC, mM	Cases	5.0 ± 1.0 (278)	0.426	0.103	5.4 ± 0.9 (364)	<0.001	<0.001
TC, mM	Controls	4.9 ± 0.9 (1580)	0.426	0.103	5.1 ± 0.8 (2275)	<0.001	<0.001
LDL-C, mM	Cases	2.8 ± 0.9 (278)	0.199	0.096	3.4 ± 0.9 (364)	0.001	<0.001
LDL-C, mM	Controls	2.8 ± 0.8 (1576)	0.199	0.096	3.2 ± 0.8 (2275)	0.001	<0.001
HDL-C, mM	Cases	1.7 ± 0.4 (278)	0.602	0.989	1.7 ± 0.4 (364)	0.003	0.022
HDL-C, mM	Controls	1.7 ± 0.4 (1580)	0.602	0.989	1.6 ± 0.4 (2275)	0.003	0.022
Triglycerides, mM	Cases	1.0 ± 0.6 (278)	0.876	0.746	1.2 ± 0.7 (364)	0.028	0.008
Triglycerides, mM	Controls	1.0 ± 0.6 (1580)	0.876	0.746	1.0 ± 0.5 (2275)	0.028	0.008
T, nM	Cases	1.9 ± 0.7 (148)	0.040	0.018	1.4 ± 0.4 (361)	<0.001	0.001
T, nM	Controls	2.1 ± 0.9 (873)	0.040	0.018	1.4 ± 0.4 (2271)	<0.001	0.001
FAI	Cases	3.4 ± 2.2 (148)	0.164	0.009	1.7 ± 0.9 (362)	0.348	0.215
FAI	Controls	3.9 ± 3.1 (870)	0.164	0.009	1.8 ± 2.0 (2273)	0.348	0.215
hs-CRP, mg/L	Cases	2.2 ± 4.6 (269)	0.006	0.056	1.5 ± 1.8 (362)	0.016	0.078
hs-CRP, mg/L	Controls	2.3 ± 4.0 (1542)	0.006	0.056	1.6 ± 3.2 (2268)	0.016	0.078
ALT, IU/L	Cases				27.0 ± 21.2 (364)	<0.001	0.023
ALT, IU/L	Controls				23.8 ± 18.4 (2275)	<0.001	0.023
AST, IU/L	Cases				23.3 ± 16.7 (362)	<0.001	0.243
AST, IU/L	Controls				21.0 ± 27.9 (2274)	<0.001	0.243
GGT, IU/L	Cases				31.5 ± 42.6 (363)	<0.001	<0.001
GGT, IU/L	Controls				25.1 ± 29.6 (2274)	<0.001	<0.001

The analyses were adjusted for age at menarche, parity, smoking, level of education, and physical activity. The study subjects were participants in the NFBC1966. Climacteric status was determined at the age of 46 by menstrual anamnesis and FSH value.

P, crude P value.

P, adjusted P value.

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