Table 2.
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Parameter estimates for ciprofloxacin from the final covariate two-compartment population PK model

ParametersMeanSDCoefficient of variationMedian
CLCIP (L/h)15.2416.53842.89714.480
Vc (L)38.56421.28255.18637.971
kcp (h−1)2.4612.816114.3971.653
kpc (h−1)1.3044.299329.6560.671
ParametersMeanSDCoefficient of variationMedian
CLCIP (L/h)15.2416.53842.89714.480
Vc (L)38.56421.28255.18637.971
kcp (h−1)2.4612.816114.3971.653
kpc (h−1)1.3044.299329.6560.671

CLCIP, total ciprofloxacin CL; Vc, central V; kcp, rate constant for drug distribution from the central to peripheral compartment; kpc, rate constant for drug distribution from the peripheral to central compartment.

Table 2.
Open in new tab

Parameter estimates for ciprofloxacin from the final covariate two-compartment population PK model

ParametersMeanSDCoefficient of variationMedian
CLCIP (L/h)15.2416.53842.89714.480
Vc (L)38.56421.28255.18637.971
kcp (h−1)2.4612.816114.3971.653
kpc (h−1)1.3044.299329.6560.671
ParametersMeanSDCoefficient of variationMedian
CLCIP (L/h)15.2416.53842.89714.480
Vc (L)38.56421.28255.18637.971
kcp (h−1)2.4612.816114.3971.653
kpc (h−1)1.3044.299329.6560.671

CLCIP, total ciprofloxacin CL; Vc, central V; kcp, rate constant for drug distribution from the central to peripheral compartment; kpc, rate constant for drug distribution from the peripheral to central compartment.

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