Table 2. Open in new tab Association...

Variable	T1D	T2D	P Value^a
Age^b	−0.4 (−1.3 to 0.5)	0.378	0.3 (−0.6 to 1.2)	0.495	0.269
Female sex^c	−5.7 (−21.4 to 13.2)	0.533	−7.2 (−22.4 to 10.9)	0.413	0.898
Weight	−0.3 (−1.8 to 1.1)	0.646	0.3 (−0.9 to 1.6)	0.589	0.462
BMI^b	−5.6 (−7.6 to −3.6)	< 0.001^d	−4.6 (−6.6 to −2.6)	< 0.001^d	0.470
Waist circumference	−1.1 (−2.7 to 0.4)	0.159	−0.9 (−2.4 to 0.7)	0.280	0.870
WHR^b	−67.4 (−93.1 to 55.3)	0.164	−79.0 (−96.6 to 32.3)	0.102	0.674
Diabetes duration^b	−0.1 (−0.1 to 0.0)	0.304	0.0 (0.0 to 0.1)	0.269	0.131
Fasting glucose^b	−4.8 (−7.8 to −1.6)	0.005^d	−7.0 (−12.0 to −0.17)	0.013^d	0.507
HbA1c, mmol/mol^b	−0.57 (−1.11 to −0.02)	0.047^d	−0.75 (−1.66 to 0.16)	0.113	0.746
HbA1c, %^b	−6.0 (−11.5 to −0.2)	0.047^d	−7.9 (−16.5 to 1.8)	0.113	0.746
Triglycerides^e^,^f	−2.2 (−3.8 to −0.5)	0.012^d	−1.7 (−2.9 to −0.4)	0.011^d	0.633
HDL^b^,^f	16.7 (−7.4 to 47.2)	0.196	31.0 (−1.8 to 74.7)	0.071	0.475
LDL^b^,^f	4.7 (−5.4 to 15.9)	0.377	−3.9 (−12.0 to 5.0)	0.382	0.216
AST^e	1.8 (−0.9 to 4.6)	0.196	−0.3 (−2.4 to 1.8)	0.765	0.224
ALT^e	0.4 (−1.6 to 2.4)	0.703	−1.0 (−2.4 to 0.4)	0.161	0.275
GGT^e	0.01 (−1.5 to 1.5)	0.989	−1.5 (−2.8 to −0.1)	0.047^d	0.176
CRP^e	−0.7 (−1.5 to 0.1)	0.078	−0.7 (−1.6 to 0.1)	0.105	0.982
IL-6^e	−0.1 (−1.3 to 1.1)	0.881	−0.5 (−1.6 to 0.6)	0.368	0.673
Total adiponectin^e	0.5 (−2.1 to 3.2)	0.881	2.9 (0.6 to 5.1)	0.015^d	0.171
HMW adiponectin^e	0.6 (−1.0 to 2.3)	0.472	1.8 (0.1 to 3.4)	0.039^d	0.240
HMW/total adiponectin ratio^e	1.7 (−1.6 to 5.1)	0.318	1.7 (−2.5 to 6.0)	0.447	0.771

Variable

T1D

T2D

P Value^a

Change in M-Value, % (95% CI)

P Value

Change in M-Value, % (95% CI)

P Value

Age^b

−0.4 (−1.3 to 0.5)

0.378

0.3 (−0.6 to 1.2)

0.495

0.269

Female sex^c

−5.7 (−21.4 to 13.2)

0.533

−7.2 (−22.4 to 10.9)

0.413

0.898

Weight

−0.3 (−1.8 to 1.1)

0.646

0.3 (−0.9 to 1.6)

0.589

0.462

BMI^b

−5.6 (−7.6 to −3.6)

< 0.001^d

−4.6 (−6.6 to −2.6)

< 0.001^d

0.470

Waist circumference

−1.1 (−2.7 to 0.4)

0.159

−0.9 (−2.4 to 0.7)

0.280

0.870

WHR^b

−67.4 (−93.1 to 55.3)

0.164

−79.0 (−96.6 to 32.3)

0.102

0.674

Diabetes duration^b

−0.1 (−0.1 to 0.0)

0.304

0.0 (0.0 to 0.1)

0.269

0.131

Fasting glucose^b

−4.8 (−7.8 to −1.6)

0.005^d

−7.0 (−12.0 to −0.17)

0.013^d

0.507

HbA1c, mmol/mol^b

−0.57 (−1.11 to −0.02)

0.047^d

−0.75 (−1.66 to 0.16)

0.113

0.746

HbA1c, %^b

−6.0 (−11.5 to −0.2)

0.047^d

−7.9 (−16.5 to 1.8)

0.113

0.746

Triglycerides^e^,^f

−2.2 (−3.8 to −0.5)

0.012^d

−1.7 (−2.9 to −0.4)

0.011^d

0.633

HDL^b^,^f

16.7 (−7.4 to 47.2)

0.196

31.0 (−1.8 to 74.7)

0.071

0.475

LDL^b^,^f

4.7 (−5.4 to 15.9)

0.377

−3.9 (−12.0 to 5.0)

0.382

0.216

AST^e

1.8 (−0.9 to 4.6)

0.196

−0.3 (−2.4 to 1.8)

0.765

0.224

ALT^e

0.4 (−1.6 to 2.4)

0.703

−1.0 (−2.4 to 0.4)

0.161

0.275

GGT^e

0.01 (−1.5 to 1.5)

0.989

−1.5 (−2.8 to −0.1)

0.047^d

0.176

CRP^e

−0.7 (−1.5 to 0.1)

0.078

−0.7 (−1.6 to 0.1)

0.105

0.982

IL-6^e

−0.1 (−1.3 to 1.1)

0.881

−0.5 (−1.6 to 0.6)

0.368

0.673

Total adiponectin^e

0.5 (−2.1 to 3.2)

0.881

2.9 (0.6 to 5.1)

0.015^d

0.171

HMW adiponectin^e

0.6 (−1.0 to 2.3)

0.472

1.8 (0.1 to 3.4)

0.039^d

0.240

HMW/total adiponectin ratio^e

1.7 (−1.6 to 5.1)

0.318

1.7 (−2.5 to 6.0)

0.447

0.771

Variable	T1D	T2D	P Value^a
Age^b	−0.4 (−1.3 to 0.5)	0.378	0.3 (−0.6 to 1.2)	0.495	0.269
Female sex^c	−5.7 (−21.4 to 13.2)	0.533	−7.2 (−22.4 to 10.9)	0.413	0.898
Weight	−0.3 (−1.8 to 1.1)	0.646	0.3 (−0.9 to 1.6)	0.589	0.462
BMI^b	−5.6 (−7.6 to −3.6)	< 0.001^d	−4.6 (−6.6 to −2.6)	< 0.001^d	0.470
Waist circumference	−1.1 (−2.7 to 0.4)	0.159	−0.9 (−2.4 to 0.7)	0.280	0.870
WHR^b	−67.4 (−93.1 to 55.3)	0.164	−79.0 (−96.6 to 32.3)	0.102	0.674
Diabetes duration^b	−0.1 (−0.1 to 0.0)	0.304	0.0 (0.0 to 0.1)	0.269	0.131
Fasting glucose^b	−4.8 (−7.8 to −1.6)	0.005^d	−7.0 (−12.0 to −0.17)	0.013^d	0.507
HbA1c, mmol/mol^b	−0.57 (−1.11 to −0.02)	0.047^d	−0.75 (−1.66 to 0.16)	0.113	0.746
HbA1c, %^b	−6.0 (−11.5 to −0.2)	0.047^d	−7.9 (−16.5 to 1.8)	0.113	0.746
Triglycerides^e^,^f	−2.2 (−3.8 to −0.5)	0.012^d	−1.7 (−2.9 to −0.4)	0.011^d	0.633
HDL^b^,^f	16.7 (−7.4 to 47.2)	0.196	31.0 (−1.8 to 74.7)	0.071	0.475
LDL^b^,^f	4.7 (−5.4 to 15.9)	0.377	−3.9 (−12.0 to 5.0)	0.382	0.216
AST^e	1.8 (−0.9 to 4.6)	0.196	−0.3 (−2.4 to 1.8)	0.765	0.224
ALT^e	0.4 (−1.6 to 2.4)	0.703	−1.0 (−2.4 to 0.4)	0.161	0.275
GGT^e	0.01 (−1.5 to 1.5)	0.989	−1.5 (−2.8 to −0.1)	0.047^d	0.176
CRP^e	−0.7 (−1.5 to 0.1)	0.078	−0.7 (−1.6 to 0.1)	0.105	0.982
IL-6^e	−0.1 (−1.3 to 1.1)	0.881	−0.5 (−1.6 to 0.6)	0.368	0.673
Total adiponectin^e	0.5 (−2.1 to 3.2)	0.881	2.9 (0.6 to 5.1)	0.015^d	0.171
HMW adiponectin^e	0.6 (−1.0 to 2.3)	0.472	1.8 (0.1 to 3.4)	0.039^d	0.240
HMW/total adiponectin ratio^e	1.7 (−1.6 to 5.1)	0.318	1.7 (−2.5 to 6.0)	0.447	0.771

Table 2.

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Association Between Risk Factors and M-Value

Variable	T1D		T2D		P Value^a
Variable	Change in M-Value, % (95% CI)	P Value	Change in M-Value, % (95% CI)	P Value	P Value^a
Age^b	−0.4 (−1.3 to 0.5)	0.378	0.3 (−0.6 to 1.2)	0.495	0.269
Female sex^c	−5.7 (−21.4 to 13.2)	0.533	−7.2 (−22.4 to 10.9)	0.413	0.898
Weight	−0.3 (−1.8 to 1.1)	0.646	0.3 (−0.9 to 1.6)	0.589	0.462
BMI^b	−5.6 (−7.6 to −3.6)	< 0.001^d	−4.6 (−6.6 to −2.6)	< 0.001^d	0.470
Waist circumference	−1.1 (−2.7 to 0.4)	0.159	−0.9 (−2.4 to 0.7)	0.280	0.870
WHR^b	−67.4 (−93.1 to 55.3)	0.164	−79.0 (−96.6 to 32.3)	0.102	0.674
Diabetes duration^b	−0.1 (−0.1 to 0.0)	0.304	0.0 (0.0 to 0.1)	0.269	0.131
Fasting glucose^b	−4.8 (−7.8 to −1.6)	0.005^d	−7.0 (−12.0 to −0.17)	0.013^d	0.507
HbA1c, mmol/mol^b	−0.57 (−1.11 to −0.02)	0.047^d	−0.75 (−1.66 to 0.16)	0.113	0.746
HbA1c, %^b	−6.0 (−11.5 to −0.2)	0.047^d	−7.9 (−16.5 to 1.8)	0.113	0.746
Triglycerides^e^,^f	−2.2 (−3.8 to −0.5)	0.012^d	−1.7 (−2.9 to −0.4)	0.011^d	0.633
HDL^b^,^f	16.7 (−7.4 to 47.2)	0.196	31.0 (−1.8 to 74.7)	0.071	0.475
LDL^b^,^f	4.7 (−5.4 to 15.9)	0.377	−3.9 (−12.0 to 5.0)	0.382	0.216
AST^e	1.8 (−0.9 to 4.6)	0.196	−0.3 (−2.4 to 1.8)	0.765	0.224
ALT^e	0.4 (−1.6 to 2.4)	0.703	−1.0 (−2.4 to 0.4)	0.161	0.275
GGT^e	0.01 (−1.5 to 1.5)	0.989	−1.5 (−2.8 to −0.1)	0.047^d	0.176
CRP^e	−0.7 (−1.5 to 0.1)	0.078	−0.7 (−1.6 to 0.1)	0.105	0.982
IL-6^e	−0.1 (−1.3 to 1.1)	0.881	−0.5 (−1.6 to 0.6)	0.368	0.673
Total adiponectin^e	0.5 (−2.1 to 3.2)	0.881	2.9 (0.6 to 5.1)	0.015^d	0.171
HMW adiponectin^e	0.6 (−1.0 to 2.3)	0.472	1.8 (0.1 to 3.4)	0.039^d	0.240
HMW/total adiponectin ratio^e	1.7 (−1.6 to 5.1)	0.318	1.7 (−2.5 to 6.0)	0.447	0.771

Variable	T1D		T2D		P Value^a
Variable	Change in M-Value, % (95% CI)	P Value	Change in M-Value, % (95% CI)	P Value	P Value^a
Age^b	−0.4 (−1.3 to 0.5)	0.378	0.3 (−0.6 to 1.2)	0.495	0.269
Female sex^c	−5.7 (−21.4 to 13.2)	0.533	−7.2 (−22.4 to 10.9)	0.413	0.898
Weight	−0.3 (−1.8 to 1.1)	0.646	0.3 (−0.9 to 1.6)	0.589	0.462
BMI^b	−5.6 (−7.6 to −3.6)	< 0.001^d	−4.6 (−6.6 to −2.6)	< 0.001^d	0.470
Waist circumference	−1.1 (−2.7 to 0.4)	0.159	−0.9 (−2.4 to 0.7)	0.280	0.870
WHR^b	−67.4 (−93.1 to 55.3)	0.164	−79.0 (−96.6 to 32.3)	0.102	0.674
Diabetes duration^b	−0.1 (−0.1 to 0.0)	0.304	0.0 (0.0 to 0.1)	0.269	0.131
Fasting glucose^b	−4.8 (−7.8 to −1.6)	0.005^d	−7.0 (−12.0 to −0.17)	0.013^d	0.507
HbA1c, mmol/mol^b	−0.57 (−1.11 to −0.02)	0.047^d	−0.75 (−1.66 to 0.16)	0.113	0.746
HbA1c, %^b	−6.0 (−11.5 to −0.2)	0.047^d	−7.9 (−16.5 to 1.8)	0.113	0.746
Triglycerides^e^,^f	−2.2 (−3.8 to −0.5)	0.012^d	−1.7 (−2.9 to −0.4)	0.011^d	0.633
HDL^b^,^f	16.7 (−7.4 to 47.2)	0.196	31.0 (−1.8 to 74.7)	0.071	0.475
LDL^b^,^f	4.7 (−5.4 to 15.9)	0.377	−3.9 (−12.0 to 5.0)	0.382	0.216
AST^e	1.8 (−0.9 to 4.6)	0.196	−0.3 (−2.4 to 1.8)	0.765	0.224
ALT^e	0.4 (−1.6 to 2.4)	0.703	−1.0 (−2.4 to 0.4)	0.161	0.275
GGT^e	0.01 (−1.5 to 1.5)	0.989	−1.5 (−2.8 to −0.1)	0.047^d	0.176
CRP^e	−0.7 (−1.5 to 0.1)	0.078	−0.7 (−1.6 to 0.1)	0.105	0.982
IL-6^e	−0.1 (−1.3 to 1.1)	0.881	−0.5 (−1.6 to 0.6)	0.368	0.673
Total adiponectin^e	0.5 (−2.1 to 3.2)	0.881	2.9 (0.6 to 5.1)	0.015^d	0.171
HMW adiponectin^e	0.6 (−1.0 to 2.3)	0.472	1.8 (0.1 to 3.4)	0.039^d	0.240
HMW/total adiponectin ratio^e	1.7 (−1.6 to 5.1)	0.318	1.7 (−2.5 to 6.0)	0.447	0.771

Multiple linear regression models adjusted for age, sex, and BMI.

P value for difference of relative change in M-value between T1D and T2D.

Relative change in M-value (%) for a one-unit increase of an independent variable.  ^cRelative change in M-value (%) compared with men.

Statistically significant.

Relative change in M-value (%) for a 10%-change in the independent variable.

Also adjusted for lipid-lowering agents.

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