Improvement and Protection in Best-Ear and Total-Ear Hearing Between Baseline and Follow-Up in Subjects With Complete Viral Suppression by Day 14 of Therapy Through Month 6, and Subjects Without Complete Viral Suppressiona
| Analysis | No. of Subjects or Ears | Hearing Between Baseline and Follow-up | P Value | |
| Improved/Protected | Others | |||
| 6-Month Best-Ear | ||||
| With complete suppression | 9 | 8 (89) | 1 (11) | .23 |
| Without complete suppression | 26 | 17 (65) | 9 (35) | |
| 6-Month Total-Ear | ||||
| With complete suppression | 17 | 15 (88) | 2 (12) | .0366 |
| Without complete suppression | 50 | 29 (58) | 21 (42) | |
| 12-Month Best-Ear | ||||
| With complete suppression | 9 | 9 (100) | 0 | .08 |
| Without complete suppression | 26 | 18 (69) | 8 (31) | |
| 12-Month Total-Ear | ||||
| With complete suppression | 18 | 18 (100) | 0 | .0017 |
| Without complete suppression | 50 | 32 (64) | 18 (36) | |
| 24-Month Best-Ear | ||||
| With complete suppression | 8 | 8 (100) | 0 | .29 |
| Without complete suppression | 23 | 18 (78) | 5 (22) | |
| 24-Month Total-Ear | ||||
| With complete suppression | 15 | 14 (93) | 1 (7) | .08 |
| Without complete suppression | 43 | 30 (70) | 13 (30) |
| Analysis | No. of Subjects or Ears | Hearing Between Baseline and Follow-up | P Value | |
| Improved/Protected | Others | |||
| 6-Month Best-Ear | ||||
| With complete suppression | 9 | 8 (89) | 1 (11) | .23 |
| Without complete suppression | 26 | 17 (65) | 9 (35) | |
| 6-Month Total-Ear | ||||
| With complete suppression | 17 | 15 (88) | 2 (12) | .0366 |
| Without complete suppression | 50 | 29 (58) | 21 (42) | |
| 12-Month Best-Ear | ||||
| With complete suppression | 9 | 9 (100) | 0 | .08 |
| Without complete suppression | 26 | 18 (69) | 8 (31) | |
| 12-Month Total-Ear | ||||
| With complete suppression | 18 | 18 (100) | 0 | .0017 |
| Without complete suppression | 50 | 32 (64) | 18 (36) | |
| 24-Month Best-Ear | ||||
| With complete suppression | 8 | 8 (100) | 0 | .29 |
| Without complete suppression | 23 | 18 (78) | 5 (22) | |
| 24-Month Total-Ear | ||||
| With complete suppression | 15 | 14 (93) | 1 (7) | .08 |
| Without complete suppression | 43 | 30 (70) | 13 (30) |
aHearing outcomes between the 2 groups were compared using Fisher’s exact test. Data are no. (%) of subjects in the best-ear assessment and no. (%) of ears in the total-ear assessment.
Improvement and Protection in Best-Ear and Total-Ear Hearing Between Baseline and Follow-Up in Subjects With Complete Viral Suppression by Day 14 of Therapy Through Month 6, and Subjects Without Complete Viral Suppressiona
| Analysis | No. of Subjects or Ears | Hearing Between Baseline and Follow-up | P Value | |
| Improved/Protected | Others | |||
| 6-Month Best-Ear | ||||
| With complete suppression | 9 | 8 (89) | 1 (11) | .23 |
| Without complete suppression | 26 | 17 (65) | 9 (35) | |
| 6-Month Total-Ear | ||||
| With complete suppression | 17 | 15 (88) | 2 (12) | .0366 |
| Without complete suppression | 50 | 29 (58) | 21 (42) | |
| 12-Month Best-Ear | ||||
| With complete suppression | 9 | 9 (100) | 0 | .08 |
| Without complete suppression | 26 | 18 (69) | 8 (31) | |
| 12-Month Total-Ear | ||||
| With complete suppression | 18 | 18 (100) | 0 | .0017 |
| Without complete suppression | 50 | 32 (64) | 18 (36) | |
| 24-Month Best-Ear | ||||
| With complete suppression | 8 | 8 (100) | 0 | .29 |
| Without complete suppression | 23 | 18 (78) | 5 (22) | |
| 24-Month Total-Ear | ||||
| With complete suppression | 15 | 14 (93) | 1 (7) | .08 |
| Without complete suppression | 43 | 30 (70) | 13 (30) |
| Analysis | No. of Subjects or Ears | Hearing Between Baseline and Follow-up | P Value | |
| Improved/Protected | Others | |||
| 6-Month Best-Ear | ||||
| With complete suppression | 9 | 8 (89) | 1 (11) | .23 |
| Without complete suppression | 26 | 17 (65) | 9 (35) | |
| 6-Month Total-Ear | ||||
| With complete suppression | 17 | 15 (88) | 2 (12) | .0366 |
| Without complete suppression | 50 | 29 (58) | 21 (42) | |
| 12-Month Best-Ear | ||||
| With complete suppression | 9 | 9 (100) | 0 | .08 |
| Without complete suppression | 26 | 18 (69) | 8 (31) | |
| 12-Month Total-Ear | ||||
| With complete suppression | 18 | 18 (100) | 0 | .0017 |
| Without complete suppression | 50 | 32 (64) | 18 (36) | |
| 24-Month Best-Ear | ||||
| With complete suppression | 8 | 8 (100) | 0 | .29 |
| Without complete suppression | 23 | 18 (78) | 5 (22) | |
| 24-Month Total-Ear | ||||
| With complete suppression | 15 | 14 (93) | 1 (7) | .08 |
| Without complete suppression | 43 | 30 (70) | 13 (30) |
aHearing outcomes between the 2 groups were compared using Fisher’s exact test. Data are no. (%) of subjects in the best-ear assessment and no. (%) of ears in the total-ear assessment.
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