Table 1. Open in new tab Parameter...

Parameter

Unit

Abbreviation

Range

Format

Distribution

Justification

Initial parasite number

P₀

10^x, where

(x \in ℝ | 10 < x < 12)

Double

Uniform

[25, 27]

Mean of initial age-bin distribution

[h]

Mean

x + 0.5, where

(x \in ℕ | 0 \leq x \leq 47)

Integer

Triangular with mode = 10

[25, 26], Supplementary Information

Standard deviation of initial age-bin distribution

[h]

x, where

(x \in ℕ | 2 \leq x \leq 4)

Integer

Uniform

[27], Supplementary Information

Parasite multiplication rate

PMR

x, where

(x \in ℕ | 1 \leq x \leq 10)

Integer

Triangular with mode = 1

[26, 27]

Pathological recovery rate half-life

[h⁻¹]

r = ln(2)/x

x, where

(x \in ℕ | 4 \leq x \leq 12)

Integer

Uniform

Splenic clearance rate half-life

[h⁻¹]

u = ln(2)/x

x, where mean = 2.7 and CV = 0.3

Double

Normal

[28, 29]

Half-maximum inhibitory concentrations AS

[mg/L]

IC50_AS

x, where mean = 0.0016 and CV = 0.86

Double

Log-normal

[20]

Half-maximum inhibitory concentrations DHA

[mg/L]

IC50_DHA

x, where mean = 0.009 and CV = 1.17

Double

Log-normal

[20]

Maximal rate of drug killing

[h⁻¹]

V_max

x, where mean = 1.78 and CV = 0.1

Double

Normal

[20, 22]

Slope factor

x, where mean = 4 and CV = 0.3

Double

Normal

[20]

Table 1.

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Parameter Values Used in the Simulations^a

Parameter	Unit	Abbreviation	Range	Format	Distribution	Justification
Initial parasite number		P₀	10^x, where $(x \in ℝ \| 10 < x < 12)$	Double	Uniform	[25, 27]
Mean of initial age-bin distribution	[h]	Mean	x + 0.5, where $(x \in ℕ \| 0 \leq x \leq 47)$	Integer	Triangular with mode = 10	[25, 26], Supplementary Information
Standard deviation of initial age-bin distribution	[h]	SD	x, where $(x \in ℕ \| 2 \leq x \leq 4)$	Integer	Uniform	[27], Supplementary Information
Parasite multiplication rate		PMR	x, where $(x \in ℕ \| 1 \leq x \leq 10)$	Integer	Triangular with mode = 1	[26, 27]
Pathological recovery rate half-life	[h⁻¹]	r = ln(2)/x	x, where $(x \in ℕ \| 4 \leq x \leq 12)$	Integer	Uniform
Splenic clearance rate half-life	[h⁻¹]	u = ln(2)/x	x, where mean = 2.7 and CV = 0.3	Double	Normal	[28, 29]
Half-maximum inhibitory concentrations AS	[mg/L]	IC50_AS	x, where mean = 0.0016 and CV = 0.86	Double	Log-normal	[20]
Half-maximum inhibitory concentrations DHA	[mg/L]	IC50_DHA	x, where mean = 0.009 and CV = 1.17	Double	Log-normal	[20]
Maximal rate of drug killing	[h⁻¹]	V_max	x, where mean = 1.78 and CV = 0.1	Double	Normal	[20, 22]
Slope factor		n	x, where mean = 4 and CV = 0.3	Double	Normal	[20]

Parameter	Unit	Abbreviation	Range	Format	Distribution	Justification
Initial parasite number		P₀	10^x, where $(x \in ℝ \| 10 < x < 12)$	Double	Uniform	[25, 27]
Mean of initial age-bin distribution	[h]	Mean	x + 0.5, where $(x \in ℕ \| 0 \leq x \leq 47)$	Integer	Triangular with mode = 10	[25, 26], Supplementary Information
Standard deviation of initial age-bin distribution	[h]	SD	x, where $(x \in ℕ \| 2 \leq x \leq 4)$	Integer	Uniform	[27], Supplementary Information
Parasite multiplication rate		PMR	x, where $(x \in ℕ \| 1 \leq x \leq 10)$	Integer	Triangular with mode = 1	[26, 27]
Pathological recovery rate half-life	[h⁻¹]	r = ln(2)/x	x, where $(x \in ℕ \| 4 \leq x \leq 12)$	Integer	Uniform
Splenic clearance rate half-life	[h⁻¹]	u = ln(2)/x	x, where mean = 2.7 and CV = 0.3	Double	Normal	[28, 29]
Half-maximum inhibitory concentrations AS	[mg/L]	IC50_AS	x, where mean = 0.0016 and CV = 0.86	Double	Log-normal	[20]
Half-maximum inhibitory concentrations DHA	[mg/L]	IC50_DHA	x, where mean = 0.009 and CV = 1.17	Double	Log-normal	[20]
Maximal rate of drug killing	[h⁻¹]	V_max	x, where mean = 1.78 and CV = 0.1	Double	Normal	[20, 22]
Slope factor		n	x, where mean = 4 and CV = 0.3	Double	Normal	[20]

Abbreviations: AS, artesunate; CV, coefficient of variation; DHA, dihydroartemisinin.

^aNot including volume of distribution (V_d) / clearance (Cl). See Supplementary information for discussion of those parameters.

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