Voxel-wise multiple regression analyses showed that global cognition was positively associated with FDG-PET uptake in the bilateral anterior-mid cingulate gyrus (dorsal and ventral sections of the anterior cingulate) extending to the medial prefrontal cortex (rostral and medial sections), and the bilateral anterior temporal lobes (Fig. 2). Peak coordinates are provided in Supplementary Table 2. The most significant peaks were located in the left temporal pole and left anterior cingulate gyrus. The peak coordinates and cluster size of the significant results are provided in Table 3. Of note, the cognitively stable 80+ group did not show any association between global cognition and the Alzheimer’s disease signature regions which supports the multiple regression analyses presented in the previous section.