Table 3. Open in new tab Median Age at...

Predicted Median Age at Onset  (95% CI)

Predicted Risk from Age 40 to 50  (95% CI)

Predicted Risk Ratio from Age 40 to 50  (95% CI)

Predicted Risk Difference (in Percentage Points) from Age 40 to 50  (95% CI)

Not PCOSp

PCOSp

Not PCOSp

PCOSp

Not PCOSp

PCOSp

Not PCOSp

PCOSp

For all women, regardless of covariates:

Model 1^a

54.5 (52.5, 56.7)

47.4 (43.0, 52.3)

0.27 (0.23, 0.31)

0.37 (0.29, 0.46)

ref

1.38 (1.08, 1.69)

ref

10.3 (2.3, 18.3)

For women with a mean covariate profile^c:

Model 3^b

51.5 (49.5, 53.5)

48.7 (45.1, 52.6)

0.37 (0.30, 0.43)

0.44 (0.33, 0.56)

ref

1.21 (0.91, 1.51)

ref

7.7 (−3.1, 18.4)

For women with specified combinations of BMI and smoking status, adjusted for education and physical activity^d:

\bar{BMI}

_38–54

Smoking

Model 3

Normal

Never

65.1 (61.7, 68.9)

61.5 (56.4, 67.2)

0.10 (0.07, 0.14)

0.15 (0.07, 0.23)

ref

1.46 (0.70, 2.22)

ref

4.8 (−2.4, 12)

Normal

Current

63.5 (59.1, 68.2)

60.1 (54.1, 66.7)

0.12 (0.07, 0.18)

0.18 (0.07, 0.28)

ref

1.43 (0.74, 2.12)

ref

5.3 (−2.8, 13.3)

Obese

Never

45.7 (43.9, 47.6)

43.3 (40.1, 46.7)

0.53 (0.45, 0.6)

0.60 (0.48, 0.72)

ref

1.13 (0.95, 1.32)

ref

7.1 (−2.6, 16.7)

Obese

Current

44.7(42.1, 47.4)

42.2 (38.6, 46.3)

0.56 (0.46, 0.66)

0.63 (0.49, 0.76)

ref

1.12 (0.95, 1.29)

ref

6.8 (−2.4, 16)

Table 3.

Open in new tab

Median Age at MetS Onset and Relative Risk as Predicted by Models 1 and 3 in Table 2

			Predicted Median Age at Onset  (95% CI)		Predicted Risk from Age 40 to 50  (95% CI)		Predicted Risk Ratio from Age 40 to 50  (95% CI)		Predicted Risk Difference (in Percentage Points) from Age 40 to 50  (95% CI)
			Not PCOSp	PCOSp	Not PCOSp	PCOSp	Not PCOSp	PCOSp	Not PCOSp	PCOSp
For all women, regardless of covariates:
Model 1^a			54.5 (52.5, 56.7)	47.4 (43.0, 52.3)	0.27 (0.23, 0.31)	0.37 (0.29, 0.46)	ref	1.38 (1.08, 1.69)	ref	10.3 (2.3, 18.3)
For women with a mean covariate profile^c:
Model 3^b			51.5 (49.5, 53.5)	48.7 (45.1, 52.6)	0.37 (0.30, 0.43)	0.44 (0.33, 0.56)	ref	1.21 (0.91, 1.51)	ref	7.7 (−3.1, 18.4)
For women with specified combinations of BMI and smoking status, adjusted for education and physical activity^d:
	$\bar{BMI}$ _38–54	Smoking
Model 3	Normal	Never	65.1 (61.7, 68.9)	61.5 (56.4, 67.2)	0.10 (0.07, 0.14)	0.15 (0.07, 0.23)	ref	1.46 (0.70, 2.22)	ref	4.8 (−2.4, 12)
	Normal	Current	63.5 (59.1, 68.2)	60.1 (54.1, 66.7)	0.12 (0.07, 0.18)	0.18 (0.07, 0.28)	ref	1.43 (0.74, 2.12)	ref	5.3 (−2.8, 13.3)
	Obese	Never	45.7 (43.9, 47.6)	43.3 (40.1, 46.7)	0.53 (0.45, 0.6)	0.60 (0.48, 0.72)	ref	1.13 (0.95, 1.32)	ref	7.1 (−2.6, 16.7)
	Obese	Current	44.7(42.1, 47.4)	42.2 (38.6, 46.3)	0.56 (0.46, 0.66)	0.63 (0.49, 0.76)	ref	1.12 (0.95, 1.29)	ref	6.8 (−2.4, 16)

			Predicted Median Age at Onset  (95% CI)		Predicted Risk from Age 40 to 50  (95% CI)		Predicted Risk Ratio from Age 40 to 50  (95% CI)		Predicted Risk Difference (in Percentage Points) from Age 40 to 50  (95% CI)
			Not PCOSp	PCOSp	Not PCOSp	PCOSp	Not PCOSp	PCOSp	Not PCOSp	PCOSp
For all women, regardless of covariates:
Model 1^a			54.5 (52.5, 56.7)	47.4 (43.0, 52.3)	0.27 (0.23, 0.31)	0.37 (0.29, 0.46)	ref	1.38 (1.08, 1.69)	ref	10.3 (2.3, 18.3)
For women with a mean covariate profile^c:
Model 3^b			51.5 (49.5, 53.5)	48.7 (45.1, 52.6)	0.37 (0.30, 0.43)	0.44 (0.33, 0.56)	ref	1.21 (0.91, 1.51)	ref	7.7 (−3.1, 18.4)
For women with specified combinations of BMI and smoking status, adjusted for education and physical activity^d:
	$\bar{BMI}$ _38–54	Smoking
Model 3	Normal	Never	65.1 (61.7, 68.9)	61.5 (56.4, 67.2)	0.10 (0.07, 0.14)	0.15 (0.07, 0.23)	ref	1.46 (0.70, 2.22)	ref	4.8 (−2.4, 12)
	Normal	Current	63.5 (59.1, 68.2)	60.1 (54.1, 66.7)	0.12 (0.07, 0.18)	0.18 (0.07, 0.28)	ref	1.43 (0.74, 2.12)	ref	5.3 (−2.8, 13.3)
	Obese	Never	45.7 (43.9, 47.6)	43.3 (40.1, 46.7)	0.53 (0.45, 0.6)	0.60 (0.48, 0.72)	ref	1.13 (0.95, 1.32)	ref	7.1 (−2.6, 16.7)
	Obese	Current	44.7(42.1, 47.4)	42.2 (38.6, 46.3)	0.56 (0.46, 0.66)	0.63 (0.49, 0.76)	ref	1.12 (0.95, 1.29)	ref	6.8 (−2.4, 16)

Bold: P value < 0.05.

Model 1: PCOSp only.

Model 3: Model 1 + smoking, education, physical activity, $\bar{BMI}$ _38–54 and $\bar{BMI}$ _38-54 squared.

Mean covariate profile: covariates were set to be “non-smoker” with mean Visit 2 (1993/1994) level of education (14 years), physical activity (0) and $\bar{BMI}$ _38–54 (29 kg/m²) for all women.

For “Normal BMI,” $\bar{BMI}$ _38–54 was set at the 25th percentile (24 kg/m²). For obese, $\bar{BMI}$ _38–54 was set at the 75th percentile (32.09 kg/m²). Education and physical activity were both set at the mean levels.

This Feature Is Available To Subscribers Only