Summary odds ratios (OR) and 95% confidence intervals (CI) for the association between a 1-unit increase in the weighted genetic risk score (the instrumental variable for height) and risk of colorectal cancer (CRC), colon cancer and rectal cancera
| Site . | All . | Women . | Men . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | |
| Colorectal cancer | 10226/10286 | 1.07 (1.01–1.14) | 0% | 5644/5747 | 1.09 (1.01–1.19) | 0% | 4582/4539 | 1.05 (0.96–1.15) | 0% |
| Colon cancer | 6864/10286 | 1.05 (0.98–1.12) | 0% | 3922/5747 | 1.04 (0.95–1.14) | 0% | 2942/4539 | 1.06 (0.96–1.17) | 0% |
| Rectal cancer | 2365/10286 | 1.09 (0.98–1.20) | 0% | 1112/5747 | 1.05 (0.90–1.22) | 0% | 1253/4539 | 1.13 (0.98–1.31) | 0% |
| Site . | All . | Women . | Men . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | |
| Colorectal cancer | 10226/10286 | 1.07 (1.01–1.14) | 0% | 5644/5747 | 1.09 (1.01–1.19) | 0% | 4582/4539 | 1.05 (0.96–1.15) | 0% |
| Colon cancer | 6864/10286 | 1.05 (0.98–1.12) | 0% | 3922/5747 | 1.04 (0.95–1.14) | 0% | 2942/4539 | 1.06 (0.96–1.17) | 0% |
| Rectal cancer | 2365/10286 | 1.09 (0.98–1.20) | 0% | 1112/5747 | 1.05 (0.90–1.22) | 0% | 1253/4539 | 1.13 (0.98–1.31) | 0% |
Summary odds ratios were estimated using a random effects meta-analytical model.
aNot all cases from CRC analyses were included in the site-specific analyses (i.e. where we did not have site data for analysis).
bAdjusted for age (continuous) and the top three principal components of ancestry.
Summary odds ratios (OR) and 95% confidence intervals (CI) for the association between a 1-unit increase in the weighted genetic risk score (the instrumental variable for height) and risk of colorectal cancer (CRC), colon cancer and rectal cancera
| Site . | All . | Women . | Men . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | |
| Colorectal cancer | 10226/10286 | 1.07 (1.01–1.14) | 0% | 5644/5747 | 1.09 (1.01–1.19) | 0% | 4582/4539 | 1.05 (0.96–1.15) | 0% |
| Colon cancer | 6864/10286 | 1.05 (0.98–1.12) | 0% | 3922/5747 | 1.04 (0.95–1.14) | 0% | 2942/4539 | 1.06 (0.96–1.17) | 0% |
| Rectal cancer | 2365/10286 | 1.09 (0.98–1.20) | 0% | 1112/5747 | 1.05 (0.90–1.22) | 0% | 1253/4539 | 1.13 (0.98–1.31) | 0% |
| Site . | All . | Women . | Men . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | Cases/Controls . | ORb (95% CI) . | I2 . | |
| Colorectal cancer | 10226/10286 | 1.07 (1.01–1.14) | 0% | 5644/5747 | 1.09 (1.01–1.19) | 0% | 4582/4539 | 1.05 (0.96–1.15) | 0% |
| Colon cancer | 6864/10286 | 1.05 (0.98–1.12) | 0% | 3922/5747 | 1.04 (0.95–1.14) | 0% | 2942/4539 | 1.06 (0.96–1.17) | 0% |
| Rectal cancer | 2365/10286 | 1.09 (0.98–1.20) | 0% | 1112/5747 | 1.05 (0.90–1.22) | 0% | 1253/4539 | 1.13 (0.98–1.31) | 0% |
Summary odds ratios were estimated using a random effects meta-analytical model.
aNot all cases from CRC analyses were included in the site-specific analyses (i.e. where we did not have site data for analysis).
bAdjusted for age (continuous) and the top three principal components of ancestry.
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