On multivariate logistic regression analysis, predictors of any complication in derivation cohort include age ≥65 years, female gender, emergency admission, CAD, coagulopathy, CLD, CKD, CVA, and PVD, which constituted our ‘risk score model’ (see Table 3). Hypertension, diabetes, obesity, CHF, and COPD were significant predictors on univariate, but not on multivariate analysis. The assigned risk score (in parenthesis) for each of these multivariate predictors in the descending order of significance include CKD (5), coagulopathy (5), CLD (5), CVA (3), emergency procedure (3), age ≥ 65 years (2), CAD (2), PVD (1), and female gender (1) with a combined total score of 27. The whole cohort was divided into four groups based on the combined total score: Group 0 with the risk score of 0, Group 1 with risk score from 1 to 5, Group 2 with risk score from 6 to 10, and Group 3 with risk score from 11 to 27. Group 3 includes wider range of scores from 11 to 27 due to the progressively fewer number of patients at higher risk scores. The comparison of complication rates by risk score groups in whole sample were depicted in Table 4 and Figure 1 and in validation cohort were depicted in Supplementary material online, Appendix (Table 7, Figures 3 and 4).

Table 3

Predictors of ‘any complications’ with assigned risk score

Risk scorePredictorsBeta coefficientOdds ratio95% confidence intervalP-value
5Coagulopathy1.072.92.40–3.51<0.001
5Chronic liver disease0.932.521.69–3.75<0.001
5Chronic kidney disease and electrolyte abnormalities0.962.622.35–2.92<0.001
3Emergency admission0.381.461.29–1.64<0.001
3Cerebrovascular accident0.721.27–3.150.003
2Age>65 years0.341.41.25–1.57<0.001
2Coronary artery disease0.341.411.25–1.58<0.001
1Peripheral vascular disease0.21.251.1–1.460.007
1Female sex0.231.261.11–1.42<0.001
27Total risk score
Risk scorePredictorsBeta coefficientOdds ratio95% confidence intervalP-value
5Coagulopathy1.072.92.40–3.51<0.001
5Chronic liver disease0.932.521.69–3.75<0.001
5Chronic kidney disease and electrolyte abnormalities0.962.622.35–2.92<0.001
3Emergency admission0.381.461.29–1.64<0.001
3Cerebrovascular accident0.721.27–3.150.003
2Age>65 years0.341.41.25–1.57<0.001
2Coronary artery disease0.341.411.25–1.58<0.001
1Peripheral vascular disease0.21.251.1–1.460.007
1Female sex0.231.261.11–1.42<0.001
27Total risk score
Table 3

Predictors of ‘any complications’ with assigned risk score

Risk scorePredictorsBeta coefficientOdds ratio95% confidence intervalP-value
5Coagulopathy1.072.92.40–3.51<0.001
5Chronic liver disease0.932.521.69–3.75<0.001
5Chronic kidney disease and electrolyte abnormalities0.962.622.35–2.92<0.001
3Emergency admission0.381.461.29–1.64<0.001
3Cerebrovascular accident0.721.27–3.150.003
2Age>65 years0.341.41.25–1.57<0.001
2Coronary artery disease0.341.411.25–1.58<0.001
1Peripheral vascular disease0.21.251.1–1.460.007
1Female sex0.231.261.11–1.42<0.001
27Total risk score
Risk scorePredictorsBeta coefficientOdds ratio95% confidence intervalP-value
5Coagulopathy1.072.92.40–3.51<0.001
5Chronic liver disease0.932.521.69–3.75<0.001
5Chronic kidney disease and electrolyte abnormalities0.962.622.35–2.92<0.001
3Emergency admission0.381.461.29–1.64<0.001
3Cerebrovascular accident0.721.27–3.150.003
2Age>65 years0.341.41.25–1.57<0.001
2Coronary artery disease0.341.411.25–1.58<0.001
1Peripheral vascular disease0.21.251.1–1.460.007
1Female sex0.231.261.11–1.42<0.001
27Total risk score
Table 4

Comparison of complication rates between different risk score groups in whole sample

VariablesRisk group (risk score range)
P-value
0 (0)1 (1–5)2 (6–10)3 (11–27)
(N = 1728)(N = 14 202)(N = 6742)(N = 2757)
All vascular complications (%)37 (2.1)784 (5.5)841 (12.5)586 (21)<0.01
 Post-procedural haemorrhage (%)27 (1.5)422 (3.0)321 (4.8)187 (6.8)<0.01
 Post-procedural haemorrhage requiring transfusions (%)10 (0.6)327 (2.3)489 (7.3)403 (15)<0.01
 Iatrogenic vascular injury (%)10 (0.6)130 (0.9)127 (1.9)67 (2.4)<0.01
 Vascular injury requiring surgery (%)040 (0.3)76 (1.1)34 (1.2)<0.01
All cardiac complications (%)15 (0.9)739 (5.2)594 (8.8)329 (12)<0.01
 Hemopericardium (%)029 (0.2)26 (0.4)16 (0.6)<0.01
 Cardiac tamponade (%)10 (0.6)134 (0.9)81 (1.2)35 (1.3)0.01
 Myocardial infarction (%)5 (0.3)382 (2.7)354 (5.3)248 (9)<0.01
 Iatrogenic cardiac complications (%)0277 (2)204 (3)60 (2.2)<0.01
Cardiac complications requiring surgery (%)5 (0.3)95 (0.7)137 (2)71 (2.6)<0.01
All pulmonary complications (%)5 (0.3)39 (0.3)32 (0.5)21 (0.8)0.08
Cerebrovascular accident (%)5 (0.3)66 (0.5)112 (1.7)46 (1.7)<0.01
Shock (%)010 (0.1)20 (0.3)22 (0.8)<0.01
Septicaemia (%)053 (0.4)88 (1.3)65 (2.4)<0.01
In-hospital mortality (%)0124 (0.9)295 (4.4)282 (10)<0.01
Any complications (%)47 (2.7)1451 (10.2)1388 (21)849 (31)<0.01
VariablesRisk group (risk score range)
P-value
0 (0)1 (1–5)2 (6–10)3 (11–27)
(N = 1728)(N = 14 202)(N = 6742)(N = 2757)
All vascular complications (%)37 (2.1)784 (5.5)841 (12.5)586 (21)<0.01
 Post-procedural haemorrhage (%)27 (1.5)422 (3.0)321 (4.8)187 (6.8)<0.01
 Post-procedural haemorrhage requiring transfusions (%)10 (0.6)327 (2.3)489 (7.3)403 (15)<0.01
 Iatrogenic vascular injury (%)10 (0.6)130 (0.9)127 (1.9)67 (2.4)<0.01
 Vascular injury requiring surgery (%)040 (0.3)76 (1.1)34 (1.2)<0.01
All cardiac complications (%)15 (0.9)739 (5.2)594 (8.8)329 (12)<0.01
 Hemopericardium (%)029 (0.2)26 (0.4)16 (0.6)<0.01
 Cardiac tamponade (%)10 (0.6)134 (0.9)81 (1.2)35 (1.3)0.01
 Myocardial infarction (%)5 (0.3)382 (2.7)354 (5.3)248 (9)<0.01
 Iatrogenic cardiac complications (%)0277 (2)204 (3)60 (2.2)<0.01
Cardiac complications requiring surgery (%)5 (0.3)95 (0.7)137 (2)71 (2.6)<0.01
All pulmonary complications (%)5 (0.3)39 (0.3)32 (0.5)21 (0.8)0.08
Cerebrovascular accident (%)5 (0.3)66 (0.5)112 (1.7)46 (1.7)<0.01
Shock (%)010 (0.1)20 (0.3)22 (0.8)<0.01
Septicaemia (%)053 (0.4)88 (1.3)65 (2.4)<0.01
In-hospital mortality (%)0124 (0.9)295 (4.4)282 (10)<0.01
Any complications (%)47 (2.7)1451 (10.2)1388 (21)849 (31)<0.01
Table 4

Comparison of complication rates between different risk score groups in whole sample

VariablesRisk group (risk score range)
P-value
0 (0)1 (1–5)2 (6–10)3 (11–27)
(N = 1728)(N = 14 202)(N = 6742)(N = 2757)
All vascular complications (%)37 (2.1)784 (5.5)841 (12.5)586 (21)<0.01
 Post-procedural haemorrhage (%)27 (1.5)422 (3.0)321 (4.8)187 (6.8)<0.01
 Post-procedural haemorrhage requiring transfusions (%)10 (0.6)327 (2.3)489 (7.3)403 (15)<0.01
 Iatrogenic vascular injury (%)10 (0.6)130 (0.9)127 (1.9)67 (2.4)<0.01
 Vascular injury requiring surgery (%)040 (0.3)76 (1.1)34 (1.2)<0.01
All cardiac complications (%)15 (0.9)739 (5.2)594 (8.8)329 (12)<0.01
 Hemopericardium (%)029 (0.2)26 (0.4)16 (0.6)<0.01
 Cardiac tamponade (%)10 (0.6)134 (0.9)81 (1.2)35 (1.3)0.01
 Myocardial infarction (%)5 (0.3)382 (2.7)354 (5.3)248 (9)<0.01
 Iatrogenic cardiac complications (%)0277 (2)204 (3)60 (2.2)<0.01
Cardiac complications requiring surgery (%)5 (0.3)95 (0.7)137 (2)71 (2.6)<0.01
All pulmonary complications (%)5 (0.3)39 (0.3)32 (0.5)21 (0.8)0.08
Cerebrovascular accident (%)5 (0.3)66 (0.5)112 (1.7)46 (1.7)<0.01
Shock (%)010 (0.1)20 (0.3)22 (0.8)<0.01
Septicaemia (%)053 (0.4)88 (1.3)65 (2.4)<0.01
In-hospital mortality (%)0124 (0.9)295 (4.4)282 (10)<0.01
Any complications (%)47 (2.7)1451 (10.2)1388 (21)849 (31)<0.01
VariablesRisk group (risk score range)
P-value
0 (0)1 (1–5)2 (6–10)3 (11–27)
(N = 1728)(N = 14 202)(N = 6742)(N = 2757)
All vascular complications (%)37 (2.1)784 (5.5)841 (12.5)586 (21)<0.01
 Post-procedural haemorrhage (%)27 (1.5)422 (3.0)321 (4.8)187 (6.8)<0.01
 Post-procedural haemorrhage requiring transfusions (%)10 (0.6)327 (2.3)489 (7.3)403 (15)<0.01
 Iatrogenic vascular injury (%)10 (0.6)130 (0.9)127 (1.9)67 (2.4)<0.01
 Vascular injury requiring surgery (%)040 (0.3)76 (1.1)34 (1.2)<0.01
All cardiac complications (%)15 (0.9)739 (5.2)594 (8.8)329 (12)<0.01
 Hemopericardium (%)029 (0.2)26 (0.4)16 (0.6)<0.01
 Cardiac tamponade (%)10 (0.6)134 (0.9)81 (1.2)35 (1.3)0.01
 Myocardial infarction (%)5 (0.3)382 (2.7)354 (5.3)248 (9)<0.01
 Iatrogenic cardiac complications (%)0277 (2)204 (3)60 (2.2)<0.01
Cardiac complications requiring surgery (%)5 (0.3)95 (0.7)137 (2)71 (2.6)<0.01
All pulmonary complications (%)5 (0.3)39 (0.3)32 (0.5)21 (0.8)0.08
Cerebrovascular accident (%)5 (0.3)66 (0.5)112 (1.7)46 (1.7)<0.01
Shock (%)010 (0.1)20 (0.3)22 (0.8)<0.01
Septicaemia (%)053 (0.4)88 (1.3)65 (2.4)<0.01
In-hospital mortality (%)0124 (0.9)295 (4.4)282 (10)<0.01
Any complications (%)47 (2.7)1451 (10.2)1388 (21)849 (31)<0.01

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