Crudely, there was a slight suggestion of a U- or J-shaped relationship between BW and BP (Figure 2). Compared with those with BW 3.00–3.49 kg, the difference in adjusted mean systolic BP was +0.30 mmHg, 95% CI (−1.87, +2.47), −0.07 mmHg, 95% CI (−1.50, +1.35) and +0.78 mmHg, 95% CI (−0.56, +2.11) among those with BW <2.5 kg, 2.5–2.99 kg and ≥3.5 kg, respectively (Supplementary Table 3, available as Supplementary data at IJE online). However, confidence intervals were wide and treating BW as a categorical variable in the regression model did not improve the fit of the model to the data compared with a linear model (P-values for departure from linearity 0.253 and 0.404 for systolic and diastolic BP, respectively). Regardless of whether or not BW was modelled as categorical or linear, there was no evidence for association between BW and BP; for example, linear model regression coefficients were β = 0.14, 95% CI (-1.00, 1.27) for systolic and β = 0.43, 95% CI (-0.57, 1.43) for diastolic BP (Table 1).

Table 1

Crude and adjusted effect of birth weight on blood pressure among Entebbe Mother and Baby Study adolescents

Blood pressureNumberMean birth weight (Kg)Mean BP (mmHg)Crude association
Adjusted association
β (95% CI)β (95% CI)β (95% CI)c
Systolic BP11193.19105.870.73 (−0.33, 1.80)0.14 (−1.00, 1.27)a−0.91 (−1.99, 0.18)
Diastolic BP11193.1965.200.66 (−0.27, 1.59)0.43 (−0.57, 1.43)b−0.35 (−1.32, 0.61)
Blood pressureNumberMean birth weight (Kg)Mean BP (mmHg)Crude association
Adjusted association
β (95% CI)β (95% CI)β (95% CI)c
Systolic BP11193.19105.870.73 (−0.33, 1.80)0.14 (−1.00, 1.27)a−0.91 (−1.99, 0.18)
Diastolic BP11193.1965.200.66 (−0.27, 1.59)0.43 (−0.57, 1.43)b−0.35 (−1.32, 0.61)

β; linear regression coefficient: mean difference in blood pressure measured in mmHg per 1 kg increase in birth weight, CI: confidence interval.

a

Adjusted for maternal factors at enrolment (age, household socioeconomic status, body mass index, asymptomatic malaria, education, parity) and child factors (sex, age, family history of blood pressure).

b

Adjusted for maternal factors at enrolment (age, household socioeconomic status, body mass index, asymptomatic malaria, education, parity) and child factors (sex, age, asymptomatic malaria, family history of blood pressure).

c

Additionally adjusted for current weight.

Table 1

Crude and adjusted effect of birth weight on blood pressure among Entebbe Mother and Baby Study adolescents

Blood pressureNumberMean birth weight (Kg)Mean BP (mmHg)Crude association
Adjusted association
β (95% CI)β (95% CI)β (95% CI)c
Systolic BP11193.19105.870.73 (−0.33, 1.80)0.14 (−1.00, 1.27)a−0.91 (−1.99, 0.18)
Diastolic BP11193.1965.200.66 (−0.27, 1.59)0.43 (−0.57, 1.43)b−0.35 (−1.32, 0.61)
Blood pressureNumberMean birth weight (Kg)Mean BP (mmHg)Crude association
Adjusted association
β (95% CI)β (95% CI)β (95% CI)c
Systolic BP11193.19105.870.73 (−0.33, 1.80)0.14 (−1.00, 1.27)a−0.91 (−1.99, 0.18)
Diastolic BP11193.1965.200.66 (−0.27, 1.59)0.43 (−0.57, 1.43)b−0.35 (−1.32, 0.61)

β; linear regression coefficient: mean difference in blood pressure measured in mmHg per 1 kg increase in birth weight, CI: confidence interval.

a

Adjusted for maternal factors at enrolment (age, household socioeconomic status, body mass index, asymptomatic malaria, education, parity) and child factors (sex, age, family history of blood pressure).

b

Adjusted for maternal factors at enrolment (age, household socioeconomic status, body mass index, asymptomatic malaria, education, parity) and child factors (sex, age, asymptomatic malaria, family history of blood pressure).

c

Additionally adjusted for current weight.

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