Over a 32 month period, the OPAT service received 781 patient referrals, of which 243 were not accepted, most commonly (158, 65%) owing to infection specialist assessment that iv antimicrobials were not indicated, including the availability of oral alternatives (Table S1, available as Supplementary data at JAC Online). Consequently, we present data from 538 patients resulting in 544 episodes of OPAT patient care. The median age was 57 (IQR 39–71) years, 60% of the cohort was male and 13% had diabetes mellitus. The median duration of an OPAT care episode was 7 days (IQR 2–18), but was dependent on the OPAT indications, the commonest being skin and soft tissue infections (32% of episodes) (Table S2). The three most frequent antimicrobials used were ceftriaxone, teicoplanin and ertapenem (Table S3) and midline catheters accounted for over half the total indwelling iv catheter duration (Table S4). Overall, OPAT was judged to be a full/partial success in 93% of episodes. A total of 35 patients (6.4%) required readmission and there were two deaths (0.4%).