Comparison of Outcomes During Follow-Up (From 1998–2001 To 2014) Between the MHO and MUO Subphenotypes, Among Participants With Complete Data From Baseline to Last Examination (1987–1991 to 1998–2001)
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 9/156 | 0.18 (0.09–0.35) | 0.18 (0.09–0.37) |
| Hypertension (2014 JNC-8 criteria) | 77/135 | 0.86 (0.57–1.30) | 0.90 (0.59–1.37) |
| Hypertension (2017 ACC/AHA criteria) | 67/96 | 1.20 (0.69–2.10) | 1.26 (0.72–2.22) |
| CKD/microalbuminuria | 17/112 | 0.35 (0.20–0.60) | 0.43 (0.24–0.76) |
| CVD | 20/159 | 0.40 (0.25–0.65) | 0.53 (0.33–0.86) |
| Cancer mortality | 13/172 | 0.73 (0.40–1.34) | 1.00 (0.54–1.85) |
| Cardiovascular mortality | 3/172 | 0.26 (0.08–0.84) | 0.48 (0.15–1.58) |
| All-cause mortality | 24/172 | 0.49 (0.32–0.76) | 0.81 (0.53–1.25) |
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 9/156 | 0.18 (0.09–0.35) | 0.18 (0.09–0.37) |
| Hypertension (2014 JNC-8 criteria) | 77/135 | 0.86 (0.57–1.30) | 0.90 (0.59–1.37) |
| Hypertension (2017 ACC/AHA criteria) | 67/96 | 1.20 (0.69–2.10) | 1.26 (0.72–2.22) |
| CKD/microalbuminuria | 17/112 | 0.35 (0.20–0.60) | 0.43 (0.24–0.76) |
| CVD | 20/159 | 0.40 (0.25–0.65) | 0.53 (0.33–0.86) |
| Cancer mortality | 13/172 | 0.73 (0.40–1.34) | 1.00 (0.54–1.85) |
| Cardiovascular mortality | 3/172 | 0.26 (0.08–0.84) | 0.48 (0.15–1.58) |
| All-cause mortality | 24/172 | 0.49 (0.32–0.76) | 0.81 (0.53–1.25) |
HRs are from the models in Table 8 relating all obesity phenotypes to subclinical outcomes but with MUO as the reference group; only the MHO vs MUO comparisons are shown.
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8: Eighth Joint National Committee.
Adjusted for age, sex, and current smoking.
Comparison of Outcomes During Follow-Up (From 1998–2001 To 2014) Between the MHO and MUO Subphenotypes, Among Participants With Complete Data From Baseline to Last Examination (1987–1991 to 1998–2001)
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 9/156 | 0.18 (0.09–0.35) | 0.18 (0.09–0.37) |
| Hypertension (2014 JNC-8 criteria) | 77/135 | 0.86 (0.57–1.30) | 0.90 (0.59–1.37) |
| Hypertension (2017 ACC/AHA criteria) | 67/96 | 1.20 (0.69–2.10) | 1.26 (0.72–2.22) |
| CKD/microalbuminuria | 17/112 | 0.35 (0.20–0.60) | 0.43 (0.24–0.76) |
| CVD | 20/159 | 0.40 (0.25–0.65) | 0.53 (0.33–0.86) |
| Cancer mortality | 13/172 | 0.73 (0.40–1.34) | 1.00 (0.54–1.85) |
| Cardiovascular mortality | 3/172 | 0.26 (0.08–0.84) | 0.48 (0.15–1.58) |
| All-cause mortality | 24/172 | 0.49 (0.32–0.76) | 0.81 (0.53–1.25) |
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 9/156 | 0.18 (0.09–0.35) | 0.18 (0.09–0.37) |
| Hypertension (2014 JNC-8 criteria) | 77/135 | 0.86 (0.57–1.30) | 0.90 (0.59–1.37) |
| Hypertension (2017 ACC/AHA criteria) | 67/96 | 1.20 (0.69–2.10) | 1.26 (0.72–2.22) |
| CKD/microalbuminuria | 17/112 | 0.35 (0.20–0.60) | 0.43 (0.24–0.76) |
| CVD | 20/159 | 0.40 (0.25–0.65) | 0.53 (0.33–0.86) |
| Cancer mortality | 13/172 | 0.73 (0.40–1.34) | 1.00 (0.54–1.85) |
| Cardiovascular mortality | 3/172 | 0.26 (0.08–0.84) | 0.48 (0.15–1.58) |
| All-cause mortality | 24/172 | 0.49 (0.32–0.76) | 0.81 (0.53–1.25) |
HRs are from the models in Table 8 relating all obesity phenotypes to subclinical outcomes but with MUO as the reference group; only the MHO vs MUO comparisons are shown.
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8: Eighth Joint National Committee.
Adjusted for age, sex, and current smoking.
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