Comparison of Outcomes During Follow-Up (from 1998–2001 to 2014) Between the MHO and MUO Subphenotypes
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 13/220 | 0.20 (0.11–0.36) | 0.21 (0.12–0.39) |
| Hypertension (2014 JNC-8 criteria) | 98/189 | 0.72 (0.51–1.02) | 0.77 (0.54–1.11) |
| Hypertension (2017 ACC/AHA criteria) | 86/133 | 1.03 (0.64–1.67) | 1.09 (0.67–1.78) |
| CKD/microalbuminuria | 22/162 | 0.33 (0.21–0.54) | 0.44 (0.27–0.73) |
| CVD | 29/227 | 0.47 (0.32–0.70) | 0.64 (0.43–0.95) |
| Cancer mortality | 16/243 | 0.67 (0.39–1.16) | 0.92 (0.53–1.59) |
| Cardiovascular mortality | 6/243 | 0.38 (0.16–0.90) | 0.67 (0.29–1.59) |
| All-cause mortality | 34/243 | 0.54 (0.37–0.78) | 0.86 (0.59–1.24) |
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 13/220 | 0.20 (0.11–0.36) | 0.21 (0.12–0.39) |
| Hypertension (2014 JNC-8 criteria) | 98/189 | 0.72 (0.51–1.02) | 0.77 (0.54–1.11) |
| Hypertension (2017 ACC/AHA criteria) | 86/133 | 1.03 (0.64–1.67) | 1.09 (0.67–1.78) |
| CKD/microalbuminuria | 22/162 | 0.33 (0.21–0.54) | 0.44 (0.27–0.73) |
| CVD | 29/227 | 0.47 (0.32–0.70) | 0.64 (0.43–0.95) |
| Cancer mortality | 16/243 | 0.67 (0.39–1.16) | 0.92 (0.53–1.59) |
| Cardiovascular mortality | 6/243 | 0.38 (0.16–0.90) | 0.67 (0.29–1.59) |
| All-cause mortality | 34/243 | 0.54 (0.37–0.78) | 0.86 (0.59–1.24) |
HRs are from the models in Table 7 relating all obesity phenotypes to subclinical outcomes but with MUO as the reference group; only the MHO vs MUO comparisons are shown.
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8: Eighth Joint National Committee.
Adjusted for age, sex, and current smoking.
Comparison of Outcomes During Follow-Up (from 1998–2001 to 2014) Between the MHO and MUO Subphenotypes
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 13/220 | 0.20 (0.11–0.36) | 0.21 (0.12–0.39) |
| Hypertension (2014 JNC-8 criteria) | 98/189 | 0.72 (0.51–1.02) | 0.77 (0.54–1.11) |
| Hypertension (2017 ACC/AHA criteria) | 86/133 | 1.03 (0.64–1.67) | 1.09 (0.67–1.78) |
| CKD/microalbuminuria | 22/162 | 0.33 (0.21–0.54) | 0.44 (0.27–0.73) |
| CVD | 29/227 | 0.47 (0.32–0.70) | 0.64 (0.43–0.95) |
| Cancer mortality | 16/243 | 0.67 (0.39–1.16) | 0.92 (0.53–1.59) |
| Cardiovascular mortality | 6/243 | 0.38 (0.16–0.90) | 0.67 (0.29–1.59) |
| All-cause mortality | 34/243 | 0.54 (0.37–0.78) | 0.86 (0.59–1.24) |
| Outcomes . | Obesity Subphenotypes at Examination 7 (in 1998–2001) . | ||
|---|---|---|---|
| Events/n in MHO Group . | Unadjusted HR (95% CI) . | Adjusted HR (95% CI)a . | |
| Type 2 diabetes | 13/220 | 0.20 (0.11–0.36) | 0.21 (0.12–0.39) |
| Hypertension (2014 JNC-8 criteria) | 98/189 | 0.72 (0.51–1.02) | 0.77 (0.54–1.11) |
| Hypertension (2017 ACC/AHA criteria) | 86/133 | 1.03 (0.64–1.67) | 1.09 (0.67–1.78) |
| CKD/microalbuminuria | 22/162 | 0.33 (0.21–0.54) | 0.44 (0.27–0.73) |
| CVD | 29/227 | 0.47 (0.32–0.70) | 0.64 (0.43–0.95) |
| Cancer mortality | 16/243 | 0.67 (0.39–1.16) | 0.92 (0.53–1.59) |
| Cardiovascular mortality | 6/243 | 0.38 (0.16–0.90) | 0.67 (0.29–1.59) |
| All-cause mortality | 34/243 | 0.54 (0.37–0.78) | 0.86 (0.59–1.24) |
HRs are from the models in Table 7 relating all obesity phenotypes to subclinical outcomes but with MUO as the reference group; only the MHO vs MUO comparisons are shown.
Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; JNC-8: Eighth Joint National Committee.
Adjusted for age, sex, and current smoking.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
