Table 3. Open in new tab Relative...

Table 3.

Relative Contribution of CD4⁺ and CD68⁺ Cells to the Expression of IL-4 and IL-10, Respectively, in Lesions From Pregnant and Nonpregnant Women With Cutaneous Leishmaniasis

Parameter	Nonpregnant CL (n = 6)	Pregnant CL (n = 7)
Number of IL-4⁺ cells	265 ± 230^a	629 ± 377^a
Number of CD4⁺IL-4⁺ cells	126 ± 25^a	405 ± 258^a
Relative contribution of CD4⁺ cells to IL-4 expression	67 ± 28	68 ± 18
Number of IL-10⁺ cells	160 ± 130^a	558 ± 382^a
Number of CD68⁺IL-10⁺ cells	56 ± 50	302 ± 253
Relative contribution of CD68⁺ cells to IL-10 expression	38 ± 34	62 ± 23

Parameter	Nonpregnant CL (n = 6)	Pregnant CL (n = 7)
Number of IL-4⁺ cells	265 ± 230^a	629 ± 377^a
Number of CD4⁺IL-4⁺ cells	126 ± 25^a	405 ± 258^a
Relative contribution of CD4⁺ cells to IL-4 expression	67 ± 28	68 ± 18
Number of IL-10⁺ cells	160 ± 130^a	558 ± 382^a
Number of CD68⁺IL-10⁺ cells	56 ± 50	302 ± 253
Relative contribution of CD68⁺ cells to IL-10 expression	38 ± 34	62 ± 23

Numbers of cells were counted based on the expression of specific fluorescent markers for either IL-4 or IL-10 alone, a combination of IL-4 and CD4 or IL-10 and CD68, as indicated and described in Methods. The relative contributions of CD4⁺ and CD68⁺ cells to IL-4 and IL-10 expression, respectively, were calculated as the percentage of CD4⁺ or CD68⁺ cells expressing each cytokine in relation to the total expression of that given cytokine.

The numbers are expressed in mean ± SD. The Relative contribution is expressed in percentage.

Abbreviation: CL, cutaneous leishmaniasis; IL, interleukin.

^aStatistically significant differences between pregnant and nonpregnant CL groups, P < .05.

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