Table 1. Open in new tab Transcripts...

	Upregulated	Downregulated
Experiment 1
12-day high Cort	Hif3a	Hypoxia-inducible factor 3-α	7.00	Crh	Corticotropin-releasing factor	0.27
	Pla2g3	Group 3 secretory phospholipase A2	4.61	Fcrl2	Fc receptor-like protein 2	0.29
	Gpd1	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	3.73	Pcdh12	Protocadherin-12	0.30
	LOC102723236		3.32	Polq	DNA polymerase θ	0.32
	Fmo2	Dimethyaniline monooxygenase [N-oxide-forming] 2	3.16	Mmp14	Matrix metalloproteinase-14	0.40
	Sgk1	Serine/threonine-protein kinase Sgk1	2.77	Cd93	Compliment component C1q receptor	0.45
	Rn5-8s	5.8S ribosomal RNA	2.73	Igf2	Insulin-like growth factor 2	0.47
	Ctgf	Connective tissue growth factor	2.64	Fabp7	Fatty acid-binding protein, brain	0.48
	Sult1a1	Sulfotransferase 1A1	2.56
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130	2.52
	Fst	Follistatin	2.47
	Gjb2	Gap junction β-2 protein	2.39
	Slc19a3	Thiamine transporter 2	2.24
	Zbtb16	Zinc finger and BTB domain-containing protein 16	2.12
	LOC310926		2.12
	Rn18s,Rn45s	18S ribosomal RNA	2.11
7-day ADX	Crh	Corticotropin-releasing factor	2.21	RT1-N2		0.25
	Clca1	Calcium-activated chloride channel regulator 1	2.10	Vip	Vasoactive intestinal polypeptide	0.34
				Ifit1	Interferon-induced protein with tetratricopeptide repeats 1	0.38
				Acsm5	Acyl-coenzyme A synthetase ACSM5, mitochondrial	0.39
				Sult1a1	Sulfotransferase 1A1	0.45
				Gabrd	Gamma-aminobutyric acid receptor subunit δ	0.49
Experiment 2
Acute Cort (1) 1 h	Bsx	Brain-specific homeobox protein homolog	2.60	Rn5-8s	5.8S ribosomal RNA	0.18
	Nr4a3	Nuclear receptor subfamily 4 group A member 3	2.58	Mybpc1	Myosin-binding protein C, slow-type	0.27
	Fos	Proto-oncogene c-Fos	2.03	LOC102723236		0.27
	Fosb	Protein fosB	2.03	Slc17a7	Vesicular glutamate transporter 1	0.35
				LOC310926		0.39
				Rn18s,Rn45s	18S ribosomal RNA	0.42
				Rn28s	28S ribosomal RNA	0.45
				Wnt9b	Protein Wnt-9b	0.46
				Prkcd	Protein kinase C, δ type	0.48
				RGD1560028		0.48
Acute Cort (1) 3 h				LOC102723236		0.28
				Rn5-8s	5.8S ribosomal RNA	0.29
				LOC310926		0.38
				Rn18s	18S ribosomal RNA	0.40
				Slc17a7	Vesicular glutamate transporter 1	0.42
				Rn28s	28S ribosomal RNA	0.44
				Mybpc	Myosin-binding protein C, slow-type	0.49

Upregulated

Downregulated

Gene Symbol

Gene Product

Fold Change

Gene Symbol

Gene Product

Fold Change

Experiment 1

12-day high Cort

Hif3a

Hypoxia-inducible factor 3-α

7.00

Crh

Corticotropin-releasing factor

0.27

Pla2g3

Group 3 secretory phospholipase A2

4.61

Fcrl2

Fc receptor-like protein 2

0.29

Gpd1

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

3.73

Pcdh12

Protocadherin-12

0.30

LOC102723236

3.32

Polq

DNA polymerase θ

0.32

Fmo2

Dimethyaniline monooxygenase [N-oxide-forming] 2

3.16

Mmp14

Matrix metalloproteinase-14

0.40

Sgk1

Serine/threonine-protein kinase Sgk1

2.77

Cd93

Compliment component C1q receptor

0.45

Rn5-8s

5.8S ribosomal RNA

2.73

Igf2

Insulin-like growth factor 2

0.47

Ctgf

Connective tissue growth factor

2.64

Fabp7

Fatty acid-binding protein, brain

0.48

Sult1a1

Sulfotransferase 1A1

2.56

Cd163

Scavenger receptor cysteine-rich type 1 protein M130

2.52

Fst

Follistatin

2.47

Gjb2

Gap junction β-2 protein

2.39

Slc19a3

Thiamine transporter 2

2.24

Zbtb16

Zinc finger and BTB domain-containing protein 16

2.12

LOC310926

2.12

Rn18s,Rn45s

18S ribosomal RNA

2.11

7-day ADX

Crh

Corticotropin-releasing factor

2.21

RT1-N2

0.25

Clca1

Calcium-activated chloride channel regulator 1

2.10

Vip

Vasoactive intestinal polypeptide

0.34

Ifit1

Interferon-induced protein with tetratricopeptide repeats 1

0.38

Acsm5

Acyl-coenzyme A synthetase ACSM5, mitochondrial

0.39

Sult1a1

Sulfotransferase 1A1

0.45

Gabrd

Gamma-aminobutyric acid receptor subunit δ

0.49

Experiment 2

Acute Cort (1) 1 h

Bsx

Brain-specific homeobox protein homolog

2.60

Rn5-8s

5.8S ribosomal RNA

0.18

Nr4a3

Nuclear receptor subfamily 4 group A member 3

2.58

Mybpc1

Myosin-binding protein C, slow-type

0.27

Fos

Proto-oncogene c-Fos

2.03

LOC102723236

0.27

Fosb

Protein fosB

2.03

Slc17a7

Vesicular glutamate transporter 1

0.35

LOC310926

0.39

Rn18s,Rn45s

18S ribosomal RNA

0.42

Rn28s

28S ribosomal RNA

0.45

Wnt9b

Protein Wnt-9b

0.46

Prkcd

Protein kinase C, δ type

0.48

RGD1560028

0.48

Acute Cort (1) 3 h

LOC102723236

0.28

Rn5-8s

5.8S ribosomal RNA

0.29

LOC310926

0.38

Rn18s

18S ribosomal RNA

0.40

Slc17a7

Vesicular glutamate transporter 1

0.42

Rn28s

28S ribosomal RNA

0.44

Mybpc

Myosin-binding protein C, slow-type

0.49

	Upregulated	Downregulated
Experiment 1
12-day high Cort	Hif3a	Hypoxia-inducible factor 3-α	7.00	Crh	Corticotropin-releasing factor	0.27
	Pla2g3	Group 3 secretory phospholipase A2	4.61	Fcrl2	Fc receptor-like protein 2	0.29
	Gpd1	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	3.73	Pcdh12	Protocadherin-12	0.30
	LOC102723236		3.32	Polq	DNA polymerase θ	0.32
	Fmo2	Dimethyaniline monooxygenase [N-oxide-forming] 2	3.16	Mmp14	Matrix metalloproteinase-14	0.40
	Sgk1	Serine/threonine-protein kinase Sgk1	2.77	Cd93	Compliment component C1q receptor	0.45
	Rn5-8s	5.8S ribosomal RNA	2.73	Igf2	Insulin-like growth factor 2	0.47
	Ctgf	Connective tissue growth factor	2.64	Fabp7	Fatty acid-binding protein, brain	0.48
	Sult1a1	Sulfotransferase 1A1	2.56
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130	2.52
	Fst	Follistatin	2.47
	Gjb2	Gap junction β-2 protein	2.39
	Slc19a3	Thiamine transporter 2	2.24
	Zbtb16	Zinc finger and BTB domain-containing protein 16	2.12
	LOC310926		2.12
	Rn18s,Rn45s	18S ribosomal RNA	2.11
7-day ADX	Crh	Corticotropin-releasing factor	2.21	RT1-N2		0.25
	Clca1	Calcium-activated chloride channel regulator 1	2.10	Vip	Vasoactive intestinal polypeptide	0.34
				Ifit1	Interferon-induced protein with tetratricopeptide repeats 1	0.38
				Acsm5	Acyl-coenzyme A synthetase ACSM5, mitochondrial	0.39
				Sult1a1	Sulfotransferase 1A1	0.45
				Gabrd	Gamma-aminobutyric acid receptor subunit δ	0.49
Experiment 2
Acute Cort (1) 1 h	Bsx	Brain-specific homeobox protein homolog	2.60	Rn5-8s	5.8S ribosomal RNA	0.18
	Nr4a3	Nuclear receptor subfamily 4 group A member 3	2.58	Mybpc1	Myosin-binding protein C, slow-type	0.27
	Fos	Proto-oncogene c-Fos	2.03	LOC102723236		0.27
	Fosb	Protein fosB	2.03	Slc17a7	Vesicular glutamate transporter 1	0.35
				LOC310926		0.39
				Rn18s,Rn45s	18S ribosomal RNA	0.42
				Rn28s	28S ribosomal RNA	0.45
				Wnt9b	Protein Wnt-9b	0.46
				Prkcd	Protein kinase C, δ type	0.48
				RGD1560028		0.48
Acute Cort (1) 3 h				LOC102723236		0.28
				Rn5-8s	5.8S ribosomal RNA	0.29
				LOC310926		0.38
				Rn18s	18S ribosomal RNA	0.40
				Slc17a7	Vesicular glutamate transporter 1	0.42
				Rn28s	28S ribosomal RNA	0.44
				Mybpc	Myosin-binding protein C, slow-type	0.49

Table 1.

Open in new tab

Transcripts Most Prominently Affected by Either the Long-Term Changes in Cort or Acute Cort Injection

	Upregulated			Downregulated
	Gene Symbol	Gene Product	Fold Change	Gene Symbol	Gene Product	Fold Change
Experiment 1
12-day high Cort	Hif3a	Hypoxia-inducible factor 3-α	7.00	Crh	Corticotropin-releasing factor	0.27
	Pla2g3	Group 3 secretory phospholipase A2	4.61	Fcrl2	Fc receptor-like protein 2	0.29
	Gpd1	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	3.73	Pcdh12	Protocadherin-12	0.30
	LOC102723236		3.32	Polq	DNA polymerase θ	0.32
	Fmo2	Dimethyaniline monooxygenase [N-oxide-forming] 2	3.16	Mmp14	Matrix metalloproteinase-14	0.40
	Sgk1	Serine/threonine-protein kinase Sgk1	2.77	Cd93	Compliment component C1q receptor	0.45
	Rn5-8s	5.8S ribosomal RNA	2.73	Igf2	Insulin-like growth factor 2	0.47
	Ctgf	Connective tissue growth factor	2.64	Fabp7	Fatty acid-binding protein, brain	0.48
	Sult1a1	Sulfotransferase 1A1	2.56
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130	2.52
	Fst	Follistatin	2.47
	Gjb2	Gap junction β-2 protein	2.39
	Slc19a3	Thiamine transporter 2	2.24
	Zbtb16	Zinc finger and BTB domain-containing protein 16	2.12
	LOC310926		2.12
	Rn18s,Rn45s	18S ribosomal RNA	2.11
7-day ADX	Crh	Corticotropin-releasing factor	2.21	RT1-N2		0.25
	Clca1	Calcium-activated chloride channel regulator 1	2.10	Vip	Vasoactive intestinal polypeptide	0.34
				Ifit1	Interferon-induced protein with tetratricopeptide repeats 1	0.38
				Acsm5	Acyl-coenzyme A synthetase ACSM5, mitochondrial	0.39
				Sult1a1	Sulfotransferase 1A1	0.45
				Gabrd	Gamma-aminobutyric acid receptor subunit δ	0.49
Experiment 2
Acute Cort (1) 1 h	Bsx	Brain-specific homeobox protein homolog	2.60	Rn5-8s	5.8S ribosomal RNA	0.18
	Nr4a3	Nuclear receptor subfamily 4 group A member 3	2.58	Mybpc1	Myosin-binding protein C, slow-type	0.27
	Fos	Proto-oncogene c-Fos	2.03	LOC102723236		0.27
	Fosb	Protein fosB	2.03	Slc17a7	Vesicular glutamate transporter 1	0.35
				LOC310926		0.39
				Rn18s,Rn45s	18S ribosomal RNA	0.42
				Rn28s	28S ribosomal RNA	0.45
				Wnt9b	Protein Wnt-9b	0.46
				Prkcd	Protein kinase C, δ type	0.48
				RGD1560028		0.48
Acute Cort (1) 3 h				LOC102723236		0.28
				Rn5-8s	5.8S ribosomal RNA	0.29
				LOC310926		0.38
				Rn18s	18S ribosomal RNA	0.40
				Slc17a7	Vesicular glutamate transporter 1	0.42
				Rn28s	28S ribosomal RNA	0.44
				Mybpc	Myosin-binding protein C, slow-type	0.49

	Upregulated			Downregulated
	Gene Symbol	Gene Product	Fold Change	Gene Symbol	Gene Product	Fold Change
Experiment 1
12-day high Cort	Hif3a	Hypoxia-inducible factor 3-α	7.00	Crh	Corticotropin-releasing factor	0.27
	Pla2g3	Group 3 secretory phospholipase A2	4.61	Fcrl2	Fc receptor-like protein 2	0.29
	Gpd1	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	3.73	Pcdh12	Protocadherin-12	0.30
	LOC102723236		3.32	Polq	DNA polymerase θ	0.32
	Fmo2	Dimethyaniline monooxygenase [N-oxide-forming] 2	3.16	Mmp14	Matrix metalloproteinase-14	0.40
	Sgk1	Serine/threonine-protein kinase Sgk1	2.77	Cd93	Compliment component C1q receptor	0.45
	Rn5-8s	5.8S ribosomal RNA	2.73	Igf2	Insulin-like growth factor 2	0.47
	Ctgf	Connective tissue growth factor	2.64	Fabp7	Fatty acid-binding protein, brain	0.48
	Sult1a1	Sulfotransferase 1A1	2.56
	Cd163	Scavenger receptor cysteine-rich type 1 protein M130	2.52
	Fst	Follistatin	2.47
	Gjb2	Gap junction β-2 protein	2.39
	Slc19a3	Thiamine transporter 2	2.24
	Zbtb16	Zinc finger and BTB domain-containing protein 16	2.12
	LOC310926		2.12
	Rn18s,Rn45s	18S ribosomal RNA	2.11
7-day ADX	Crh	Corticotropin-releasing factor	2.21	RT1-N2		0.25
	Clca1	Calcium-activated chloride channel regulator 1	2.10	Vip	Vasoactive intestinal polypeptide	0.34
				Ifit1	Interferon-induced protein with tetratricopeptide repeats 1	0.38
				Acsm5	Acyl-coenzyme A synthetase ACSM5, mitochondrial	0.39
				Sult1a1	Sulfotransferase 1A1	0.45
				Gabrd	Gamma-aminobutyric acid receptor subunit δ	0.49
Experiment 2
Acute Cort (1) 1 h	Bsx	Brain-specific homeobox protein homolog	2.60	Rn5-8s	5.8S ribosomal RNA	0.18
	Nr4a3	Nuclear receptor subfamily 4 group A member 3	2.58	Mybpc1	Myosin-binding protein C, slow-type	0.27
	Fos	Proto-oncogene c-Fos	2.03	LOC102723236		0.27
	Fosb	Protein fosB	2.03	Slc17a7	Vesicular glutamate transporter 1	0.35
				LOC310926		0.39
				Rn18s,Rn45s	18S ribosomal RNA	0.42
				Rn28s	28S ribosomal RNA	0.45
				Wnt9b	Protein Wnt-9b	0.46
				Prkcd	Protein kinase C, δ type	0.48
				RGD1560028		0.48
Acute Cort (1) 3 h				LOC102723236		0.28
				Rn5-8s	5.8S ribosomal RNA	0.29
				LOC310926		0.38
				Rn18s	18S ribosomal RNA	0.40
				Slc17a7	Vesicular glutamate transporter 1	0.42
				Rn28s	28S ribosomal RNA	0.44
				Mybpc	Myosin-binding protein C, slow-type	0.49

Transcripts significantly upregulated (more than twofold) or significantly downregulated (<0.5-fold) are listed in this table. See text for experimental procedures.

This Feature Is Available To Subscribers Only