Median Toxin Concentration, Median Cycle Threshold Value, and Percentage With Laxative Ingestion in Clostridioides difficile Infection and Carrier Nucleic Acid Amplification Test Cohorts, Categorized by Stool Consistency
| Group . | No. . | Laxative . | Simoa Toxin A . | Simoa Toxin B . | Simoa Toxin A + B . | Cycle Threshold . |
|---|---|---|---|---|---|---|
| CDI | 122 | |||||
| Formed | 0 | NA | NA | NA | NA | NA |
| Semi-formed | 48 | 22/48 (46%) | 18.8 (0.8–2436.7) | 28.1 (3.0–7136.3) | 113.6 (6.2–9820.2) | 28.8 (25.1–33.8) |
| Liquid | 74 | 19/74 (26%) | 65.6 (1.5–3670.0) | 108.7 (4.10–5551.0) | 258.9 (8.3–11762.0) | 27.6 (23.6–31.5) |
| P = .41 | P = .46 | P = .35 | P = .09 | |||
| Carrier | 44 | |||||
| Formed | 16 | 9/16 (56%) | 10.7 (1.45–62.0) | 14.45 (7.35–42.3) | 48.8 (8.8–130.2) | 31.7 (26.9–34.3) |
| Semi-formed | 24 | 16/24 (67%) | 129.7 (28.3–951.1) | 87.6 (18.4–1626.7) | 349.6 (88.0–3054.0) | 28.3 (25.7–31.7) |
| Liquid | 4 | 3/4 (75%) | 899 (292.5–3945.5) | 253.5 (5.3–6275.5) | 1152.5 (543.3–9975.5) | 27.1 (25.0–32.1) |
| P < .01 | P = .06 | P < .01 | P = .36 |
| Group . | No. . | Laxative . | Simoa Toxin A . | Simoa Toxin B . | Simoa Toxin A + B . | Cycle Threshold . |
|---|---|---|---|---|---|---|
| CDI | 122 | |||||
| Formed | 0 | NA | NA | NA | NA | NA |
| Semi-formed | 48 | 22/48 (46%) | 18.8 (0.8–2436.7) | 28.1 (3.0–7136.3) | 113.6 (6.2–9820.2) | 28.8 (25.1–33.8) |
| Liquid | 74 | 19/74 (26%) | 65.6 (1.5–3670.0) | 108.7 (4.10–5551.0) | 258.9 (8.3–11762.0) | 27.6 (23.6–31.5) |
| P = .41 | P = .46 | P = .35 | P = .09 | |||
| Carrier | 44 | |||||
| Formed | 16 | 9/16 (56%) | 10.7 (1.45–62.0) | 14.45 (7.35–42.3) | 48.8 (8.8–130.2) | 31.7 (26.9–34.3) |
| Semi-formed | 24 | 16/24 (67%) | 129.7 (28.3–951.1) | 87.6 (18.4–1626.7) | 349.6 (88.0–3054.0) | 28.3 (25.7–31.7) |
| Liquid | 4 | 3/4 (75%) | 899 (292.5–3945.5) | 253.5 (5.3–6275.5) | 1152.5 (543.3–9975.5) | 27.1 (25.0–32.1) |
| P < .01 | P = .06 | P < .01 | P = .36 |
Laxative data refer to any dose of a relevant oral agent given within the 72 hours prior to the baseline stool collection. For toxin concentrations and cycle threshold values, data presented are median (interquartile range).
Abbreviations: CDI, Clostridioides difficile infection; NA, not applicable; Simoa, single molecule array.
Median Toxin Concentration, Median Cycle Threshold Value, and Percentage With Laxative Ingestion in Clostridioides difficile Infection and Carrier Nucleic Acid Amplification Test Cohorts, Categorized by Stool Consistency
| Group . | No. . | Laxative . | Simoa Toxin A . | Simoa Toxin B . | Simoa Toxin A + B . | Cycle Threshold . |
|---|---|---|---|---|---|---|
| CDI | 122 | |||||
| Formed | 0 | NA | NA | NA | NA | NA |
| Semi-formed | 48 | 22/48 (46%) | 18.8 (0.8–2436.7) | 28.1 (3.0–7136.3) | 113.6 (6.2–9820.2) | 28.8 (25.1–33.8) |
| Liquid | 74 | 19/74 (26%) | 65.6 (1.5–3670.0) | 108.7 (4.10–5551.0) | 258.9 (8.3–11762.0) | 27.6 (23.6–31.5) |
| P = .41 | P = .46 | P = .35 | P = .09 | |||
| Carrier | 44 | |||||
| Formed | 16 | 9/16 (56%) | 10.7 (1.45–62.0) | 14.45 (7.35–42.3) | 48.8 (8.8–130.2) | 31.7 (26.9–34.3) |
| Semi-formed | 24 | 16/24 (67%) | 129.7 (28.3–951.1) | 87.6 (18.4–1626.7) | 349.6 (88.0–3054.0) | 28.3 (25.7–31.7) |
| Liquid | 4 | 3/4 (75%) | 899 (292.5–3945.5) | 253.5 (5.3–6275.5) | 1152.5 (543.3–9975.5) | 27.1 (25.0–32.1) |
| P < .01 | P = .06 | P < .01 | P = .36 |
| Group . | No. . | Laxative . | Simoa Toxin A . | Simoa Toxin B . | Simoa Toxin A + B . | Cycle Threshold . |
|---|---|---|---|---|---|---|
| CDI | 122 | |||||
| Formed | 0 | NA | NA | NA | NA | NA |
| Semi-formed | 48 | 22/48 (46%) | 18.8 (0.8–2436.7) | 28.1 (3.0–7136.3) | 113.6 (6.2–9820.2) | 28.8 (25.1–33.8) |
| Liquid | 74 | 19/74 (26%) | 65.6 (1.5–3670.0) | 108.7 (4.10–5551.0) | 258.9 (8.3–11762.0) | 27.6 (23.6–31.5) |
| P = .41 | P = .46 | P = .35 | P = .09 | |||
| Carrier | 44 | |||||
| Formed | 16 | 9/16 (56%) | 10.7 (1.45–62.0) | 14.45 (7.35–42.3) | 48.8 (8.8–130.2) | 31.7 (26.9–34.3) |
| Semi-formed | 24 | 16/24 (67%) | 129.7 (28.3–951.1) | 87.6 (18.4–1626.7) | 349.6 (88.0–3054.0) | 28.3 (25.7–31.7) |
| Liquid | 4 | 3/4 (75%) | 899 (292.5–3945.5) | 253.5 (5.3–6275.5) | 1152.5 (543.3–9975.5) | 27.1 (25.0–32.1) |
| P < .01 | P = .06 | P < .01 | P = .36 |
Laxative data refer to any dose of a relevant oral agent given within the 72 hours prior to the baseline stool collection. For toxin concentrations and cycle threshold values, data presented are median (interquartile range).
Abbreviations: CDI, Clostridioides difficile infection; NA, not applicable; Simoa, single molecule array.
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