Cross-resistance of ciprofloxacin- and novobiocin-resistant strains to closthioamide
| Strain . | MIC (mg/L)a . | ||
|---|---|---|---|
| closthioamide . | ciprofloxacin . | novobiocin . | |
| S. aureus RN4220, WT | 0.04 | 0.2 | 0.2 |
| S. aureus RN4220, ciprofloxacin resistant (GyrA Ser84Leu) | 0.04 | 12.5 | 0.5 |
| S. aureus RN4220, novobiocin resistant (GyrB Gly86Ser) | 0.04 | 0.2 | 6.25 |
| Strain . | MIC (mg/L)a . | ||
|---|---|---|---|
| closthioamide . | ciprofloxacin . | novobiocin . | |
| S. aureus RN4220, WT | 0.04 | 0.2 | 0.2 |
| S. aureus RN4220, ciprofloxacin resistant (GyrA Ser84Leu) | 0.04 | 12.5 | 0.5 |
| S. aureus RN4220, novobiocin resistant (GyrB Gly86Ser) | 0.04 | 0.2 | 6.25 |
aAverage of two or more experiments made in duplicate.
Cross-resistance of ciprofloxacin- and novobiocin-resistant strains to closthioamide
| Strain . | MIC (mg/L)a . | ||
|---|---|---|---|
| closthioamide . | ciprofloxacin . | novobiocin . | |
| S. aureus RN4220, WT | 0.04 | 0.2 | 0.2 |
| S. aureus RN4220, ciprofloxacin resistant (GyrA Ser84Leu) | 0.04 | 12.5 | 0.5 |
| S. aureus RN4220, novobiocin resistant (GyrB Gly86Ser) | 0.04 | 0.2 | 6.25 |
| Strain . | MIC (mg/L)a . | ||
|---|---|---|---|
| closthioamide . | ciprofloxacin . | novobiocin . | |
| S. aureus RN4220, WT | 0.04 | 0.2 | 0.2 |
| S. aureus RN4220, ciprofloxacin resistant (GyrA Ser84Leu) | 0.04 | 12.5 | 0.5 |
| S. aureus RN4220, novobiocin resistant (GyrB Gly86Ser) | 0.04 | 0.2 | 6.25 |
aAverage of two or more experiments made in duplicate.
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