Table 5.
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Resistance frequency of S. aureus exposed to closthioamide and other antibiotic drugs

S. aureus RN4220aS. simulans 22aS. aureus 133b
Closthioamide1.67 × 10−105.28 × 10−9<3.2 × 10−10
Ciprofloxacin1.67 × 10−104.17 × 10−9ND
Novobiocin3.83 × 10−9NDND
MoxifloxacinNDND<3.2 × 10−10
LinezolidNDND<3.2 × 10−10
RifampicinNDND1.5 × 10−7
S. aureus RN4220aS. simulans 22aS. aureus 133b
Closthioamide1.67 × 10−105.28 × 10−9<3.2 × 10−10
Ciprofloxacin1.67 × 10−104.17 × 10−9ND
Novobiocin3.83 × 10−9NDND
MoxifloxacinNDND<3.2 × 10−10
LinezolidNDND<3.2 × 10−10
RifampicinNDND1.5 × 10−7

ND, not determined.

aTen times the microbroth dilution MIC.

bFour times the soft agar MIC.

Table 5.
Open in new tab

Resistance frequency of S. aureus exposed to closthioamide and other antibiotic drugs

S. aureus RN4220aS. simulans 22aS. aureus 133b
Closthioamide1.67 × 10−105.28 × 10−9<3.2 × 10−10
Ciprofloxacin1.67 × 10−104.17 × 10−9ND
Novobiocin3.83 × 10−9NDND
MoxifloxacinNDND<3.2 × 10−10
LinezolidNDND<3.2 × 10−10
RifampicinNDND1.5 × 10−7
S. aureus RN4220aS. simulans 22aS. aureus 133b
Closthioamide1.67 × 10−105.28 × 10−9<3.2 × 10−10
Ciprofloxacin1.67 × 10−104.17 × 10−9ND
Novobiocin3.83 × 10−9NDND
MoxifloxacinNDND<3.2 × 10−10
LinezolidNDND<3.2 × 10−10
RifampicinNDND1.5 × 10−7

ND, not determined.

aTen times the microbroth dilution MIC.

bFour times the soft agar MIC.

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