Table 1 Open in new tab Subject...

		Male (n = 79)	Female (n = 56)	t-Test
Demographic variables
Age (range)	29.4 (21–40)	4.2	28.1 (22–40)	4.4	1.72	0.088
Handedness (range)^a	96.3 (25–100)	9.9	96.0 (50–100)	10.4	0.15	0.88
Socioeconomic status (SES)^b	1.49	0.5	1.8	0.7	−2.94	0.004
Parental SES^b	2.17	0.6	2.07	0.5	−0.96	0.34
Autism-Spectrum Quotient (AQ)^c
AQ total	59.4	11.4	57.0	13.6	1.1	0.28
Prosociality	15.1	6.1	14.3	6.9	0.8	0.45
Details/Patterns	12.4	4.6	11.4	4.9	1.2	0.23
Communication	10.9	4.3	11.3	4.4	−0.5	0.6
Imagination	6.9	2.8	6.1	2.7	1.7	0.1
Global brain measures (Figure 1)
Total grey matter (cc)	761	51	674	41	10.5	<0.001
Total white matter (cc)	561	41	491	31	10.8	<0.001
Total cerebrospinal fluid (cc)	313	28	260	22	11.4	<0.001
Intracranial volume (ICV) (cc)	1635	113	1427	87	11.6	<0.001
Grey matter/ICV	0.466	0.007	0.473	0.008	−5.4	<0.001
White matter/ICV	0.343	0	0.344	0	−0.99	0.3
Cerebrospinal fluid/ICV	0.191	0.009	0.183	0.01	4.9	<0.001

Male (n = 79)

Female (n = 56)

t-Test

Variables

Mean

s.d.

Mean

s.d.

t-Value

Demographic variables

Age (range)

29.4 (21–40)

4.2

28.1 (22–40)

4.4

1.72

0.088

Handedness (range)^a

96.3 (25–100)

9.9

96.0 (50–100)

10.4

0.15

0.88

Socioeconomic status (SES)^b

1.49

0.5

1.8

0.7

−2.94

0.004

Parental SES^b

2.17

0.6

2.07

0.5

−0.96

0.34

Autism-Spectrum Quotient (AQ)^c

AQ total

59.4

11.4

57.0

13.6

1.1

0.28

Prosociality

15.1

6.1

14.3

6.9

0.8

0.45

Details/Patterns

12.4

4.6

11.4

4.9

1.2

0.23

Communication

10.9

4.3

11.3

4.4

−0.5

0.6

Imagination

6.9

2.8

6.1

2.7

1.7

0.1

Global brain measures (Figure 1)

Total grey matter (cc)

761

674

10.5

<0.001

Total white matter (cc)

561

491

10.8

<0.001

Total cerebrospinal fluid (cc)

313

260

11.4

<0.001

Intracranial volume (ICV) (cc)

1635

113

1427

11.6

<0.001

Grey matter/ICV

0.466

0.007

0.473

0.008

−5.4

<0.001

White matter/ICV

0.343

0.344

−0.99

0.3

Cerebrospinal fluid/ICV

0.191

0.009

0.183

0.01

4.9

<0.001

		Male (n = 79)	Female (n = 56)	t-Test
Demographic variables
Age (range)	29.4 (21–40)	4.2	28.1 (22–40)	4.4	1.72	0.088
Handedness (range)^a	96.3 (25–100)	9.9	96.0 (50–100)	10.4	0.15	0.88
Socioeconomic status (SES)^b	1.49	0.5	1.8	0.7	−2.94	0.004
Parental SES^b	2.17	0.6	2.07	0.5	−0.96	0.34
Autism-Spectrum Quotient (AQ)^c
AQ total	59.4	11.4	57.0	13.6	1.1	0.28
Prosociality	15.1	6.1	14.3	6.9	0.8	0.45
Details/Patterns	12.4	4.6	11.4	4.9	1.2	0.23
Communication	10.9	4.3	11.3	4.4	−0.5	0.6
Imagination	6.9	2.8	6.1	2.7	1.7	0.1
Global brain measures (Figure 1)
Total grey matter (cc)	761	51	674	41	10.5	<0.001
Total white matter (cc)	561	41	491	31	10.8	<0.001
Total cerebrospinal fluid (cc)	313	28	260	22	11.4	<0.001
Intracranial volume (ICV) (cc)	1635	113	1427	87	11.6	<0.001
Grey matter/ICV	0.466	0.007	0.473	0.008	−5.4	<0.001
White matter/ICV	0.343	0	0.344	0	−0.99	0.3
Cerebrospinal fluid/ICV	0.191	0.009	0.183	0.01	4.9	<0.001

Table 1

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Subject characteristics

	Male (n = 79)		Female (n = 56)		t-Test
Variables	Mean	s.d.	Mean	s.d.	t-Value	P
Demographic variables
Age (range)	29.4 (21–40)	4.2	28.1 (22–40)	4.4	1.72	0.088
Handedness (range)^a	96.3 (25–100)	9.9	96.0 (50–100)	10.4	0.15	0.88
Socioeconomic status (SES)^b	1.49	0.5	1.8	0.7	−2.94	0.004
Parental SES^b	2.17	0.6	2.07	0.5	−0.96	0.34
Autism-Spectrum Quotient (AQ)^c
AQ total	59.4	11.4	57.0	13.6	1.1	0.28
Prosociality	15.1	6.1	14.3	6.9	0.8	0.45
Details/Patterns	12.4	4.6	11.4	4.9	1.2	0.23
Communication	10.9	4.3	11.3	4.4	−0.5	0.6
Imagination	6.9	2.8	6.1	2.7	1.7	0.1
Global brain measures (Figure 1)
Total grey matter (cc)	761	51	674	41	10.5	<0.001
Total white matter (cc)	561	41	491	31	10.8	<0.001
Total cerebrospinal fluid (cc)	313	28	260	22	11.4	<0.001
Intracranial volume (ICV) (cc)	1635	113	1427	87	11.6	<0.001
Grey matter/ICV	0.466	0.007	0.473	0.008	−5.4	<0.001
White matter/ICV	0.343	0	0.344	0	−0.99	0.3
Cerebrospinal fluid/ICV	0.191	0.009	0.183	0.01	4.9	<0.001

	Male (n = 79)		Female (n = 56)		t-Test
Variables	Mean	s.d.	Mean	s.d.	t-Value	P
Demographic variables
Age (range)	29.4 (21–40)	4.2	28.1 (22–40)	4.4	1.72	0.088
Handedness (range)^a	96.3 (25–100)	9.9	96.0 (50–100)	10.4	0.15	0.88
Socioeconomic status (SES)^b	1.49	0.5	1.8	0.7	−2.94	0.004
Parental SES^b	2.17	0.6	2.07	0.5	−0.96	0.34
Autism-Spectrum Quotient (AQ)^c
AQ total	59.4	11.4	57.0	13.6	1.1	0.28
Prosociality	15.1	6.1	14.3	6.9	0.8	0.45
Details/Patterns	12.4	4.6	11.4	4.9	1.2	0.23
Communication	10.9	4.3	11.3	4.4	−0.5	0.6
Imagination	6.9	2.8	6.1	2.7	1.7	0.1
Global brain measures (Figure 1)
Total grey matter (cc)	761	51	674	41	10.5	<0.001
Total white matter (cc)	561	41	491	31	10.8	<0.001
Total cerebrospinal fluid (cc)	313	28	260	22	11.4	<0.001
Intracranial volume (ICV) (cc)	1635	113	1427	87	11.6	<0.001
Grey matter/ICV	0.466	0.007	0.473	0.008	−5.4	<0.001
White matter/ICV	0.343	0	0.344	0	−0.99	0.3
Cerebrospinal fluid/ICV	0.191	0.009	0.183	0.01	4.9	<0.001

^aDetermined using the Edinburgh Inventory (Oldfield, 1971): scores >0 indicate right-handedness. A score of 100 indicates strong right-handedness. ^bAssessed using the Hollingshead scale (Hollingshead, 1957). Higher scores indicate lower educational and/or occupational status. ^cHigher scores indicate strong ALTs. A four-point AQ scoring system was used, so that each item was scored on a scale ranging from 0 to 3. Thus, the total score calculated from this system can range from 0 to 150, whereas scores from the original dichotomous version range from 0 to 50.

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