Table 3

Alcohol dependence at age 20 as a predictor of reward-related BOLD response

ConditionMNI Coordinates
Cluster sizet (df = 147)
xyz
Reward Anticipation
    mPFC (BA 32)1648201423.71
    mPFC (BA 10)−1446202363.13
    mPFC (BA 24)02816863.08
    mPFC (BA 32)−64620842.79
Reward outcome
    mPFC (BA 32)2028221294.62
With past-year negative life events included as a covariate (df = 146)
Reward anticipation
    mPFC (BA 32)124822663.12
    mPFC (BAs 10, 32)−84822853.06
ConditionMNI Coordinates
Cluster sizet (df = 147)
xyz
Reward Anticipation
    mPFC (BA 32)1648201423.71
    mPFC (BA 10)−1446202363.13
    mPFC (BA 24)02816863.08
    mPFC (BA 32)−64620842.79
Reward outcome
    mPFC (BA 32)2028221294.62
With past-year negative life events included as a covariate (df = 146)
Reward anticipation
    mPFC (BA 32)124822663.12
    mPFC (BAs 10, 32)−84822853.06

Note: Alpha Sim corrected P < 0.05 for all contrasts. Results were masked for regions in which there was a significant relationship between cumulative stressful life events and reward-related BOLD response. ‘Tobacco use’, ‘neighborhood disadvantage’ and ‘caregiver education’ were included in these analyses as covariates. BA, Brodmann Area; BOLD, blood-oxygen-level-dependent; MNI, Montreal Neurological Institute.

Table 3

Alcohol dependence at age 20 as a predictor of reward-related BOLD response

ConditionMNI Coordinates
Cluster sizet (df = 147)
xyz
Reward Anticipation
    mPFC (BA 32)1648201423.71
    mPFC (BA 10)−1446202363.13
    mPFC (BA 24)02816863.08
    mPFC (BA 32)−64620842.79
Reward outcome
    mPFC (BA 32)2028221294.62
With past-year negative life events included as a covariate (df = 146)
Reward anticipation
    mPFC (BA 32)124822663.12
    mPFC (BAs 10, 32)−84822853.06
ConditionMNI Coordinates
Cluster sizet (df = 147)
xyz
Reward Anticipation
    mPFC (BA 32)1648201423.71
    mPFC (BA 10)−1446202363.13
    mPFC (BA 24)02816863.08
    mPFC (BA 32)−64620842.79
Reward outcome
    mPFC (BA 32)2028221294.62
With past-year negative life events included as a covariate (df = 146)
Reward anticipation
    mPFC (BA 32)124822663.12
    mPFC (BAs 10, 32)−84822853.06

Note: Alpha Sim corrected P < 0.05 for all contrasts. Results were masked for regions in which there was a significant relationship between cumulative stressful life events and reward-related BOLD response. ‘Tobacco use’, ‘neighborhood disadvantage’ and ‘caregiver education’ were included in these analyses as covariates. BA, Brodmann Area; BOLD, blood-oxygen-level-dependent; MNI, Montreal Neurological Institute.

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