Viral Susceptibilities of Wild-Type and S230R Viruses to Dolutegravir (DTG), Cabotegravir (CAB), Raltegravir (RAL), and Elvitegravir (EVG) in Cell-Based Assays
| Virus . | DTG . | CAB . | RAL . | EVG . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | |
| Wild type | 2 (1.63–2.45) | 1 | 0.22 (.18–.27) | 1 | 9.33 (8.71–9.99) | 1 | 0.84 (.60–1.18) | 1 | ||||
| S230R | 7.69 (6.74–8.8) | 3.85 | .02 | 0.82 (.68–1) | 3.72 | .019 | 14.18 (13.24–16.68) | 1.52 | .013 | 1.02 (.66–1.59) | 1.21 | .57 |
| Virus . | DTG . | CAB . | RAL . | EVG . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | |
| Wild type | 2 (1.63–2.45) | 1 | 0.22 (.18–.27) | 1 | 9.33 (8.71–9.99) | 1 | 0.84 (.60–1.18) | 1 | ||||
| S230R | 7.69 (6.74–8.8) | 3.85 | .02 | 0.82 (.68–1) | 3.72 | .019 | 14.18 (13.24–16.68) | 1.52 | .013 | 1.02 (.66–1.59) | 1.21 | .57 |
Each experiment was repeated 3 times in triplicate for each drug concentration.
Abbreviations: CI, confidence interval; IC50, half-maximal inhibitory concentration.
aCompared to wild-type virus, by the Student t test (OpenEpi Toolkit). Values < .05 are considered statistically significant.
Viral Susceptibilities of Wild-Type and S230R Viruses to Dolutegravir (DTG), Cabotegravir (CAB), Raltegravir (RAL), and Elvitegravir (EVG) in Cell-Based Assays
| Virus . | DTG . | CAB . | RAL . | EVG . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | |
| Wild type | 2 (1.63–2.45) | 1 | 0.22 (.18–.27) | 1 | 9.33 (8.71–9.99) | 1 | 0.84 (.60–1.18) | 1 | ||||
| S230R | 7.69 (6.74–8.8) | 3.85 | .02 | 0.82 (.68–1) | 3.72 | .019 | 14.18 (13.24–16.68) | 1.52 | .013 | 1.02 (.66–1.59) | 1.21 | .57 |
| Virus . | DTG . | CAB . | RAL . | EVG . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | Relative IC50, nM, Mean (95% CI) . | Fold Change . | Pa . | |
| Wild type | 2 (1.63–2.45) | 1 | 0.22 (.18–.27) | 1 | 9.33 (8.71–9.99) | 1 | 0.84 (.60–1.18) | 1 | ||||
| S230R | 7.69 (6.74–8.8) | 3.85 | .02 | 0.82 (.68–1) | 3.72 | .019 | 14.18 (13.24–16.68) | 1.52 | .013 | 1.02 (.66–1.59) | 1.21 | .57 |
Each experiment was repeated 3 times in triplicate for each drug concentration.
Abbreviations: CI, confidence interval; IC50, half-maximal inhibitory concentration.
aCompared to wild-type virus, by the Student t test (OpenEpi Toolkit). Values < .05 are considered statistically significant.
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