Symbol, descriptions, values, references, and sensitivity rankings for model parameters in Phase II, organized by biological category.
| CC3D Functions . | Parameter name . | Parameter value . | Reference . | Sensitivity . |
|---|---|---|---|---|
| Volume Steppable | Oocyte target volume | 22.0 pixels | [22] | Medium |
| Volume Steppable | Oocyte inverse cell compressibility | 4.0 | Estimated | Low |
| Volume Steppable | Granulosa target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Granulosa cells on inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Stromal target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Stromal inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Epithelial target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Epithelial inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Mesonephros target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Mesonephros inverse cell compressibility | 3.0 | Estimated | Low |
| Mitosis Steppable | Mitotic rate of oocytes | 0.0018333 MCS−1 | [10] | Medium |
| Mitosis Steppable | Mitotic rate of granulosa cells | 0.0001 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of stromal cells | 0.00005 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of epithelial cells | 0.000005 MCS−1 | Estimated | Medium |
| Cell Death Steppable | Death rate (apoptosis) of oocytes | 0.13 oocytes MCS−1 | [10] | High |
| Cell Death Steppable | Death rate coefficient for oocytes | 550 000 000 | Estimated | Low |
| Secretion Steppable | Secretion constant of estrogen | 0.1 μM MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | Estrogen diffusion constant | 0.99 pixels MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | SDF1 chemoattractant decay constant | 0.00001 pixels MCS−1 | Estimated | Low |
| CC3D Functions . | Parameter name . | Parameter value . | Reference . | Sensitivity . |
|---|---|---|---|---|
| Volume Steppable | Oocyte target volume | 22.0 pixels | [22] | Medium |
| Volume Steppable | Oocyte inverse cell compressibility | 4.0 | Estimated | Low |
| Volume Steppable | Granulosa target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Granulosa cells on inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Stromal target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Stromal inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Epithelial target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Epithelial inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Mesonephros target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Mesonephros inverse cell compressibility | 3.0 | Estimated | Low |
| Mitosis Steppable | Mitotic rate of oocytes | 0.0018333 MCS−1 | [10] | Medium |
| Mitosis Steppable | Mitotic rate of granulosa cells | 0.0001 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of stromal cells | 0.00005 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of epithelial cells | 0.000005 MCS−1 | Estimated | Medium |
| Cell Death Steppable | Death rate (apoptosis) of oocytes | 0.13 oocytes MCS−1 | [10] | High |
| Cell Death Steppable | Death rate coefficient for oocytes | 550 000 000 | Estimated | Low |
| Secretion Steppable | Secretion constant of estrogen | 0.1 μM MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | Estrogen diffusion constant | 0.99 pixels MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | SDF1 chemoattractant decay constant | 0.00001 pixels MCS−1 | Estimated | Low |
Rankings of parameters in Phase I and Phase II, based on evaluation of sensitivity analysis endpoints: developmental process accuracy, cell structure integrity, and germ cell abundance.
Symbol, descriptions, values, references, and sensitivity rankings for model parameters in Phase II, organized by biological category.
| CC3D Functions . | Parameter name . | Parameter value . | Reference . | Sensitivity . |
|---|---|---|---|---|
| Volume Steppable | Oocyte target volume | 22.0 pixels | [22] | Medium |
| Volume Steppable | Oocyte inverse cell compressibility | 4.0 | Estimated | Low |
| Volume Steppable | Granulosa target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Granulosa cells on inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Stromal target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Stromal inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Epithelial target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Epithelial inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Mesonephros target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Mesonephros inverse cell compressibility | 3.0 | Estimated | Low |
| Mitosis Steppable | Mitotic rate of oocytes | 0.0018333 MCS−1 | [10] | Medium |
| Mitosis Steppable | Mitotic rate of granulosa cells | 0.0001 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of stromal cells | 0.00005 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of epithelial cells | 0.000005 MCS−1 | Estimated | Medium |
| Cell Death Steppable | Death rate (apoptosis) of oocytes | 0.13 oocytes MCS−1 | [10] | High |
| Cell Death Steppable | Death rate coefficient for oocytes | 550 000 000 | Estimated | Low |
| Secretion Steppable | Secretion constant of estrogen | 0.1 μM MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | Estrogen diffusion constant | 0.99 pixels MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | SDF1 chemoattractant decay constant | 0.00001 pixels MCS−1 | Estimated | Low |
| CC3D Functions . | Parameter name . | Parameter value . | Reference . | Sensitivity . |
|---|---|---|---|---|
| Volume Steppable | Oocyte target volume | 22.0 pixels | [22] | Medium |
| Volume Steppable | Oocyte inverse cell compressibility | 4.0 | Estimated | Low |
| Volume Steppable | Granulosa target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Granulosa cells on inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Stromal target volume | 21.0 pixels | [22] | Medium |
| Volume Steppable | Stromal inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Epithelial target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Epithelial inverse cell compressibility | 3.0 | Estimated | Low |
| Volume Steppable | Mesonephros target volume | 15.0 pixels | [22] | Medium |
| Volume Steppable | Mesonephros inverse cell compressibility | 3.0 | Estimated | Low |
| Mitosis Steppable | Mitotic rate of oocytes | 0.0018333 MCS−1 | [10] | Medium |
| Mitosis Steppable | Mitotic rate of granulosa cells | 0.0001 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of stromal cells | 0.00005 MCS−1 | Estimated | Medium |
| Mitosis Steppable | Mitotic rate of epithelial cells | 0.000005 MCS−1 | Estimated | Medium |
| Cell Death Steppable | Death rate (apoptosis) of oocytes | 0.13 oocytes MCS−1 | [10] | High |
| Cell Death Steppable | Death rate coefficient for oocytes | 550 000 000 | Estimated | Low |
| Secretion Steppable | Secretion constant of estrogen | 0.1 μM MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | Estrogen diffusion constant | 0.99 pixels MCS−1 | Estimated | Low |
| Diffusion Solver Steppable | SDF1 chemoattractant decay constant | 0.00001 pixels MCS−1 | Estimated | Low |
Rankings of parameters in Phase I and Phase II, based on evaluation of sensitivity analysis endpoints: developmental process accuracy, cell structure integrity, and germ cell abundance.
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