Sensitivity and Specificity for Concurrent Cryptococcal Meningitis by Blood Cryptococcal Antigen Titer Cutoff Level in Patients With No Symptoms or Signs of Meningitis or With Headache Only (n = 62)a
| Blood CrAg Titer Cutoff . | Sensitivity (95% CI), % . | Specificity (95% CI), % . |
|---|---|---|
| >5 | 100 (89.7–100) | 21.4 (8.3–41.0) |
| >10 | 100 (89.7–100) | 32.1 (15.8–52.4) |
| >20 | 100 (89.7–100) | 46.4 (27.5–66.1) |
| >40 | 97.1 (84.7–99.9) | 57.1 (37.2–75.5) |
| >80 | 91.2 (76.3–98.1) | 71.4 (51.3–86.8) |
| >160 | 88.2 (72.5–96.7) | 82.1 (63.1–93.9) |
| >320 | 79.4 (62.1–91.3) | 85.7 (67.3–96.0) |
| >640 | 76.5 (58.8–89.3) | 89.2 (71.8–97.7) |
| >1280 | 70.6 (52.5–84.9) | 96.4 (81.7–99.9) |
| >2560 | 61.8 (43.6–77.8) | 100 (87.7–100) |
| Blood CrAg Titer Cutoff . | Sensitivity (95% CI), % . | Specificity (95% CI), % . |
|---|---|---|
| >5 | 100 (89.7–100) | 21.4 (8.3–41.0) |
| >10 | 100 (89.7–100) | 32.1 (15.8–52.4) |
| >20 | 100 (89.7–100) | 46.4 (27.5–66.1) |
| >40 | 97.1 (84.7–99.9) | 57.1 (37.2–75.5) |
| >80 | 91.2 (76.3–98.1) | 71.4 (51.3–86.8) |
| >160 | 88.2 (72.5–96.7) | 82.1 (63.1–93.9) |
| >320 | 79.4 (62.1–91.3) | 85.7 (67.3–96.0) |
| >640 | 76.5 (58.8–89.3) | 89.2 (71.8–97.7) |
| >1280 | 70.6 (52.5–84.9) | 96.4 (81.7–99.9) |
| >2560 | 61.8 (43.6–77.8) | 100 (87.7–100) |
Abbreviations: CI, confidence interval; CrAg, cryptococcal antigen.
aCrAg titers were determined using the serial dilution method.
Sensitivity and Specificity for Concurrent Cryptococcal Meningitis by Blood Cryptococcal Antigen Titer Cutoff Level in Patients With No Symptoms or Signs of Meningitis or With Headache Only (n = 62)a
| Blood CrAg Titer Cutoff . | Sensitivity (95% CI), % . | Specificity (95% CI), % . |
|---|---|---|
| >5 | 100 (89.7–100) | 21.4 (8.3–41.0) |
| >10 | 100 (89.7–100) | 32.1 (15.8–52.4) |
| >20 | 100 (89.7–100) | 46.4 (27.5–66.1) |
| >40 | 97.1 (84.7–99.9) | 57.1 (37.2–75.5) |
| >80 | 91.2 (76.3–98.1) | 71.4 (51.3–86.8) |
| >160 | 88.2 (72.5–96.7) | 82.1 (63.1–93.9) |
| >320 | 79.4 (62.1–91.3) | 85.7 (67.3–96.0) |
| >640 | 76.5 (58.8–89.3) | 89.2 (71.8–97.7) |
| >1280 | 70.6 (52.5–84.9) | 96.4 (81.7–99.9) |
| >2560 | 61.8 (43.6–77.8) | 100 (87.7–100) |
| Blood CrAg Titer Cutoff . | Sensitivity (95% CI), % . | Specificity (95% CI), % . |
|---|---|---|
| >5 | 100 (89.7–100) | 21.4 (8.3–41.0) |
| >10 | 100 (89.7–100) | 32.1 (15.8–52.4) |
| >20 | 100 (89.7–100) | 46.4 (27.5–66.1) |
| >40 | 97.1 (84.7–99.9) | 57.1 (37.2–75.5) |
| >80 | 91.2 (76.3–98.1) | 71.4 (51.3–86.8) |
| >160 | 88.2 (72.5–96.7) | 82.1 (63.1–93.9) |
| >320 | 79.4 (62.1–91.3) | 85.7 (67.3–96.0) |
| >640 | 76.5 (58.8–89.3) | 89.2 (71.8–97.7) |
| >1280 | 70.6 (52.5–84.9) | 96.4 (81.7–99.9) |
| >2560 | 61.8 (43.6–77.8) | 100 (87.7–100) |
Abbreviations: CI, confidence interval; CrAg, cryptococcal antigen.
aCrAg titers were determined using the serial dilution method.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
