When significant DEG lists before (3591 transcripts) and after (1211) deconvolution analysis were compared, 946 transcripts came out significant in both approaches (Fig. 6, Supplementary Tables SIII and SIV) and therefore were considered as genes with the true expression change in MSE compared to ESE. There were 2645 transcripts, which are almost 74% from all DE transcripts identified without deconvolution, not considered significantly differentially expressed after adjustment for tissue cellular composition (Fig. 6; Supplementary Table SIII). Of these, the genes with the highest expression change between MSE and ESE in whole tissue (Log₂FC > 3), yet not differentially expressed after deconvolution, are presented in the Table I. Moreover, 265 transcripts came out significant only after deconvolution was applied (Fig. 6; Supplementary Table SIV).