Table 2.

Biochemical and Immunologic Assessments for Case 2

ParameterBaselineaPresentationNormal Range
Blood glucose10283460–125 mg/dL
HbA1c5.4<6.5%
Sodium138130135–145 mmol/L
Potassium4.15.43.5–5 mmol/L
Chloride1079598–107 mmol/L
HCO3234.822–26 mEq/L
Creatinine0.931.230.6–1.2 mg/dL
BUN19357–20 mg/dL
Arterial pH7.087.35–7.45
Beta-hydroxybutyrate>8<0.5 mmol/L
Urine ketones8+Negative
GADA719<20 DK units
IAA0<0.01
IA-2A0<5 DK units
ZnT8A0<0.02
TG IgA0<0.05
21(OH)0.012<0.15
ParameterBaselineaPresentationNormal Range
Blood glucose10283460–125 mg/dL
HbA1c5.4<6.5%
Sodium138130135–145 mmol/L
Potassium4.15.43.5–5 mmol/L
Chloride1079598–107 mmol/L
HCO3234.822–26 mEq/L
Creatinine0.931.230.6–1.2 mg/dL
BUN19357–20 mg/dL
Arterial pH7.087.35–7.45
Beta-hydroxybutyrate>8<0.5 mmol/L
Urine ketones8+Negative
GADA719<20 DK units
IAA0<0.01
IA-2A0<5 DK units
ZnT8A0<0.02
TG IgA0<0.05
21(OH)0.012<0.15

21(OH), 21-hydroxylase antibody; BUN, blood urea nitrogen; GADA, glutamic acid decarboxylase antibody; IA-2A, islet antigen 2 antibody; IAA, insulin autoantibody; ZnT8A, zinc transporter 8 antibody; TG IgA, tissue transglutaminase IgA antibody.

a

Laboratory values are 1 wk before the first dose of PD-1 inhibitor therapy.

Table 2.

Biochemical and Immunologic Assessments for Case 2

ParameterBaselineaPresentationNormal Range
Blood glucose10283460–125 mg/dL
HbA1c5.4<6.5%
Sodium138130135–145 mmol/L
Potassium4.15.43.5–5 mmol/L
Chloride1079598–107 mmol/L
HCO3234.822–26 mEq/L
Creatinine0.931.230.6–1.2 mg/dL
BUN19357–20 mg/dL
Arterial pH7.087.35–7.45
Beta-hydroxybutyrate>8<0.5 mmol/L
Urine ketones8+Negative
GADA719<20 DK units
IAA0<0.01
IA-2A0<5 DK units
ZnT8A0<0.02
TG IgA0<0.05
21(OH)0.012<0.15
ParameterBaselineaPresentationNormal Range
Blood glucose10283460–125 mg/dL
HbA1c5.4<6.5%
Sodium138130135–145 mmol/L
Potassium4.15.43.5–5 mmol/L
Chloride1079598–107 mmol/L
HCO3234.822–26 mEq/L
Creatinine0.931.230.6–1.2 mg/dL
BUN19357–20 mg/dL
Arterial pH7.087.35–7.45
Beta-hydroxybutyrate>8<0.5 mmol/L
Urine ketones8+Negative
GADA719<20 DK units
IAA0<0.01
IA-2A0<5 DK units
ZnT8A0<0.02
TG IgA0<0.05
21(OH)0.012<0.15

21(OH), 21-hydroxylase antibody; BUN, blood urea nitrogen; GADA, glutamic acid decarboxylase antibody; IA-2A, islet antigen 2 antibody; IAA, insulin autoantibody; ZnT8A, zinc transporter 8 antibody; TG IgA, tissue transglutaminase IgA antibody.

a

Laboratory values are 1 wk before the first dose of PD-1 inhibitor therapy.

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