| Parameter . | Baseline With Full Immunosuppressiona . | Baseline After Withdrawal of Immunosuppression Except Steroidsb . | Presentation With Acute Renal Failure . | Normal Range . |
|---|---|---|---|---|
| Creatinine | 1.1 | 1.3 | 9.1 | 0.6–1.2 mg/dL |
| eGFR | 77 | 63 | 6 | 90–120 mL/min/1.73 m2 |
| BUN | 17 | 22 | 86 | 7–20 mg/dL |
| Potassium | 4.4 | 4.5 | 5.7 | 3.5–5 mmol/L |
| TSH | 3.8 | — | 62.7 | 0.4–4.2 mIU/L |
| HbA1c | 8.8 | — | 9.0 | <6.5% |
| GADA | — | — | 18 | <20 DK units |
| IAA | — | — | 0 | <0.01 |
| IA-2A | — | — | 0 | <5 DK units |
| ZnT8A | — | — | 0 | <0.02 |
| TG IgA | — | — | 0.008 | <0.05 |
| 21(OH) | — | — | 0.005 | <0.15 |
| Parameter . | Baseline With Full Immunosuppressiona . | Baseline After Withdrawal of Immunosuppression Except Steroidsb . | Presentation With Acute Renal Failure . | Normal Range . |
|---|---|---|---|---|
| Creatinine | 1.1 | 1.3 | 9.1 | 0.6–1.2 mg/dL |
| eGFR | 77 | 63 | 6 | 90–120 mL/min/1.73 m2 |
| BUN | 17 | 22 | 86 | 7–20 mg/dL |
| Potassium | 4.4 | 4.5 | 5.7 | 3.5–5 mmol/L |
| TSH | 3.8 | — | 62.7 | 0.4–4.2 mIU/L |
| HbA1c | 8.8 | — | 9.0 | <6.5% |
| GADA | — | — | 18 | <20 DK units |
| IAA | — | — | 0 | <0.01 |
| IA-2A | — | — | 0 | <5 DK units |
| ZnT8A | — | — | 0 | <0.02 |
| TG IgA | — | — | 0.008 | <0.05 |
| 21(OH) | — | — | 0.005 | <0.15 |
Levels of autoantibodies are expressed as DK units for GADA and IA-2A or an index for the other autoantibodies.
Abbreviations: 21(OH), 21-hydroxylase antibody; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; GADA, glutamic acid decarboxylase antibody; IA-2A, islet antigen 2 antibody; IAA, insulin autoantibody; ZnT8A, zinc transporter 8 antibody; TG IgA, tissue transglutaminase IgA antibody.
Laboratory values 2 wks before the first dose of PD-1 inhibitor therapy.
Laboratory values 1 wk before the first dose of PD-1 inhibitor therapy.
| Parameter . | Baseline With Full Immunosuppressiona . | Baseline After Withdrawal of Immunosuppression Except Steroidsb . | Presentation With Acute Renal Failure . | Normal Range . |
|---|---|---|---|---|
| Creatinine | 1.1 | 1.3 | 9.1 | 0.6–1.2 mg/dL |
| eGFR | 77 | 63 | 6 | 90–120 mL/min/1.73 m2 |
| BUN | 17 | 22 | 86 | 7–20 mg/dL |
| Potassium | 4.4 | 4.5 | 5.7 | 3.5–5 mmol/L |
| TSH | 3.8 | — | 62.7 | 0.4–4.2 mIU/L |
| HbA1c | 8.8 | — | 9.0 | <6.5% |
| GADA | — | — | 18 | <20 DK units |
| IAA | — | — | 0 | <0.01 |
| IA-2A | — | — | 0 | <5 DK units |
| ZnT8A | — | — | 0 | <0.02 |
| TG IgA | — | — | 0.008 | <0.05 |
| 21(OH) | — | — | 0.005 | <0.15 |
| Parameter . | Baseline With Full Immunosuppressiona . | Baseline After Withdrawal of Immunosuppression Except Steroidsb . | Presentation With Acute Renal Failure . | Normal Range . |
|---|---|---|---|---|
| Creatinine | 1.1 | 1.3 | 9.1 | 0.6–1.2 mg/dL |
| eGFR | 77 | 63 | 6 | 90–120 mL/min/1.73 m2 |
| BUN | 17 | 22 | 86 | 7–20 mg/dL |
| Potassium | 4.4 | 4.5 | 5.7 | 3.5–5 mmol/L |
| TSH | 3.8 | — | 62.7 | 0.4–4.2 mIU/L |
| HbA1c | 8.8 | — | 9.0 | <6.5% |
| GADA | — | — | 18 | <20 DK units |
| IAA | — | — | 0 | <0.01 |
| IA-2A | — | — | 0 | <5 DK units |
| ZnT8A | — | — | 0 | <0.02 |
| TG IgA | — | — | 0.008 | <0.05 |
| 21(OH) | — | — | 0.005 | <0.15 |
Levels of autoantibodies are expressed as DK units for GADA and IA-2A or an index for the other autoantibodies.
Abbreviations: 21(OH), 21-hydroxylase antibody; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; GADA, glutamic acid decarboxylase antibody; IA-2A, islet antigen 2 antibody; IAA, insulin autoantibody; ZnT8A, zinc transporter 8 antibody; TG IgA, tissue transglutaminase IgA antibody.
Laboratory values 2 wks before the first dose of PD-1 inhibitor therapy.
Laboratory values 1 wk before the first dose of PD-1 inhibitor therapy.
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