Table 1.

Characteristics of 9 Heart Transplant Recipients and 11 Patients in the Genotyping Control Group Infected with Pneumocystis jiroveciia

Patient CodeAge ySexType of Pulmonary SpecimenDate of Pulmonary Specimen Retrieval (in 2015)Underlying ConditionClinical Presentation of Pneumocystis InfectionProphylaxisCYB Alleleb
HTRs
 HTR144MBAL17 MarchHeart and renal transplantation; HIV infectionPCPAtovaquoneCYB2 (C350T)c
 HTR235FInduced sputum12 MayHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR368MBAL15 JulyHeart transplantationPCPNoneCYB2 (C350T)c
 HTR464MBAL28 JulyHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR550MBAL6 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR669FBAL24 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR768FNasopharyngeal swab31 AugustHeart transplantationColonizationNoneCYB2 (C350T)c
 HTR838MBAL2 SeptemberHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR945MNasopharyngeal swab2 SeptemberHeart transplantationColonizationAtovaquoneCYB2 (C350T)c
Genotyping control patients
 C169FInduced sputum8 JanuaryCorticosteroid treatmentColonizationNoneCYB1
 C253MBAL22 JanuaryLiver transplantationPCPNoneCYB2
 C353MBAL26 JanuaryHIV infectionPCPNoneCYB1
 C465MBAL5 FebruaryCorticosteroid treatmentPCPNoneCYB1
 C570FBAL24 FebruaryCorticosteroid treatmentPCPNoneMixed infectiond
 C644FInduced sputum9 MarchHIV infectionPCPNoneCYB1
 C768MBAL21 MarchLiver transplantationPCPNoneCYB2
 C866MBAL31 MarchCancerPCPNoneMixed infectione
 C964MBAL13 AprilCancerPCPNoneMixed infectionf
 C1072FSputum5 MayCancerPCPCotrimoxazoleCYB6
 C1156MBAL7 MayCorticosteroid treatmentColonizationNoneMixed infectione
Patient CodeAge ySexType of Pulmonary SpecimenDate of Pulmonary Specimen Retrieval (in 2015)Underlying ConditionClinical Presentation of Pneumocystis InfectionProphylaxisCYB Alleleb
HTRs
 HTR144MBAL17 MarchHeart and renal transplantation; HIV infectionPCPAtovaquoneCYB2 (C350T)c
 HTR235FInduced sputum12 MayHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR368MBAL15 JulyHeart transplantationPCPNoneCYB2 (C350T)c
 HTR464MBAL28 JulyHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR550MBAL6 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR669FBAL24 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR768FNasopharyngeal swab31 AugustHeart transplantationColonizationNoneCYB2 (C350T)c
 HTR838MBAL2 SeptemberHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR945MNasopharyngeal swab2 SeptemberHeart transplantationColonizationAtovaquoneCYB2 (C350T)c
Genotyping control patients
 C169FInduced sputum8 JanuaryCorticosteroid treatmentColonizationNoneCYB1
 C253MBAL22 JanuaryLiver transplantationPCPNoneCYB2
 C353MBAL26 JanuaryHIV infectionPCPNoneCYB1
 C465MBAL5 FebruaryCorticosteroid treatmentPCPNoneCYB1
 C570FBAL24 FebruaryCorticosteroid treatmentPCPNoneMixed infectiond
 C644FInduced sputum9 MarchHIV infectionPCPNoneCYB1
 C768MBAL21 MarchLiver transplantationPCPNoneCYB2
 C866MBAL31 MarchCancerPCPNoneMixed infectione
 C964MBAL13 AprilCancerPCPNoneMixed infectionf
 C1072FSputum5 MayCancerPCPCotrimoxazoleCYB6
 C1156MBAL7 MayCorticosteroid treatmentColonizationNoneMixed infectione

Abbreviations: BAL, bronchoalveolar lavage; CYB, cytochrome b (cyt b) gene; HIV, human immunodeficiency virus; HTRs, heart transplant recipients; PCP, Pneumocystis pneumonia.

aPatients were monitored at Bichat–Claude Bernard hospital, Paris, France, and P. jirovecii isolates were examined at the CYB gene.

bCytochrome b alleles were named using nomenclature described elsewhere by Esteves et al [15] and Maitte et al [16].

cCYB2 (C350T) allele corresponds to allele CYB2, as described elsewhere by Esteves et al [15], but it harbors a previously undescribed mutation on position 350 (C350T).

dPatient C5 presented with a mixed infection related to association of the alleles CYB1 and CYB7.

ePatients C8 and C11 presented with mixed infections. The alleles were not identified because polymorphisms were observed at 2 nucleotide positions; that is, 2 peaks were observed on chromatograms at 2 different positions.

fPatient C9 presented with a mixed infection related to association of the alleles CYB1 and CYB2.

Table 1.

Characteristics of 9 Heart Transplant Recipients and 11 Patients in the Genotyping Control Group Infected with Pneumocystis jiroveciia

Patient CodeAge ySexType of Pulmonary SpecimenDate of Pulmonary Specimen Retrieval (in 2015)Underlying ConditionClinical Presentation of Pneumocystis InfectionProphylaxisCYB Alleleb
HTRs
 HTR144MBAL17 MarchHeart and renal transplantation; HIV infectionPCPAtovaquoneCYB2 (C350T)c
 HTR235FInduced sputum12 MayHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR368MBAL15 JulyHeart transplantationPCPNoneCYB2 (C350T)c
 HTR464MBAL28 JulyHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR550MBAL6 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR669FBAL24 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR768FNasopharyngeal swab31 AugustHeart transplantationColonizationNoneCYB2 (C350T)c
 HTR838MBAL2 SeptemberHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR945MNasopharyngeal swab2 SeptemberHeart transplantationColonizationAtovaquoneCYB2 (C350T)c
Genotyping control patients
 C169FInduced sputum8 JanuaryCorticosteroid treatmentColonizationNoneCYB1
 C253MBAL22 JanuaryLiver transplantationPCPNoneCYB2
 C353MBAL26 JanuaryHIV infectionPCPNoneCYB1
 C465MBAL5 FebruaryCorticosteroid treatmentPCPNoneCYB1
 C570FBAL24 FebruaryCorticosteroid treatmentPCPNoneMixed infectiond
 C644FInduced sputum9 MarchHIV infectionPCPNoneCYB1
 C768MBAL21 MarchLiver transplantationPCPNoneCYB2
 C866MBAL31 MarchCancerPCPNoneMixed infectione
 C964MBAL13 AprilCancerPCPNoneMixed infectionf
 C1072FSputum5 MayCancerPCPCotrimoxazoleCYB6
 C1156MBAL7 MayCorticosteroid treatmentColonizationNoneMixed infectione
Patient CodeAge ySexType of Pulmonary SpecimenDate of Pulmonary Specimen Retrieval (in 2015)Underlying ConditionClinical Presentation of Pneumocystis InfectionProphylaxisCYB Alleleb
HTRs
 HTR144MBAL17 MarchHeart and renal transplantation; HIV infectionPCPAtovaquoneCYB2 (C350T)c
 HTR235FInduced sputum12 MayHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR368MBAL15 JulyHeart transplantationPCPNoneCYB2 (C350T)c
 HTR464MBAL28 JulyHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR550MBAL6 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR669FBAL24 AugustHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR768FNasopharyngeal swab31 AugustHeart transplantationColonizationNoneCYB2 (C350T)c
 HTR838MBAL2 SeptemberHeart transplantationPCPAtovaquoneCYB2 (C350T)c
 HTR945MNasopharyngeal swab2 SeptemberHeart transplantationColonizationAtovaquoneCYB2 (C350T)c
Genotyping control patients
 C169FInduced sputum8 JanuaryCorticosteroid treatmentColonizationNoneCYB1
 C253MBAL22 JanuaryLiver transplantationPCPNoneCYB2
 C353MBAL26 JanuaryHIV infectionPCPNoneCYB1
 C465MBAL5 FebruaryCorticosteroid treatmentPCPNoneCYB1
 C570FBAL24 FebruaryCorticosteroid treatmentPCPNoneMixed infectiond
 C644FInduced sputum9 MarchHIV infectionPCPNoneCYB1
 C768MBAL21 MarchLiver transplantationPCPNoneCYB2
 C866MBAL31 MarchCancerPCPNoneMixed infectione
 C964MBAL13 AprilCancerPCPNoneMixed infectionf
 C1072FSputum5 MayCancerPCPCotrimoxazoleCYB6
 C1156MBAL7 MayCorticosteroid treatmentColonizationNoneMixed infectione

Abbreviations: BAL, bronchoalveolar lavage; CYB, cytochrome b (cyt b) gene; HIV, human immunodeficiency virus; HTRs, heart transplant recipients; PCP, Pneumocystis pneumonia.

aPatients were monitored at Bichat–Claude Bernard hospital, Paris, France, and P. jirovecii isolates were examined at the CYB gene.

bCytochrome b alleles were named using nomenclature described elsewhere by Esteves et al [15] and Maitte et al [16].

cCYB2 (C350T) allele corresponds to allele CYB2, as described elsewhere by Esteves et al [15], but it harbors a previously undescribed mutation on position 350 (C350T).

dPatient C5 presented with a mixed infection related to association of the alleles CYB1 and CYB7.

ePatients C8 and C11 presented with mixed infections. The alleles were not identified because polymorphisms were observed at 2 nucleotide positions; that is, 2 peaks were observed on chromatograms at 2 different positions.

fPatient C9 presented with a mixed infection related to association of the alleles CYB1 and CYB2.

Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close