Characteristics of 47 Patients With Clinical Deterioration Following Lumbar Puncture
| Characteristic . | Patients With Deterioration (n = 47) . |
|---|---|
| Age, y, median (IQR) | 63 (49–68) |
| Male sex | 21/47 (45) |
| New-onset seizures | 7/47 (15) |
| Score on GCS, median (IQR) | 9 (6–11) |
| GCS score <10 | 29/47 (62) |
| Streptococcus pneumoniae as causative organism | 37/47 (79) |
| Guideline indication for CT prior to LPa | 38/47 (81) |
| Empiric treatment started prior to cranial CT | 11/38 (28) |
| Local report of cranial CT | |
| Normal | 17/43 (40) |
| Generalized edema | 13/43 (30) |
| Hydrocephalus | 2/43 (5) |
| Generalized edema and hydrocephalus | 4/43 (9) |
| Intracranial air | 2/43 (5) |
| Other (metastasis, old vascular abnormalities, focal edema) | 5/43 (12) |
| Characteristic . | Patients With Deterioration (n = 47) . |
|---|---|
| Age, y, median (IQR) | 63 (49–68) |
| Male sex | 21/47 (45) |
| New-onset seizures | 7/47 (15) |
| Score on GCS, median (IQR) | 9 (6–11) |
| GCS score <10 | 29/47 (62) |
| Streptococcus pneumoniae as causative organism | 37/47 (79) |
| Guideline indication for CT prior to LPa | 38/47 (81) |
| Empiric treatment started prior to cranial CT | 11/38 (28) |
| Local report of cranial CT | |
| Normal | 17/43 (40) |
| Generalized edema | 13/43 (30) |
| Hydrocephalus | 2/43 (5) |
| Generalized edema and hydrocephalus | 4/43 (9) |
| Intracranial air | 2/43 (5) |
| Other (metastasis, old vascular abnormalities, focal edema) | 5/43 (12) |
Data are presented as no./ No. (%) with data available unless otherwise indicated.
Abbreviations: CT, computed tomography; GCS, Glasgow Coma Scale score; IQR, interquartile range; LP, lumbar puncture.
aNew-onset seizures, papilledema, severe immunocompromised state, focal neurologic deficits (excluding cranial nerve palsy), or GCS score <10 [20].
bLowest GCS score after clinical deterioration was available in 46 of 47 patients (98%).
Characteristics of 47 Patients With Clinical Deterioration Following Lumbar Puncture
| Characteristic . | Patients With Deterioration (n = 47) . |
|---|---|
| Age, y, median (IQR) | 63 (49–68) |
| Male sex | 21/47 (45) |
| New-onset seizures | 7/47 (15) |
| Score on GCS, median (IQR) | 9 (6–11) |
| GCS score <10 | 29/47 (62) |
| Streptococcus pneumoniae as causative organism | 37/47 (79) |
| Guideline indication for CT prior to LPa | 38/47 (81) |
| Empiric treatment started prior to cranial CT | 11/38 (28) |
| Local report of cranial CT | |
| Normal | 17/43 (40) |
| Generalized edema | 13/43 (30) |
| Hydrocephalus | 2/43 (5) |
| Generalized edema and hydrocephalus | 4/43 (9) |
| Intracranial air | 2/43 (5) |
| Other (metastasis, old vascular abnormalities, focal edema) | 5/43 (12) |
| Characteristic . | Patients With Deterioration (n = 47) . |
|---|---|
| Age, y, median (IQR) | 63 (49–68) |
| Male sex | 21/47 (45) |
| New-onset seizures | 7/47 (15) |
| Score on GCS, median (IQR) | 9 (6–11) |
| GCS score <10 | 29/47 (62) |
| Streptococcus pneumoniae as causative organism | 37/47 (79) |
| Guideline indication for CT prior to LPa | 38/47 (81) |
| Empiric treatment started prior to cranial CT | 11/38 (28) |
| Local report of cranial CT | |
| Normal | 17/43 (40) |
| Generalized edema | 13/43 (30) |
| Hydrocephalus | 2/43 (5) |
| Generalized edema and hydrocephalus | 4/43 (9) |
| Intracranial air | 2/43 (5) |
| Other (metastasis, old vascular abnormalities, focal edema) | 5/43 (12) |
Data are presented as no./ No. (%) with data available unless otherwise indicated.
Abbreviations: CT, computed tomography; GCS, Glasgow Coma Scale score; IQR, interquartile range; LP, lumbar puncture.
aNew-onset seizures, papilledema, severe immunocompromised state, focal neurologic deficits (excluding cranial nerve palsy), or GCS score <10 [20].
bLowest GCS score after clinical deterioration was available in 46 of 47 patients (98%).
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