The family history of MGPT TP53 women...

The family history of MGPT TP53+ women was less likely than that of SGT TP53+ women to include a relative with an LFS core cancer (P = .003); the difference was not statistically significant for men (P = .75) (Table 6). Age at first cancer was also stratified by family history of LFS cancer in a first- or second-degree relative (female probands P < .001, male probands P = .005) (Supplementary Figure 1, available online) or by family history of breast cancer diagnosed at age 35 years or younger in a first- or second-degree relative (both P < .001) (Supplementary Figure 2, available online). SGT TP53+ subjects had earlier age at first cancer than MGPT TP53+ subjects for each sex in each figure.

Family history variables*	SGT	MGPT	P†
Women
No. of TP53 positives	99	82
% with family female breast cancer (any age)	50.5	53.7	.77
% with family female breast cancer ≤35y	22.2	15.9	.34
% with family LFS core cancer‡	42.2	22.1	.003
Men
No. of TP53 positives	27	14
% with family female breast cancer (any age)	55.6	64.3	.74
% with family female breast cancer ≤35 y	29.6	21.4	.72
% with family LFS core cancer‡	44.4	35.7	.75

Family history variables*	SGT	MGPT	P†
Women
No. of TP53 positives	99	82
% with family female breast cancer (any age)	50.5	53.7	.77
% with family female breast cancer ≤35y	22.2	15.9	.34
% with family LFS core cancer‡	42.2	22.1	.003
Men
No. of TP53 positives	27	14
% with family female breast cancer (any age)	55.6	64.3	.74
% with family female breast cancer ≤35 y	29.6	21.4	.72
% with family LFS core cancer‡	44.4	35.7	.75

Table 6.

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TP53+ subjects’ family history characteristics

Family history variables*	SGT	MGPT	P†
Women
No. of TP53 positives	99	82
% with family female breast cancer (any age)	50.5	53.7	.77
% with family female breast cancer ≤35y	22.2	15.9	.34
% with family LFS core cancer‡	42.2	22.1	.003
Men
No. of TP53 positives	27	14
% with family female breast cancer (any age)	55.6	64.3	.74
% with family female breast cancer ≤35 y	29.6	21.4	.72
% with family LFS core cancer‡	44.4	35.7	.75

Family history variables*	SGT	MGPT	P†
Women
No. of TP53 positives	99	82
% with family female breast cancer (any age)	50.5	53.7	.77
% with family female breast cancer ≤35y	22.2	15.9	.34
% with family LFS core cancer‡	42.2	22.1	.003
Men
No. of TP53 positives	27	14
% with family female breast cancer (any age)	55.6	64.3	.74
% with family female breast cancer ≤35 y	29.6	21.4	.72
% with family LFS core cancer‡	44.4	35.7	.75

Proband cancer history excluded. LFS = Li-Fraumeni syndrome; MGPT = multigene panel test; SGT = single-gene test.

†

All tests were two-sided Fisher exact tests.

‡

LFS cancer excluding breast cancer and leukemia, but including sarcoma, brain, adrenocortical carcinoma, and choroid plexus carcinoma.

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