Table 2. Open in new tab Vibriocidal...

Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	No. (%) Who Seroconverted After:	Geometric Mean Fold Rise After:
Bivalent oral cholera vaccine
Kanungo, 2009	37 (18+ years)	India	186	14 days	24 (65)	17 (46)	9	5
	39 (1–17 years)		37	14 days	34 (87)	32 (82)	47	24
Saha, 2011	53 (18–45 years)	Bangladesh	55	14 days	(60)^f	(57)^c	9 ^c	NA^b
	55 (2–4 years)		55		(78)^f	(76) ^c	12 ^c	NA^b
	54 (12–24 months)		8		(52)^f	(72) ^c	7 ^c	NA^b
Charles, 2014	23 adults	Haiti	11	14 days	(77) ^f	(91) ^c	19 ^c	19 ^c
	45 (6 to 17 years)		27		(69) ^f	(74) ^c	11 ^c	10 ^c
	42 (1–4 years)		16		(64) ^f	(73) ^c	9 ^c	10 ^c
Kanungo, 2015	96 (15+ years)	India	171	14 days	67 (70)	58 (60)	7	5
	90 (6–14 years)		50	14 days	(88)	(79)	26	14
	91 (15+ years)		238	14 days	(57)	(51)	5	4
	93 (6–14 years)		81	14 days	(85)	(82)	33	16
Kanungo, 2015	86 adults (≥18 years)	India	191	14 days	59 (69)	47 (55)	7	5
			144	28 days	55 (66)	49 (58)	9	5
	84 children (1–17 years)		47	14 days	72 (86)	67 (80)	30	18
			89	28 days	73 (89)	63 (77)	21	11
Aloysia, 2015	112 (15+ years)	Philippines	36	14 days	(83)	(78)	25	18
	112 (5–14 years)		3		(88)	(87)	58	49
	112 (1–4 years)		1		(88)	(89)	67	67
Desai, 2015	54 (18+ years)	Ethiopia	16	14 days	37 (70)	43 (81)	11	15
	53 (1–17 years)		6		39 (74)	41 (77)	13	13
Ivers, 2015	25 HIV+ adults	Haiti	11	14 days	(65)^c	(74) ^c	7 ^c	7 ^c
	25 HIV– adults		11		(82) ^f	(91) ^c	17 ^c	20^c
Baik, 2014	20 adults	Korea	4	14 days	18 (90)	19 (95)	74	94
Baik, 2015	Shanchol 376 adults 235 (1–17 years)	Philippines	36	14 days	315 (84)	287 (76)	30	21
			12		198 (84)	209 (89)	51	52
	Euvichol 366 adults 236 (1–17 years)		36		317(84)	308 (82)	32	22
			12		198 (86)	202 (87)	55	51
Saha, 2016	143 adults^d	Bangladesh	99	14 days	109 (76)^c	105 (73)^c	11^c	9^c
Iyer, 2016	37 (1–5 years) 67 (6–17 years) 101 adults (18–59 years)	South Sudan	11	~21 days	9 (75)	12 (80)	11	9
			30		8 (53)	12 (38)	2	3
			22		28 (61)	31 (57)	8	7
Matias, 2016	22 adults	Haiti	29	14 days	16 (73)^c	17 (81)^c	9^c	9^c

Study

Number of Participants
(Age Group)

Study Site

Baseline
Geometric Mean Titers

Interval Between Doses, days

No. (%) Who Seroconverted After:

Geometric Mean Fold Rise After:

1st Dose^a

2nd Dose^a

1st Dose^a

2nd Dose^a

Bivalent oral cholera vaccine

Kanungo, 2009

37 (18+ years)

India

186

14 days

24 (65)

17 (46)

39 (1–17 years)

14 days

34 (87)

32 (82)

Saha, 2011

53 (18–45 years)

Bangladesh

14 days

(60)^f

(57)^c

9 ^c

NA^b

55 (2–4 years)

(78)^f

(76) ^c

12 ^c

NA^b

54 (12–24 months)

(52)^f

(72) ^c

7 ^c

NA^b

Charles, 2014

23 adults

Haiti

14 days

(77) ^f

(91) ^c

19 ^c

45 (6 to 17 years)

(69) ^f

(74) ^c

11 ^c

10 ^c

42 (1–4 years)

(64) ^f

(73) ^c

9 ^c

10 ^c

Kanungo, 2015

96 (15+ years)

India

171

14 days

67 (70)

58 (60)

90 (6–14 years)

14 days

(88)

(79)

91 (15+ years)

238

14 days

(57)

(51)

93 (6–14 years)

14 days

(85)

(82)

Kanungo, 2015

86 adults (≥18 years)

India

191

14 days

59 (69)

47 (55)

144

28 days

55 (66)

49 (58)

84 children (1–17 years)

14 days

72 (86)

67 (80)

28 days

73 (89)

63 (77)

Aloysia, 2015

112 (15+ years)

Philippines

14 days

(83)

(78)

112 (5–14 years)

(88)

(87)

112 (1–4 years)

(88)

(89)

Desai, 2015

54 (18+ years)

Ethiopia

14 days

37 (70)

43 (81)

53 (1–17 years)

39 (74)

41 (77)

Ivers, 2015

25 HIV+ adults

Haiti

14 days

(65)^c

(74) ^c

7 ^c

25 HIV– adults

(82) ^f

(91) ^c

17 ^c

20^c

Baik, 2014

20 adults

Korea

14 days

18 (90)

19 (95)

Baik, 2015

Shanchol
376 adults
235 (1–17 years)

Philippines

14 days

315 (84)

287 (76)

198 (84)

209 (89)

Euvichol
366 adults
236 (1–17 years)

317(84)

308 (82)

198 (86)

202 (87)

Saha, 2016

143 adults^d

Bangladesh

14 days

109 (76)^c

105 (73)^c

11^c

9^c

Iyer, 2016

37 (1–5 years)
67 (6–17 years)
101 adults (18–59 years)

South Sudan

~21 days

9 (75)

12 (80)

8 (53)

12 (38)

28 (61)

31 (57)

Matias, 2016

22 adults

Haiti

14 days

16 (73)^c

17 (81)^c

9^c

Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	No. (%) Who Seroconverted After:	Geometric Mean Fold Rise After:
Bivalent oral cholera vaccine
Kanungo, 2009	37 (18+ years)	India	186	14 days	24 (65)	17 (46)	9	5
	39 (1–17 years)		37	14 days	34 (87)	32 (82)	47	24
Saha, 2011	53 (18–45 years)	Bangladesh	55	14 days	(60)^f	(57)^c	9 ^c	NA^b
	55 (2–4 years)		55		(78)^f	(76) ^c	12 ^c	NA^b
	54 (12–24 months)		8		(52)^f	(72) ^c	7 ^c	NA^b
Charles, 2014	23 adults	Haiti	11	14 days	(77) ^f	(91) ^c	19 ^c	19 ^c
	45 (6 to 17 years)		27		(69) ^f	(74) ^c	11 ^c	10 ^c
	42 (1–4 years)		16		(64) ^f	(73) ^c	9 ^c	10 ^c
Kanungo, 2015	96 (15+ years)	India	171	14 days	67 (70)	58 (60)	7	5
	90 (6–14 years)		50	14 days	(88)	(79)	26	14
	91 (15+ years)		238	14 days	(57)	(51)	5	4
	93 (6–14 years)		81	14 days	(85)	(82)	33	16
Kanungo, 2015	86 adults (≥18 years)	India	191	14 days	59 (69)	47 (55)	7	5
			144	28 days	55 (66)	49 (58)	9	5
	84 children (1–17 years)		47	14 days	72 (86)	67 (80)	30	18
			89	28 days	73 (89)	63 (77)	21	11
Aloysia, 2015	112 (15+ years)	Philippines	36	14 days	(83)	(78)	25	18
	112 (5–14 years)		3		(88)	(87)	58	49
	112 (1–4 years)		1		(88)	(89)	67	67
Desai, 2015	54 (18+ years)	Ethiopia	16	14 days	37 (70)	43 (81)	11	15
	53 (1–17 years)		6		39 (74)	41 (77)	13	13
Ivers, 2015	25 HIV+ adults	Haiti	11	14 days	(65)^c	(74) ^c	7 ^c	7 ^c
	25 HIV– adults		11		(82) ^f	(91) ^c	17 ^c	20^c
Baik, 2014	20 adults	Korea	4	14 days	18 (90)	19 (95)	74	94
Baik, 2015	Shanchol 376 adults 235 (1–17 years)	Philippines	36	14 days	315 (84)	287 (76)	30	21
			12		198 (84)	209 (89)	51	52
	Euvichol 366 adults 236 (1–17 years)		36		317(84)	308 (82)	32	22
			12		198 (86)	202 (87)	55	51
Saha, 2016	143 adults^d	Bangladesh	99	14 days	109 (76)^c	105 (73)^c	11^c	9^c
Iyer, 2016	37 (1–5 years) 67 (6–17 years) 101 adults (18–59 years)	South Sudan	11	~21 days	9 (75)	12 (80)	11	9
			30		8 (53)	12 (38)	2	3
			22		28 (61)	31 (57)	8	7
Matias, 2016	22 adults	Haiti	29	14 days	16 (73)^c	17 (81)^c	9^c	9^c

Table 2.

Open in new tab

Vibriocidal Immune Responses to Inaba Serotype Following Killed Oral Cholera Vaccination

Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	No. (%) Who Seroconverted After:		Geometric Mean Fold Rise After:
Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	1st Dose^a	2nd Dose^a	1st Dose^a	2nd Dose^a
Bivalent oral cholera vaccine
Kanungo, 2009	37 (18+ years)	India	186	14 days	24 (65)	17 (46)	9	5
	39 (1–17 years)		37	14 days	34 (87)	32 (82)	47	24
Saha, 2011	53 (18–45 years)	Bangladesh	55	14 days	(60)^f	(57)^c	9 ^c	NA^b
	55 (2–4 years)		55		(78)^f	(76) ^c	12 ^c	NA^b
	54 (12–24 months)		8		(52)^f	(72) ^c	7 ^c	NA^b
Charles, 2014	23 adults	Haiti	11	14 days	(77) ^f	(91) ^c	19 ^c	19 ^c
	45 (6 to 17 years)		27		(69) ^f	(74) ^c	11 ^c	10 ^c
	42 (1–4 years)		16		(64) ^f	(73) ^c	9 ^c	10 ^c
Kanungo, 2015	96 (15+ years)	India	171	14 days	67 (70)	58 (60)	7	5
	90 (6–14 years)		50	14 days	(88)	(79)	26	14
	91 (15+ years)		238	14 days	(57)	(51)	5	4
	93 (6–14 years)		81	14 days	(85)	(82)	33	16
Kanungo, 2015	86 adults (≥18 years)	India	191	14 days	59 (69)	47 (55)	7	5
			144	28 days	55 (66)	49 (58)	9	5
	84 children (1–17 years)		47	14 days	72 (86)	67 (80)	30	18
			89	28 days	73 (89)	63 (77)	21	11
Aloysia, 2015	112 (15+ years)	Philippines	36	14 days	(83)	(78)	25	18
	112 (5–14 years)		3		(88)	(87)	58	49
	112 (1–4 years)		1		(88)	(89)	67	67
Desai, 2015	54 (18+ years)	Ethiopia	16	14 days	37 (70)	43 (81)	11	15
	53 (1–17 years)		6		39 (74)	41 (77)	13	13
Ivers, 2015	25 HIV+ adults	Haiti	11	14 days	(65)^c	(74) ^c	7 ^c	7 ^c
	25 HIV– adults		11		(82) ^f	(91) ^c	17 ^c	20^c
Baik, 2014	20 adults	Korea	4	14 days	18 (90)	19 (95)	74	94
Baik, 2015	Shanchol 376 adults 235 (1–17 years)	Philippines	36	14 days	315 (84)	287 (76)	30	21
			12		198 (84)	209 (89)	51	52
	Euvichol 366 adults 236 (1–17 years)		36		317(84)	308 (82)	32	22
			12		198 (86)	202 (87)	55	51
Saha, 2016	143 adults^d	Bangladesh	99	14 days	109 (76)^c	105 (73)^c	11^c	9^c
Iyer, 2016	37 (1–5 years) 67 (6–17 years) 101 adults (18–59 years)	South Sudan	11	~21 days	9 (75)	12 (80)	11	9
			30		8 (53)	12 (38)	2	3
			22		28 (61)	31 (57)	8	7
Matias, 2016	22 adults	Haiti	29	14 days	16 (73)^c	17 (81)^c	9^c	9^c

Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	No. (%) Who Seroconverted After:		Geometric Mean Fold Rise After:
Study	Number of Participants (Age Group)	Study Site	Baseline Geometric Mean Titers	Interval Between Doses, days	1st Dose^a	2nd Dose^a	1st Dose^a	2nd Dose^a
Bivalent oral cholera vaccine
Kanungo, 2009	37 (18+ years)	India	186	14 days	24 (65)	17 (46)	9	5
	39 (1–17 years)		37	14 days	34 (87)	32 (82)	47	24
Saha, 2011	53 (18–45 years)	Bangladesh	55	14 days	(60)^f	(57)^c	9 ^c	NA^b
	55 (2–4 years)		55		(78)^f	(76) ^c	12 ^c	NA^b
	54 (12–24 months)		8		(52)^f	(72) ^c	7 ^c	NA^b
Charles, 2014	23 adults	Haiti	11	14 days	(77) ^f	(91) ^c	19 ^c	19 ^c
	45 (6 to 17 years)		27		(69) ^f	(74) ^c	11 ^c	10 ^c
	42 (1–4 years)		16		(64) ^f	(73) ^c	9 ^c	10 ^c
Kanungo, 2015	96 (15+ years)	India	171	14 days	67 (70)	58 (60)	7	5
	90 (6–14 years)		50	14 days	(88)	(79)	26	14
	91 (15+ years)		238	14 days	(57)	(51)	5	4
	93 (6–14 years)		81	14 days	(85)	(82)	33	16
Kanungo, 2015	86 adults (≥18 years)	India	191	14 days	59 (69)	47 (55)	7	5
			144	28 days	55 (66)	49 (58)	9	5
	84 children (1–17 years)		47	14 days	72 (86)	67 (80)	30	18
			89	28 days	73 (89)	63 (77)	21	11
Aloysia, 2015	112 (15+ years)	Philippines	36	14 days	(83)	(78)	25	18
	112 (5–14 years)		3		(88)	(87)	58	49
	112 (1–4 years)		1		(88)	(89)	67	67
Desai, 2015	54 (18+ years)	Ethiopia	16	14 days	37 (70)	43 (81)	11	15
	53 (1–17 years)		6		39 (74)	41 (77)	13	13
Ivers, 2015	25 HIV+ adults	Haiti	11	14 days	(65)^c	(74) ^c	7 ^c	7 ^c
	25 HIV– adults		11		(82) ^f	(91) ^c	17 ^c	20^c
Baik, 2014	20 adults	Korea	4	14 days	18 (90)	19 (95)	74	94
Baik, 2015	Shanchol 376 adults 235 (1–17 years)	Philippines	36	14 days	315 (84)	287 (76)	30	21
			12		198 (84)	209 (89)	51	52
	Euvichol 366 adults 236 (1–17 years)		36		317(84)	308 (82)	32	22
			12		198 (86)	202 (87)	55	51
Saha, 2016	143 adults^d	Bangladesh	99	14 days	109 (76)^c	105 (73)^c	11^c	9^c
Iyer, 2016	37 (1–5 years) 67 (6–17 years) 101 adults (18–59 years)	South Sudan	11	~21 days	9 (75)	12 (80)	11	9
			30		8 (53)	12 (38)	2	3
			22		28 (61)	31 (57)	8	7
Matias, 2016	22 adults	Haiti	29	14 days	16 (73)^c	17 (81)^c	9^c	9^c

See References Listed in Supplementary Data.

Abbreviation: HIV, human immunodeficiency virus.

Blood for vibriocidal tests was obtained at 14 days after said dose, unless otherwise specified.

Not available.

Blood for vibriocidal tests was obtained on 7th day after said dose, ie, 7 and 21 days after the first dose.

Results included are only for those who received vaccine at the current storage recommendation of 2°C–8°C.

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