AChE activity, quantified as k3 of MP4A, was significantly decreased in MCI compared to controls (controls mean = 0.064, SD 0.006; MCI mean = 0.057, SD 0.007, t(28) = 3.105, P = 0.004). This effect was most pronounced in the lateral temporal, parietal and occipital lobes, but also encompassed the hippocampi, adjacent medial temporal structures, and frontal areas (Fig. 1 and Table 2) in two clusters of 39 720 and 26 voxels, respectively. For a detailed list of the structures comprising the clusters and the number of significant voxels within each structure see Supplementary Table 3. A voxel-wise analysis revealed no areas where AChE activity was greater in MCI than in controls.

Table 2
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Cortical AChE activity is reduced in MCI due to Alzheimer’s disease

StructureLocal maxima
SideP (FWE-corr.)xyz
Inferior temporal gyrusRight<0.00162−24−24
Middle temporal gyrusRight<0.00156−14−16
Inferior temporal gyrusRight<0.00160−36−20
Right<0.00162−40−18
Right<0.00156−58−16
Planum polareRight<0.00140−220
Middle temporal gyrusLeft<0.001−54−26−8
Planum polareLeft<0.001−42−20−6
Middle temporal gyrusLeft<0.001−54−30−8
Left<0.001−52−12−14
Left<0.001−54−16−12
Left<0.001−48−24−10
StructureLocal maxima
SideP (FWE-corr.)xyz
Inferior temporal gyrusRight<0.00162−24−24
Middle temporal gyrusRight<0.00156−14−16
Inferior temporal gyrusRight<0.00160−36−20
Right<0.00162−40−18
Right<0.00156−58−16
Planum polareRight<0.00140−220
Middle temporal gyrusLeft<0.001−54−26−8
Planum polareLeft<0.001−42−20−6
Middle temporal gyrusLeft<0.001−54−30−8
Left<0.001−52−12−14
Left<0.001−54−16−12
Left<0.001−48−24−10

P < 0.05, FWE-corrected with cluster free threshold enhancement. Side: left or right hemisphere.

Table 2
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Cortical AChE activity is reduced in MCI due to Alzheimer’s disease

StructureLocal maxima
SideP (FWE-corr.)xyz
Inferior temporal gyrusRight<0.00162−24−24
Middle temporal gyrusRight<0.00156−14−16
Inferior temporal gyrusRight<0.00160−36−20
Right<0.00162−40−18
Right<0.00156−58−16
Planum polareRight<0.00140−220
Middle temporal gyrusLeft<0.001−54−26−8
Planum polareLeft<0.001−42−20−6
Middle temporal gyrusLeft<0.001−54−30−8
Left<0.001−52−12−14
Left<0.001−54−16−12
Left<0.001−48−24−10
StructureLocal maxima
SideP (FWE-corr.)xyz
Inferior temporal gyrusRight<0.00162−24−24
Middle temporal gyrusRight<0.00156−14−16
Inferior temporal gyrusRight<0.00160−36−20
Right<0.00162−40−18
Right<0.00156−58−16
Planum polareRight<0.00140−220
Middle temporal gyrusLeft<0.001−54−26−8
Planum polareLeft<0.001−42−20−6
Middle temporal gyrusLeft<0.001−54−30−8
Left<0.001−52−12−14
Left<0.001−54−16−12
Left<0.001−48−24−10

P < 0.05, FWE-corrected with cluster free threshold enhancement. Side: left or right hemisphere.

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