Table 5.

Predictors of Full Compliance Among Randomized Participants Postenrollment and Postvaccination

6 Months Postenrollment (All Participants, n = 8626)6 Months Postvaccination (All Vaccinated, n = 7979)
CompliantUnivariableMultivariableCompliantUnivariableMultivariable
N (%)Odds Ratio (95% CI)Factor- Level
P Value
N (%)Factor- Level
P Value
N (%)Odds Ratio (95% CI)Factor Level
P Value
Odds Ratio (95% CI)Factor- Level
P Value
Randomization ArmDeferred Vaccination2769 (64.2)ref<.0001ref<.00012455 (64.4)ref<.0001ref<.0001
Immediate Vaccination3165 (73.4)1.5 (1.4–1.7)1.6 (1.4–1.7)3165 (76.1)1.8 (1.6–1.9)1.9 (1.7–2.1)
Enrollment SiteWestern Rural1189 (62.9)ref<.0001ref<.00011118 (64.1)ref<.0001ref<.0001
Western Urban2176 (67.1)1.2 (1.1–1.4)0.9 (0.8–1.1)2021 (69.5)1.3 (1.1–1.4)1.1 (0.9–1.2)
Bombali989 (82.3)2.7 (2.3–3.3)2.1 (1.8–2.6)861 (75.7)1.7 (1.5–2.1)1.5 (1.2–1.8)
Tonkolili523 (71.5)1.5 (1.2–1.8)1.2 (1.0–1.4)595 (84.6)3.1 (2.5–3.9)2.6 (2.1–3.3)
Port Loko (Port Loko)523 (60.7)0.9 (0.8–1.1)0.8 (0.6–0.9)508 (61.8)0.9 (0.8–1.1)0.8 (0.7–1.0)
Port Loko (Lunsar)296 (74.7)1.8 (1.4–2.2)1.4 (1.1–1.9)284 (78.0)2.0 (1.5–2.6)1.7 (1.3–2.3)
Port Loko (Kaffu Bullom)238 (79.1)2.2 (1.7–3.0)1.7 (1.3–2.3)233 (80.3)2.3 (1.7–3.1)2.0 (1.4–2.7)
Age (tertiled) years18.0–27.51820 (63.3)ref<.0001ref<.00011747 (65.8)ref<.0001ref<.0001
27.5–35.42017 (70.1)1.4 (1.2–1.5)1.3 (1.2–1.5)1896 (71.9)1.3 (1.2–1.5)1.3 (1.1–1.4)
35.4–79.52097 (72.9)1.6 (1.4–1.8)1.4 (1.3–1.6)1977 (73.9)1.5 (1.3–1.7)1.3 (1.2–1.5)
GenderMale3568 (68.2)ref.17613466 (69.0)ref.0001
Female2366 (69.6)1.1 (1.0–1.2)2154 (73.1)1.2 (1.1–1.4)
OccupationNursea2071 (72.1)ref<.0001ref<.00011769 (75.8)ref<.0001ref<.0001
Doctor19 (79.2)1.5 (0.6–3.9)1.3 (0.5–3.4)16 (80)1.3 (0.4–3.8)1.0 (0.3–3.0)
Pharmacist25 (64.1)0.7 (0.4–1.3)0.6 (0.3–1.2)25 (64.1)0.6 (0.3–1.1)0.6 (0.3–1.1)
Allied Health Professionalb101 (67.8)0.8 (0.6–1.2)0.8 (0.5–1.1)93 (71.5)0.8 (0.5–1.2)0.8 (0.5–1.2)
Community health worker110 (61.8)0.6 (0.5–0.9)0.7 (0.5–0.9)97 (64.2)0.6 (0.4–0.8)0.6 (0.4–0.8)
Laboratory worker218 (80.1)1.6 (1.2–2.1)1.6 (1.2–2.2)216 (80.3)1.3 (0.9–1.8)1.5 (1.1–2.0)
Frontline workerc2716 (65.4)0.7 (0.7–0.8)0.8 (0.8–0.9)2281 (67.7)0.7 (0.6–0.8)0.8 (0.7–0.9)
Surveillance worker361 (72.8)1.0 (0.8–1.3)1.2 (1.0–1.5)312 (76.1)1.0 (0.8–1.3)1.2 (0.9–1.6)
Other/Not reported313 (70.7)0.9 (0.8–1.2)1.0 (0.8–1.2)256 (72.9)0.9 (0.7–1.1)0.9 (0.7–1.1)
Not currently workingdNANANA555 (62.2)0.5 (0.5–0.6)0.9 (0.6–1.2)
Facility TypeClinic setting1140 (71.7)ref<.0001ref<.00011154 (71.1)ref<.0001ref<.0001
Ebola Facility1855 (62.2)0.7 (0.6–0.7)0.8 (0.7–0.9)1393 (65.8)0.8 (0.7–0.9)0.8 (0.7–0.9)
Hospital2524 (73.5)1.1 (1.0–1.3)1.2 (1.0–1.3)2279 (75.6)1.3 (1.1–1.4)1.1 (0.9–1.3)
Other/Not reported415 (67)0.8 (0.7–1.0)1.0 (0.8–1.2)794 (65.5)0.8 (0.7–0.9)1.0 (0.7–1.3)
Vaccination StatusUnvaccinated2769 (62.1)ref<.0001
Vaccinated3165 (75.9)1.9 (1.8–2.1)
6 Months Postenrollment (All Participants, n = 8626)6 Months Postvaccination (All Vaccinated, n = 7979)
CompliantUnivariableMultivariableCompliantUnivariableMultivariable
N (%)Odds Ratio (95% CI)Factor- Level
P Value
N (%)Factor- Level
P Value
N (%)Odds Ratio (95% CI)Factor Level
P Value
Odds Ratio (95% CI)Factor- Level
P Value
Randomization ArmDeferred Vaccination2769 (64.2)ref<.0001ref<.00012455 (64.4)ref<.0001ref<.0001
Immediate Vaccination3165 (73.4)1.5 (1.4–1.7)1.6 (1.4–1.7)3165 (76.1)1.8 (1.6–1.9)1.9 (1.7–2.1)
Enrollment SiteWestern Rural1189 (62.9)ref<.0001ref<.00011118 (64.1)ref<.0001ref<.0001
Western Urban2176 (67.1)1.2 (1.1–1.4)0.9 (0.8–1.1)2021 (69.5)1.3 (1.1–1.4)1.1 (0.9–1.2)
Bombali989 (82.3)2.7 (2.3–3.3)2.1 (1.8–2.6)861 (75.7)1.7 (1.5–2.1)1.5 (1.2–1.8)
Tonkolili523 (71.5)1.5 (1.2–1.8)1.2 (1.0–1.4)595 (84.6)3.1 (2.5–3.9)2.6 (2.1–3.3)
Port Loko (Port Loko)523 (60.7)0.9 (0.8–1.1)0.8 (0.6–0.9)508 (61.8)0.9 (0.8–1.1)0.8 (0.7–1.0)
Port Loko (Lunsar)296 (74.7)1.8 (1.4–2.2)1.4 (1.1–1.9)284 (78.0)2.0 (1.5–2.6)1.7 (1.3–2.3)
Port Loko (Kaffu Bullom)238 (79.1)2.2 (1.7–3.0)1.7 (1.3–2.3)233 (80.3)2.3 (1.7–3.1)2.0 (1.4–2.7)
Age (tertiled) years18.0–27.51820 (63.3)ref<.0001ref<.00011747 (65.8)ref<.0001ref<.0001
27.5–35.42017 (70.1)1.4 (1.2–1.5)1.3 (1.2–1.5)1896 (71.9)1.3 (1.2–1.5)1.3 (1.1–1.4)
35.4–79.52097 (72.9)1.6 (1.4–1.8)1.4 (1.3–1.6)1977 (73.9)1.5 (1.3–1.7)1.3 (1.2–1.5)
GenderMale3568 (68.2)ref.17613466 (69.0)ref.0001
Female2366 (69.6)1.1 (1.0–1.2)2154 (73.1)1.2 (1.1–1.4)
OccupationNursea2071 (72.1)ref<.0001ref<.00011769 (75.8)ref<.0001ref<.0001
Doctor19 (79.2)1.5 (0.6–3.9)1.3 (0.5–3.4)16 (80)1.3 (0.4–3.8)1.0 (0.3–3.0)
Pharmacist25 (64.1)0.7 (0.4–1.3)0.6 (0.3–1.2)25 (64.1)0.6 (0.3–1.1)0.6 (0.3–1.1)
Allied Health Professionalb101 (67.8)0.8 (0.6–1.2)0.8 (0.5–1.1)93 (71.5)0.8 (0.5–1.2)0.8 (0.5–1.2)
Community health worker110 (61.8)0.6 (0.5–0.9)0.7 (0.5–0.9)97 (64.2)0.6 (0.4–0.8)0.6 (0.4–0.8)
Laboratory worker218 (80.1)1.6 (1.2–2.1)1.6 (1.2–2.2)216 (80.3)1.3 (0.9–1.8)1.5 (1.1–2.0)
Frontline workerc2716 (65.4)0.7 (0.7–0.8)0.8 (0.8–0.9)2281 (67.7)0.7 (0.6–0.8)0.8 (0.7–0.9)
Surveillance worker361 (72.8)1.0 (0.8–1.3)1.2 (1.0–1.5)312 (76.1)1.0 (0.8–1.3)1.2 (0.9–1.6)
Other/Not reported313 (70.7)0.9 (0.8–1.2)1.0 (0.8–1.2)256 (72.9)0.9 (0.7–1.1)0.9 (0.7–1.1)
Not currently workingdNANANA555 (62.2)0.5 (0.5–0.6)0.9 (0.6–1.2)
Facility TypeClinic setting1140 (71.7)ref<.0001ref<.00011154 (71.1)ref<.0001ref<.0001
Ebola Facility1855 (62.2)0.7 (0.6–0.7)0.8 (0.7–0.9)1393 (65.8)0.8 (0.7–0.9)0.8 (0.7–0.9)
Hospital2524 (73.5)1.1 (1.0–1.3)1.2 (1.0–1.3)2279 (75.6)1.3 (1.1–1.4)1.1 (0.9–1.3)
Other/Not reported415 (67)0.8 (0.7–1.0)1.0 (0.8–1.2)794 (65.5)0.8 (0.7–0.9)1.0 (0.7–1.3)
Vaccination StatusUnvaccinated2769 (62.1)ref<.0001
Vaccinated3165 (75.9)1.9 (1.8–2.1)

Abbreviations: CI, confidence interval; ref, reference category; NA, not applicable.

aIncludes nurse, midwife, community health nurse, nursing aide, maternal-child health aide, nursing student, and vaccinator.

bIncludes pharmacist, dentist, medical counselor, nutritionist, and physiotherapist.

cIncludes contact tracers, ambulance crew, burial workers, cleaners, and swabbers (persons taking post mortem skin/mucosal swabs for Ebola testing).

dCurrent occupation information was updated for deferred crossover participants during the crossover period. Many were no longer working as the Ebola outbreak subsided, and Ebola response jobs ended. Crossover participants were offered vaccination regardless of work status.

Table 5.

Predictors of Full Compliance Among Randomized Participants Postenrollment and Postvaccination

6 Months Postenrollment (All Participants, n = 8626)6 Months Postvaccination (All Vaccinated, n = 7979)
CompliantUnivariableMultivariableCompliantUnivariableMultivariable
N (%)Odds Ratio (95% CI)Factor- Level
P Value
N (%)Factor- Level
P Value
N (%)Odds Ratio (95% CI)Factor Level
P Value
Odds Ratio (95% CI)Factor- Level
P Value
Randomization ArmDeferred Vaccination2769 (64.2)ref<.0001ref<.00012455 (64.4)ref<.0001ref<.0001
Immediate Vaccination3165 (73.4)1.5 (1.4–1.7)1.6 (1.4–1.7)3165 (76.1)1.8 (1.6–1.9)1.9 (1.7–2.1)
Enrollment SiteWestern Rural1189 (62.9)ref<.0001ref<.00011118 (64.1)ref<.0001ref<.0001
Western Urban2176 (67.1)1.2 (1.1–1.4)0.9 (0.8–1.1)2021 (69.5)1.3 (1.1–1.4)1.1 (0.9–1.2)
Bombali989 (82.3)2.7 (2.3–3.3)2.1 (1.8–2.6)861 (75.7)1.7 (1.5–2.1)1.5 (1.2–1.8)
Tonkolili523 (71.5)1.5 (1.2–1.8)1.2 (1.0–1.4)595 (84.6)3.1 (2.5–3.9)2.6 (2.1–3.3)
Port Loko (Port Loko)523 (60.7)0.9 (0.8–1.1)0.8 (0.6–0.9)508 (61.8)0.9 (0.8–1.1)0.8 (0.7–1.0)
Port Loko (Lunsar)296 (74.7)1.8 (1.4–2.2)1.4 (1.1–1.9)284 (78.0)2.0 (1.5–2.6)1.7 (1.3–2.3)
Port Loko (Kaffu Bullom)238 (79.1)2.2 (1.7–3.0)1.7 (1.3–2.3)233 (80.3)2.3 (1.7–3.1)2.0 (1.4–2.7)
Age (tertiled) years18.0–27.51820 (63.3)ref<.0001ref<.00011747 (65.8)ref<.0001ref<.0001
27.5–35.42017 (70.1)1.4 (1.2–1.5)1.3 (1.2–1.5)1896 (71.9)1.3 (1.2–1.5)1.3 (1.1–1.4)
35.4–79.52097 (72.9)1.6 (1.4–1.8)1.4 (1.3–1.6)1977 (73.9)1.5 (1.3–1.7)1.3 (1.2–1.5)
GenderMale3568 (68.2)ref.17613466 (69.0)ref.0001
Female2366 (69.6)1.1 (1.0–1.2)2154 (73.1)1.2 (1.1–1.4)
OccupationNursea2071 (72.1)ref<.0001ref<.00011769 (75.8)ref<.0001ref<.0001
Doctor19 (79.2)1.5 (0.6–3.9)1.3 (0.5–3.4)16 (80)1.3 (0.4–3.8)1.0 (0.3–3.0)
Pharmacist25 (64.1)0.7 (0.4–1.3)0.6 (0.3–1.2)25 (64.1)0.6 (0.3–1.1)0.6 (0.3–1.1)
Allied Health Professionalb101 (67.8)0.8 (0.6–1.2)0.8 (0.5–1.1)93 (71.5)0.8 (0.5–1.2)0.8 (0.5–1.2)
Community health worker110 (61.8)0.6 (0.5–0.9)0.7 (0.5–0.9)97 (64.2)0.6 (0.4–0.8)0.6 (0.4–0.8)
Laboratory worker218 (80.1)1.6 (1.2–2.1)1.6 (1.2–2.2)216 (80.3)1.3 (0.9–1.8)1.5 (1.1–2.0)
Frontline workerc2716 (65.4)0.7 (0.7–0.8)0.8 (0.8–0.9)2281 (67.7)0.7 (0.6–0.8)0.8 (0.7–0.9)
Surveillance worker361 (72.8)1.0 (0.8–1.3)1.2 (1.0–1.5)312 (76.1)1.0 (0.8–1.3)1.2 (0.9–1.6)
Other/Not reported313 (70.7)0.9 (0.8–1.2)1.0 (0.8–1.2)256 (72.9)0.9 (0.7–1.1)0.9 (0.7–1.1)
Not currently workingdNANANA555 (62.2)0.5 (0.5–0.6)0.9 (0.6–1.2)
Facility TypeClinic setting1140 (71.7)ref<.0001ref<.00011154 (71.1)ref<.0001ref<.0001
Ebola Facility1855 (62.2)0.7 (0.6–0.7)0.8 (0.7–0.9)1393 (65.8)0.8 (0.7–0.9)0.8 (0.7–0.9)
Hospital2524 (73.5)1.1 (1.0–1.3)1.2 (1.0–1.3)2279 (75.6)1.3 (1.1–1.4)1.1 (0.9–1.3)
Other/Not reported415 (67)0.8 (0.7–1.0)1.0 (0.8–1.2)794 (65.5)0.8 (0.7–0.9)1.0 (0.7–1.3)
Vaccination StatusUnvaccinated2769 (62.1)ref<.0001
Vaccinated3165 (75.9)1.9 (1.8–2.1)
6 Months Postenrollment (All Participants, n = 8626)6 Months Postvaccination (All Vaccinated, n = 7979)
CompliantUnivariableMultivariableCompliantUnivariableMultivariable
N (%)Odds Ratio (95% CI)Factor- Level
P Value
N (%)Factor- Level
P Value
N (%)Odds Ratio (95% CI)Factor Level
P Value
Odds Ratio (95% CI)Factor- Level
P Value
Randomization ArmDeferred Vaccination2769 (64.2)ref<.0001ref<.00012455 (64.4)ref<.0001ref<.0001
Immediate Vaccination3165 (73.4)1.5 (1.4–1.7)1.6 (1.4–1.7)3165 (76.1)1.8 (1.6–1.9)1.9 (1.7–2.1)
Enrollment SiteWestern Rural1189 (62.9)ref<.0001ref<.00011118 (64.1)ref<.0001ref<.0001
Western Urban2176 (67.1)1.2 (1.1–1.4)0.9 (0.8–1.1)2021 (69.5)1.3 (1.1–1.4)1.1 (0.9–1.2)
Bombali989 (82.3)2.7 (2.3–3.3)2.1 (1.8–2.6)861 (75.7)1.7 (1.5–2.1)1.5 (1.2–1.8)
Tonkolili523 (71.5)1.5 (1.2–1.8)1.2 (1.0–1.4)595 (84.6)3.1 (2.5–3.9)2.6 (2.1–3.3)
Port Loko (Port Loko)523 (60.7)0.9 (0.8–1.1)0.8 (0.6–0.9)508 (61.8)0.9 (0.8–1.1)0.8 (0.7–1.0)
Port Loko (Lunsar)296 (74.7)1.8 (1.4–2.2)1.4 (1.1–1.9)284 (78.0)2.0 (1.5–2.6)1.7 (1.3–2.3)
Port Loko (Kaffu Bullom)238 (79.1)2.2 (1.7–3.0)1.7 (1.3–2.3)233 (80.3)2.3 (1.7–3.1)2.0 (1.4–2.7)
Age (tertiled) years18.0–27.51820 (63.3)ref<.0001ref<.00011747 (65.8)ref<.0001ref<.0001
27.5–35.42017 (70.1)1.4 (1.2–1.5)1.3 (1.2–1.5)1896 (71.9)1.3 (1.2–1.5)1.3 (1.1–1.4)
35.4–79.52097 (72.9)1.6 (1.4–1.8)1.4 (1.3–1.6)1977 (73.9)1.5 (1.3–1.7)1.3 (1.2–1.5)
GenderMale3568 (68.2)ref.17613466 (69.0)ref.0001
Female2366 (69.6)1.1 (1.0–1.2)2154 (73.1)1.2 (1.1–1.4)
OccupationNursea2071 (72.1)ref<.0001ref<.00011769 (75.8)ref<.0001ref<.0001
Doctor19 (79.2)1.5 (0.6–3.9)1.3 (0.5–3.4)16 (80)1.3 (0.4–3.8)1.0 (0.3–3.0)
Pharmacist25 (64.1)0.7 (0.4–1.3)0.6 (0.3–1.2)25 (64.1)0.6 (0.3–1.1)0.6 (0.3–1.1)
Allied Health Professionalb101 (67.8)0.8 (0.6–1.2)0.8 (0.5–1.1)93 (71.5)0.8 (0.5–1.2)0.8 (0.5–1.2)
Community health worker110 (61.8)0.6 (0.5–0.9)0.7 (0.5–0.9)97 (64.2)0.6 (0.4–0.8)0.6 (0.4–0.8)
Laboratory worker218 (80.1)1.6 (1.2–2.1)1.6 (1.2–2.2)216 (80.3)1.3 (0.9–1.8)1.5 (1.1–2.0)
Frontline workerc2716 (65.4)0.7 (0.7–0.8)0.8 (0.8–0.9)2281 (67.7)0.7 (0.6–0.8)0.8 (0.7–0.9)
Surveillance worker361 (72.8)1.0 (0.8–1.3)1.2 (1.0–1.5)312 (76.1)1.0 (0.8–1.3)1.2 (0.9–1.6)
Other/Not reported313 (70.7)0.9 (0.8–1.2)1.0 (0.8–1.2)256 (72.9)0.9 (0.7–1.1)0.9 (0.7–1.1)
Not currently workingdNANANA555 (62.2)0.5 (0.5–0.6)0.9 (0.6–1.2)
Facility TypeClinic setting1140 (71.7)ref<.0001ref<.00011154 (71.1)ref<.0001ref<.0001
Ebola Facility1855 (62.2)0.7 (0.6–0.7)0.8 (0.7–0.9)1393 (65.8)0.8 (0.7–0.9)0.8 (0.7–0.9)
Hospital2524 (73.5)1.1 (1.0–1.3)1.2 (1.0–1.3)2279 (75.6)1.3 (1.1–1.4)1.1 (0.9–1.3)
Other/Not reported415 (67)0.8 (0.7–1.0)1.0 (0.8–1.2)794 (65.5)0.8 (0.7–0.9)1.0 (0.7–1.3)
Vaccination StatusUnvaccinated2769 (62.1)ref<.0001
Vaccinated3165 (75.9)1.9 (1.8–2.1)

Abbreviations: CI, confidence interval; ref, reference category; NA, not applicable.

aIncludes nurse, midwife, community health nurse, nursing aide, maternal-child health aide, nursing student, and vaccinator.

bIncludes pharmacist, dentist, medical counselor, nutritionist, and physiotherapist.

cIncludes contact tracers, ambulance crew, burial workers, cleaners, and swabbers (persons taking post mortem skin/mucosal swabs for Ebola testing).

dCurrent occupation information was updated for deferred crossover participants during the crossover period. Many were no longer working as the Ebola outbreak subsided, and Ebola response jobs ended. Crossover participants were offered vaccination regardless of work status.

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