Severity of Adverse Events in Healthcare Workers Taking Treatment for Latent Tuberculosis Infection
| AE Severity . | INH (n = 82) . | RIF (n = 52) . | RPT/INH (n = 40) . |
|---|---|---|---|
| Grade 1 | 67 (82) | 42 (81) | 23 (58) |
| Grade 2 | 7 (9) | 8 (15) | 17 (41) |
| Grade 3 | 6 (7) | 2 (4) | 0 (0) |
| Grade 4 | 1 (1) | 0 (0) | 0 (0) |
| Nongraded | 1 (1) | 0 (0) | 0 (0) |
| Drug discontinuationa | 29 (35) | 11 (21) | 4 (10) |
| AE Severity . | INH (n = 82) . | RIF (n = 52) . | RPT/INH (n = 40) . |
|---|---|---|---|
| Grade 1 | 67 (82) | 42 (81) | 23 (58) |
| Grade 2 | 7 (9) | 8 (15) | 17 (41) |
| Grade 3 | 6 (7) | 2 (4) | 0 (0) |
| Grade 4 | 1 (1) | 0 (0) | 0 (0) |
| Nongraded | 1 (1) | 0 (0) | 0 (0) |
| Drug discontinuationa | 29 (35) | 11 (21) | 4 (10) |
Data are presented as No. (%).
Abbreviations: AE, adverse event; INH, isoniazid; RIF, rifampin; RPT, rifapentine.
aINH vs RPT/INH, P = .0042; INH vs RIF, P = not significant; RIF vs RPT/INH, P = not significant.
Severity of Adverse Events in Healthcare Workers Taking Treatment for Latent Tuberculosis Infection
| AE Severity . | INH (n = 82) . | RIF (n = 52) . | RPT/INH (n = 40) . |
|---|---|---|---|
| Grade 1 | 67 (82) | 42 (81) | 23 (58) |
| Grade 2 | 7 (9) | 8 (15) | 17 (41) |
| Grade 3 | 6 (7) | 2 (4) | 0 (0) |
| Grade 4 | 1 (1) | 0 (0) | 0 (0) |
| Nongraded | 1 (1) | 0 (0) | 0 (0) |
| Drug discontinuationa | 29 (35) | 11 (21) | 4 (10) |
| AE Severity . | INH (n = 82) . | RIF (n = 52) . | RPT/INH (n = 40) . |
|---|---|---|---|
| Grade 1 | 67 (82) | 42 (81) | 23 (58) |
| Grade 2 | 7 (9) | 8 (15) | 17 (41) |
| Grade 3 | 6 (7) | 2 (4) | 0 (0) |
| Grade 4 | 1 (1) | 0 (0) | 0 (0) |
| Nongraded | 1 (1) | 0 (0) | 0 (0) |
| Drug discontinuationa | 29 (35) | 11 (21) | 4 (10) |
Data are presented as No. (%).
Abbreviations: AE, adverse event; INH, isoniazid; RIF, rifampin; RPT, rifapentine.
aINH vs RPT/INH, P = .0042; INH vs RIF, P = not significant; RIF vs RPT/INH, P = not significant.
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