Organisms at Neutrophil Recovery Negatively or Positively Correlated With Subsequent Development of Severe Acute Graft-Versus-Host Disease
| Organism . | Correlation With Severe Acute Graft-Versus-Host Diseasea . | ||
|---|---|---|---|
| β/SEM(β) . | P (corr) . | Lineage . | |
| Erysipelatoclostridium ramosum | –1.7 | 2.92E-84 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Erysipelatoclostridium |
| Bacteroides thetaiotaomicron | –1.5 | 3.68E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Blautia luti | –1.4 | 2.92E-83 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Candidatus soleaferrea | –1.4 | 9.82E-66 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Butyricicoccus spp. | –1.4 | 1.35E-64 | Firmicutes; Clostridia; Clostridiales; Clostridiaceae |
| Blautia spp. | –1.3 | 7.26E-76 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Dorea spp. | –1.2 | 2.29E-64 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Ruminococcus spp. | –1.2 | 1.08E-44 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Clostridium clostridioforme | –1.2 | 2.17E-54 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Fusicatenibacter |
| Bacteroides ovatus | –1.2 | 8.73E-69 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Bacteroides caccae | –1.0 | 3.33E-51 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Roseburia hominis | 1.0 | 1.82E-39 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia |
| Eisenbergiella spp. | 1.0 | 3.96E-45 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Veillonella parvula | 1.0 | 2.32E-38 | Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Veillonella |
| Enterococcus faecium or hirae–like | 1.1 | 2.56E-61 | Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus |
| Lactobacillus salivarius | 1.1 | 3.94E-48 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Lactobacillus fermentum | 1.2 | 1.02E-66 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Bacteroides dorei | 1.3 | 1.59E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Solobacterium moorei | 1.3 | 1.93E-40 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Solobacterium |
| Rothia mucilaginosa | 1.4 | 1.05E-57 | Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Rothia |
| Organism . | Correlation With Severe Acute Graft-Versus-Host Diseasea . | ||
|---|---|---|---|
| β/SEM(β) . | P (corr) . | Lineage . | |
| Erysipelatoclostridium ramosum | –1.7 | 2.92E-84 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Erysipelatoclostridium |
| Bacteroides thetaiotaomicron | –1.5 | 3.68E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Blautia luti | –1.4 | 2.92E-83 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Candidatus soleaferrea | –1.4 | 9.82E-66 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Butyricicoccus spp. | –1.4 | 1.35E-64 | Firmicutes; Clostridia; Clostridiales; Clostridiaceae |
| Blautia spp. | –1.3 | 7.26E-76 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Dorea spp. | –1.2 | 2.29E-64 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Ruminococcus spp. | –1.2 | 1.08E-44 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Clostridium clostridioforme | –1.2 | 2.17E-54 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Fusicatenibacter |
| Bacteroides ovatus | –1.2 | 8.73E-69 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Bacteroides caccae | –1.0 | 3.33E-51 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Roseburia hominis | 1.0 | 1.82E-39 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia |
| Eisenbergiella spp. | 1.0 | 3.96E-45 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Veillonella parvula | 1.0 | 2.32E-38 | Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Veillonella |
| Enterococcus faecium or hirae–like | 1.1 | 2.56E-61 | Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus |
| Lactobacillus salivarius | 1.1 | 3.94E-48 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Lactobacillus fermentum | 1.2 | 1.02E-66 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Bacteroides dorei | 1.3 | 1.59E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Solobacterium moorei | 1.3 | 1.93E-40 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Solobacterium |
| Rothia mucilaginosa | 1.4 | 1.05E-57 | Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Rothia |
Severe graft-versus-host disease is grade 3–4.
aAn ANCOM (analysis of composition of microbiomes)–style [25] analysis was performed. β/SEM(β) is the Wald statistic. The Bonferroni correction was used to correct P. Neutrophil recovery is the third consecutive day of an absolute neutrophil count >500 cells per mm3.
Organisms at Neutrophil Recovery Negatively or Positively Correlated With Subsequent Development of Severe Acute Graft-Versus-Host Disease
| Organism . | Correlation With Severe Acute Graft-Versus-Host Diseasea . | ||
|---|---|---|---|
| β/SEM(β) . | P (corr) . | Lineage . | |
| Erysipelatoclostridium ramosum | –1.7 | 2.92E-84 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Erysipelatoclostridium |
| Bacteroides thetaiotaomicron | –1.5 | 3.68E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Blautia luti | –1.4 | 2.92E-83 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Candidatus soleaferrea | –1.4 | 9.82E-66 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Butyricicoccus spp. | –1.4 | 1.35E-64 | Firmicutes; Clostridia; Clostridiales; Clostridiaceae |
| Blautia spp. | –1.3 | 7.26E-76 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Dorea spp. | –1.2 | 2.29E-64 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Ruminococcus spp. | –1.2 | 1.08E-44 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Clostridium clostridioforme | –1.2 | 2.17E-54 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Fusicatenibacter |
| Bacteroides ovatus | –1.2 | 8.73E-69 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Bacteroides caccae | –1.0 | 3.33E-51 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Roseburia hominis | 1.0 | 1.82E-39 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia |
| Eisenbergiella spp. | 1.0 | 3.96E-45 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Veillonella parvula | 1.0 | 2.32E-38 | Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Veillonella |
| Enterococcus faecium or hirae–like | 1.1 | 2.56E-61 | Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus |
| Lactobacillus salivarius | 1.1 | 3.94E-48 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Lactobacillus fermentum | 1.2 | 1.02E-66 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Bacteroides dorei | 1.3 | 1.59E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Solobacterium moorei | 1.3 | 1.93E-40 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Solobacterium |
| Rothia mucilaginosa | 1.4 | 1.05E-57 | Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Rothia |
| Organism . | Correlation With Severe Acute Graft-Versus-Host Diseasea . | ||
|---|---|---|---|
| β/SEM(β) . | P (corr) . | Lineage . | |
| Erysipelatoclostridium ramosum | –1.7 | 2.92E-84 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Erysipelatoclostridium |
| Bacteroides thetaiotaomicron | –1.5 | 3.68E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Blautia luti | –1.4 | 2.92E-83 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Candidatus soleaferrea | –1.4 | 9.82E-66 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Butyricicoccus spp. | –1.4 | 1.35E-64 | Firmicutes; Clostridia; Clostridiales; Clostridiaceae |
| Blautia spp. | –1.3 | 7.26E-76 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia |
| Dorea spp. | –1.2 | 2.29E-64 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Ruminococcus spp. | –1.2 | 1.08E-44 | Firmicutes; Clostridia; Clostridiales; Ruminococcaceae |
| Clostridium clostridioforme | –1.2 | 2.17E-54 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Fusicatenibacter |
| Bacteroides ovatus | –1.2 | 8.73E-69 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Bacteroides caccae | –1.0 | 3.33E-51 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Roseburia hominis | 1.0 | 1.82E-39 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia |
| Eisenbergiella spp. | 1.0 | 3.96E-45 | Firmicutes; Clostridia; Clostridiales; Lachnospiraceae |
| Veillonella parvula | 1.0 | 2.32E-38 | Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Veillonella |
| Enterococcus faecium or hirae–like | 1.1 | 2.56E-61 | Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus |
| Lactobacillus salivarius | 1.1 | 3.94E-48 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Lactobacillus fermentum | 1.2 | 1.02E-66 | Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae; Lactobacillus |
| Bacteroides dorei | 1.3 | 1.59E-82 | Bacteroidetes/Chlorobi group; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides |
| Solobacterium moorei | 1.3 | 1.93E-40 | Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Solobacterium |
| Rothia mucilaginosa | 1.4 | 1.05E-57 | Actinobacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Rothia |
Severe graft-versus-host disease is grade 3–4.
aAn ANCOM (analysis of composition of microbiomes)–style [25] analysis was performed. β/SEM(β) is the Wald statistic. The Bonferroni correction was used to correct P. Neutrophil recovery is the third consecutive day of an absolute neutrophil count >500 cells per mm3.
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