Models and Variants Incorporating Different Antifilarial Effects and Different Assumptions on the Transmission Dynamics During the Trial
| Model . | Permanent Antifilarial Activity . | Variant . | Assumptions on Short-term and Long-term Changes in Transmission . |
|---|---|---|---|
| 0 | • No macrofilaricidal activity • No sterilizing activity | A | • Constant short-term transmission • Constant long-term transmission |
| 1 | • No macrofilaricidal activity • Sterilizing activity | B | • Seasonal short-term transmission • Constant long-term transmission |
| 2 | • Macrofilaricidal activity • No sterilizing activity | C | • Constant short-term transmission • Declining long-term transmission |
| 3 | • Macrofilaricidal activity • Sterilizing activity | D | • Seasonal short-term transmission • Declining long-term transmission |
| Model . | Permanent Antifilarial Activity . | Variant . | Assumptions on Short-term and Long-term Changes in Transmission . |
|---|---|---|---|
| 0 | • No macrofilaricidal activity • No sterilizing activity | A | • Constant short-term transmission • Constant long-term transmission |
| 1 | • No macrofilaricidal activity • Sterilizing activity | B | • Seasonal short-term transmission • Constant long-term transmission |
| 2 | • Macrofilaricidal activity • No sterilizing activity | C | • Constant short-term transmission • Declining long-term transmission |
| 3 | • Macrofilaricidal activity • Sterilizing activity | D | • Seasonal short-term transmission • Declining long-term transmission |
Nota bene: All variants A to D of models 0 to 3 were fitted to the data separately (ie, 16 separate fits in total).
Models and Variants Incorporating Different Antifilarial Effects and Different Assumptions on the Transmission Dynamics During the Trial
| Model . | Permanent Antifilarial Activity . | Variant . | Assumptions on Short-term and Long-term Changes in Transmission . |
|---|---|---|---|
| 0 | • No macrofilaricidal activity • No sterilizing activity | A | • Constant short-term transmission • Constant long-term transmission |
| 1 | • No macrofilaricidal activity • Sterilizing activity | B | • Seasonal short-term transmission • Constant long-term transmission |
| 2 | • Macrofilaricidal activity • No sterilizing activity | C | • Constant short-term transmission • Declining long-term transmission |
| 3 | • Macrofilaricidal activity • Sterilizing activity | D | • Seasonal short-term transmission • Declining long-term transmission |
| Model . | Permanent Antifilarial Activity . | Variant . | Assumptions on Short-term and Long-term Changes in Transmission . |
|---|---|---|---|
| 0 | • No macrofilaricidal activity • No sterilizing activity | A | • Constant short-term transmission • Constant long-term transmission |
| 1 | • No macrofilaricidal activity • Sterilizing activity | B | • Seasonal short-term transmission • Constant long-term transmission |
| 2 | • Macrofilaricidal activity • No sterilizing activity | C | • Constant short-term transmission • Declining long-term transmission |
| 3 | • Macrofilaricidal activity • Sterilizing activity | D | • Seasonal short-term transmission • Declining long-term transmission |
Nota bene: All variants A to D of models 0 to 3 were fitted to the data separately (ie, 16 separate fits in total).
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