Lifetime average daily number of cigarettes smoked and the risk of HNC by gender, in the INHANCE consortium
| Daily number of cigarettes smoked . | Men a . | Women b . | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR c . | 95% CI . | Cases . | Controls . | OR c . | 95% CI . | |
| Never | 853 | 4099 | 1.00 | 882 | 3763 | 1.00 | ||
| >0–3 | 141 | 480 | 1.39 | (0.96, 2.01) | 101 | 278 | 1.77 | (1.30, 2.40) |
| >3–5 | 160 | 409 | 2.05 | (1.39, 3.02) | 118 | 200 | 2.74 | (2.01, 3.74) |
| >5–10 | 854 | 1420 | 2.83 | (2.01, 3.98) | 330 | 556 | 2.67 | (2.02, 3.53) |
| Missing | 235 | 250 | 84 | 180 | ||||
| P- value | <0.01 | <0.01 | ||||||
| P for heterogeneity across studies | <0.01 | <0.01 | ||||||
| Daily number of cigarettes smoked . | Men a . | Women b . | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR c . | 95% CI . | Cases . | Controls . | OR c . | 95% CI . | |
| Never | 853 | 4099 | 1.00 | 882 | 3763 | 1.00 | ||
| >0–3 | 141 | 480 | 1.39 | (0.96, 2.01) | 101 | 278 | 1.77 | (1.30, 2.40) |
| >3–5 | 160 | 409 | 2.05 | (1.39, 3.02) | 118 | 200 | 2.74 | (2.01, 3.74) |
| >5–10 | 854 | 1420 | 2.83 | (2.01, 3.98) | 330 | 556 | 2.67 | (2.02, 3.53) |
| Missing | 235 | 250 | 84 | 180 | ||||
| P- value | <0.01 | <0.01 | ||||||
| P for heterogeneity across studies | <0.01 | <0.01 | ||||||
Adjusted on age (categorical), race, education level, centres and drinks per day (categorical).
a The Boston, North Carolina, Tampa, Switzerland and Seattle-LEO studies were not included.
b The Boston, Milan, Rome, Tampa and Germany-Heidelberg studies were not included.
c Random-effect models.
Lifetime average daily number of cigarettes smoked and the risk of HNC by gender, in the INHANCE consortium
| Daily number of cigarettes smoked . | Men a . | Women b . | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR c . | 95% CI . | Cases . | Controls . | OR c . | 95% CI . | |
| Never | 853 | 4099 | 1.00 | 882 | 3763 | 1.00 | ||
| >0–3 | 141 | 480 | 1.39 | (0.96, 2.01) | 101 | 278 | 1.77 | (1.30, 2.40) |
| >3–5 | 160 | 409 | 2.05 | (1.39, 3.02) | 118 | 200 | 2.74 | (2.01, 3.74) |
| >5–10 | 854 | 1420 | 2.83 | (2.01, 3.98) | 330 | 556 | 2.67 | (2.02, 3.53) |
| Missing | 235 | 250 | 84 | 180 | ||||
| P- value | <0.01 | <0.01 | ||||||
| P for heterogeneity across studies | <0.01 | <0.01 | ||||||
| Daily number of cigarettes smoked . | Men a . | Women b . | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR c . | 95% CI . | Cases . | Controls . | OR c . | 95% CI . | |
| Never | 853 | 4099 | 1.00 | 882 | 3763 | 1.00 | ||
| >0–3 | 141 | 480 | 1.39 | (0.96, 2.01) | 101 | 278 | 1.77 | (1.30, 2.40) |
| >3–5 | 160 | 409 | 2.05 | (1.39, 3.02) | 118 | 200 | 2.74 | (2.01, 3.74) |
| >5–10 | 854 | 1420 | 2.83 | (2.01, 3.98) | 330 | 556 | 2.67 | (2.02, 3.53) |
| Missing | 235 | 250 | 84 | 180 | ||||
| P- value | <0.01 | <0.01 | ||||||
| P for heterogeneity across studies | <0.01 | <0.01 | ||||||
Adjusted on age (categorical), race, education level, centres and drinks per day (categorical).
a The Boston, North Carolina, Tampa, Switzerland and Seattle-LEO studies were not included.
b The Boston, Milan, Rome, Tampa and Germany-Heidelberg studies were not included.
c Random-effect models.
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