Characteristics of Children Included in Study, Stratified by Maternal Thyroid Function in Early Pregnancy
| Characteristic . | No Maternal Thyroid Dysfunctiona . | Maternal Thyroid Dysfunctionb . |
|---|---|---|
| Children (n) | 1,008 | 145 |
| Birth year of the child | ||
| 1997–2000 | 503 (49.9) | 69 (47.6) |
| 2001–2003 | 505 (50.1) | 76 (52.4) |
| Child’s sex | ||
| Female | 475 (47.1) | 74 (51.0) |
| Male | 533 (52.9) | 71 (49.0) |
| Gestational age at birth | ||
| <37 wk | 25 (2.5) | 4 (2.8) |
| ≥37 wk | 983 (97.5) | 141 (97.2) |
| Birth weightc | ||
| <2500 g | 10 (1.0) | 3 (2.1) |
| ≥2500 g | 996 (99.0) | 142 (97.9) |
| 5-min Apgar scorec | ||
| 7–10 | 992 (99.4) | 145 (100.0) |
| 0–6 | 6 (0.6) | 0 (0) |
| Maternal parityc | ||
| Nulliparous | 533 (54.1) | 73 (52.1) |
| Multiparous | 453 (45.9) | 67 (47.9) |
| Maternal age | ||
| <30 y | 439 (43.6) | 68 (46.9) |
| ≥30 y | 569 (56.4) | 77 (53.1) |
| Maternal prepregnancy BMIc,d | ||
| <25 kg/m2 | 741 (75.3) | 96 (68.1) |
| ≥25 kg/m2 | 243 (24.7) | 45 (31.9) |
| Maternal smoking in pregnancyc,d | ||
| Yes | 329 (32.6) | 46 (31.7) |
| No | 679 (67.4) | 99 (68.3) |
| Maternal alcohol intake in pregnancyd | ||
| 0 units/wk | 455 (45.1) | 84 (57.9) |
| 1-4 units/wk | 439 (43.6) | 47 (32.4) |
| ≥5 units/wk | 114 (11.3) | 14 (9.7) |
| Maternal psychiatric diseased | ||
| Yes | 102 (10.1) | 13 (9.0) |
| No | 906 (89.9) | 132 (91.0) |
| Maternal IQe | ||
| Abnormal low | 150 (14.9) | 29 (20.0) |
| Normal | 858 (85.1) | 116 (80.0) |
| Parental educational levelc | ||
| <12 y | 267 (26.7) | 51 (35.2) |
| ≥12 y | 735 (73.3) | 94 (64.8) |
| Characteristic . | No Maternal Thyroid Dysfunctiona . | Maternal Thyroid Dysfunctionb . |
|---|---|---|
| Children (n) | 1,008 | 145 |
| Birth year of the child | ||
| 1997–2000 | 503 (49.9) | 69 (47.6) |
| 2001–2003 | 505 (50.1) | 76 (52.4) |
| Child’s sex | ||
| Female | 475 (47.1) | 74 (51.0) |
| Male | 533 (52.9) | 71 (49.0) |
| Gestational age at birth | ||
| <37 wk | 25 (2.5) | 4 (2.8) |
| ≥37 wk | 983 (97.5) | 141 (97.2) |
| Birth weightc | ||
| <2500 g | 10 (1.0) | 3 (2.1) |
| ≥2500 g | 996 (99.0) | 142 (97.9) |
| 5-min Apgar scorec | ||
| 7–10 | 992 (99.4) | 145 (100.0) |
| 0–6 | 6 (0.6) | 0 (0) |
| Maternal parityc | ||
| Nulliparous | 533 (54.1) | 73 (52.1) |
| Multiparous | 453 (45.9) | 67 (47.9) |
| Maternal age | ||
| <30 y | 439 (43.6) | 68 (46.9) |
| ≥30 y | 569 (56.4) | 77 (53.1) |
| Maternal prepregnancy BMIc,d | ||
| <25 kg/m2 | 741 (75.3) | 96 (68.1) |
| ≥25 kg/m2 | 243 (24.7) | 45 (31.9) |
| Maternal smoking in pregnancyc,d | ||
| Yes | 329 (32.6) | 46 (31.7) |
| No | 679 (67.4) | 99 (68.3) |
| Maternal alcohol intake in pregnancyd | ||
| 0 units/wk | 455 (45.1) | 84 (57.9) |
| 1-4 units/wk | 439 (43.6) | 47 (32.4) |
| ≥5 units/wk | 114 (11.3) | 14 (9.7) |
| Maternal psychiatric diseased | ||
| Yes | 102 (10.1) | 13 (9.0) |
| No | 906 (89.9) | 132 (91.0) |
| Maternal IQe | ||
| Abnormal low | 150 (14.9) | 29 (20.0) |
| Normal | 858 (85.1) | 116 (80.0) |
| Parental educational levelc | ||
| <12 y | 267 (26.7) | 51 (35.2) |
| ≥12 y | 735 (73.3) | 94 (64.8) |
Numbers are n (%).
TSH and fT4 between the pregnancy week–specific 2.5th and 97.5th percentiles.
TSH and/or fT4 outside the pregnancy week–specific 2.5th and 97.5th percentiles.
Individuals with missing values not included in the table.
Self-reported in the pregnancy.
Abnormal IQ defined by a score below the sample mean minus 1 SD.
Characteristics of Children Included in Study, Stratified by Maternal Thyroid Function in Early Pregnancy
| Characteristic . | No Maternal Thyroid Dysfunctiona . | Maternal Thyroid Dysfunctionb . |
|---|---|---|
| Children (n) | 1,008 | 145 |
| Birth year of the child | ||
| 1997–2000 | 503 (49.9) | 69 (47.6) |
| 2001–2003 | 505 (50.1) | 76 (52.4) |
| Child’s sex | ||
| Female | 475 (47.1) | 74 (51.0) |
| Male | 533 (52.9) | 71 (49.0) |
| Gestational age at birth | ||
| <37 wk | 25 (2.5) | 4 (2.8) |
| ≥37 wk | 983 (97.5) | 141 (97.2) |
| Birth weightc | ||
| <2500 g | 10 (1.0) | 3 (2.1) |
| ≥2500 g | 996 (99.0) | 142 (97.9) |
| 5-min Apgar scorec | ||
| 7–10 | 992 (99.4) | 145 (100.0) |
| 0–6 | 6 (0.6) | 0 (0) |
| Maternal parityc | ||
| Nulliparous | 533 (54.1) | 73 (52.1) |
| Multiparous | 453 (45.9) | 67 (47.9) |
| Maternal age | ||
| <30 y | 439 (43.6) | 68 (46.9) |
| ≥30 y | 569 (56.4) | 77 (53.1) |
| Maternal prepregnancy BMIc,d | ||
| <25 kg/m2 | 741 (75.3) | 96 (68.1) |
| ≥25 kg/m2 | 243 (24.7) | 45 (31.9) |
| Maternal smoking in pregnancyc,d | ||
| Yes | 329 (32.6) | 46 (31.7) |
| No | 679 (67.4) | 99 (68.3) |
| Maternal alcohol intake in pregnancyd | ||
| 0 units/wk | 455 (45.1) | 84 (57.9) |
| 1-4 units/wk | 439 (43.6) | 47 (32.4) |
| ≥5 units/wk | 114 (11.3) | 14 (9.7) |
| Maternal psychiatric diseased | ||
| Yes | 102 (10.1) | 13 (9.0) |
| No | 906 (89.9) | 132 (91.0) |
| Maternal IQe | ||
| Abnormal low | 150 (14.9) | 29 (20.0) |
| Normal | 858 (85.1) | 116 (80.0) |
| Parental educational levelc | ||
| <12 y | 267 (26.7) | 51 (35.2) |
| ≥12 y | 735 (73.3) | 94 (64.8) |
| Characteristic . | No Maternal Thyroid Dysfunctiona . | Maternal Thyroid Dysfunctionb . |
|---|---|---|
| Children (n) | 1,008 | 145 |
| Birth year of the child | ||
| 1997–2000 | 503 (49.9) | 69 (47.6) |
| 2001–2003 | 505 (50.1) | 76 (52.4) |
| Child’s sex | ||
| Female | 475 (47.1) | 74 (51.0) |
| Male | 533 (52.9) | 71 (49.0) |
| Gestational age at birth | ||
| <37 wk | 25 (2.5) | 4 (2.8) |
| ≥37 wk | 983 (97.5) | 141 (97.2) |
| Birth weightc | ||
| <2500 g | 10 (1.0) | 3 (2.1) |
| ≥2500 g | 996 (99.0) | 142 (97.9) |
| 5-min Apgar scorec | ||
| 7–10 | 992 (99.4) | 145 (100.0) |
| 0–6 | 6 (0.6) | 0 (0) |
| Maternal parityc | ||
| Nulliparous | 533 (54.1) | 73 (52.1) |
| Multiparous | 453 (45.9) | 67 (47.9) |
| Maternal age | ||
| <30 y | 439 (43.6) | 68 (46.9) |
| ≥30 y | 569 (56.4) | 77 (53.1) |
| Maternal prepregnancy BMIc,d | ||
| <25 kg/m2 | 741 (75.3) | 96 (68.1) |
| ≥25 kg/m2 | 243 (24.7) | 45 (31.9) |
| Maternal smoking in pregnancyc,d | ||
| Yes | 329 (32.6) | 46 (31.7) |
| No | 679 (67.4) | 99 (68.3) |
| Maternal alcohol intake in pregnancyd | ||
| 0 units/wk | 455 (45.1) | 84 (57.9) |
| 1-4 units/wk | 439 (43.6) | 47 (32.4) |
| ≥5 units/wk | 114 (11.3) | 14 (9.7) |
| Maternal psychiatric diseased | ||
| Yes | 102 (10.1) | 13 (9.0) |
| No | 906 (89.9) | 132 (91.0) |
| Maternal IQe | ||
| Abnormal low | 150 (14.9) | 29 (20.0) |
| Normal | 858 (85.1) | 116 (80.0) |
| Parental educational levelc | ||
| <12 y | 267 (26.7) | 51 (35.2) |
| ≥12 y | 735 (73.3) | 94 (64.8) |
Numbers are n (%).
TSH and fT4 between the pregnancy week–specific 2.5th and 97.5th percentiles.
TSH and/or fT4 outside the pregnancy week–specific 2.5th and 97.5th percentiles.
Individuals with missing values not included in the table.
Self-reported in the pregnancy.
Abnormal IQ defined by a score below the sample mean minus 1 SD.
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