Table 5. Open in new tab...

Models and Adjustments
Total T	427	0.88	0.73, 1.06	0.181	0.85	0.69, 1.03	0.107	0.87	0.70, 1.07	0.183	0.87	0.69, 1.09	0.215
fT	427	1.09	0.90, 1.32	0.385	0.89	0.72, 1.10	0.290	0.89	0.71, 1.11	0.319	0.90	0.71, 1.13	0.349
DHT	428	0.91	0.75, 1.10	0.322	0.92	0.75, 1.12	0.413	0.94	0.76, 1.16	0.589	0.96	0.77, 1.21	0.764
E₂^a	428	0.74	0.61, 0.89	0.002	0.81	0.64, 1.01	0.061	0.71	0.56, 0.91	0.008	0.68	0.52, 0.88	0.004
SHBG	429	0.76	0.63, 0.92	0.006	0.88	0.72, 1.08	0.223	0.90	0.72, 1.12	0.343	0.91	0.72, 1.15	0.446
FSH	429	0.88	0.76, 1.02	0.095	0.99	0.85, 1.15	0.906	1.02	0.88, 1.18	0.804	1.02	0.88, 1.19	0.791
LH	428	0.80	0.67, 0.96	0.018	0.91	0.76, 1.09	0.302	0.94	0.79, 1.12	0.484	0.94	0.79, 1.12	0.492

Models and Adjustments

Baseline Parameter

Model 1 Baseline Frailty

Model 2 Baseline Frailty and Age

Model 3 Baseline Frailty, Age, Center, Smoking

Model 4 Baseline Frailty, Age, Center, Smoking, BMIc

95% CI

P Value

95% CI

P Value

95% CI

P Value

95% CI

P Value

Total T

427

0.88

0.73, 1.06

0.181

0.85

0.69, 1.03

0.107

0.87

0.70, 1.07

0.183

0.87

0.69, 1.09

0.215

427

1.09

0.90, 1.32

0.385

0.89

0.72, 1.10

0.290

0.89

0.71, 1.11

0.319

0.90

0.71, 1.13

0.349

DHT

428

0.91

0.75, 1.10

0.322

0.92

0.75, 1.12

0.413

0.94

0.76, 1.16

0.589

0.96

0.77, 1.21

0.764

E₂^a

428

0.74

0.61, 0.89

0.002

0.81

0.64, 1.01

0.061

0.71

0.56, 0.91

0.008

0.68

0.52, 0.88

0.004

SHBG

429

0.76

0.63, 0.92

0.006

0.88

0.72, 1.08

0.223

0.90

0.72, 1.12

0.343

0.91

0.72, 1.15

0.446

FSH

429

0.88

0.76, 1.02

0.095

0.99

0.85, 1.15

0.906

1.02

0.88, 1.18

0.804

1.02

0.88, 1.19

0.791

428

0.80

0.67, 0.96

0.018

0.91

0.76, 1.09

0.302

0.94

0.79, 1.12

0.484

0.94

0.79, 1.12

0.492

Models and Adjustments
Total T	427	0.88	0.73, 1.06	0.181	0.85	0.69, 1.03	0.107	0.87	0.70, 1.07	0.183	0.87	0.69, 1.09	0.215
fT	427	1.09	0.90, 1.32	0.385	0.89	0.72, 1.10	0.290	0.89	0.71, 1.11	0.319	0.90	0.71, 1.13	0.349
DHT	428	0.91	0.75, 1.10	0.322	0.92	0.75, 1.12	0.413	0.94	0.76, 1.16	0.589	0.96	0.77, 1.21	0.764
E₂^a	428	0.74	0.61, 0.89	0.002	0.81	0.64, 1.01	0.061	0.71	0.56, 0.91	0.008	0.68	0.52, 0.88	0.004
SHBG	429	0.76	0.63, 0.92	0.006	0.88	0.72, 1.08	0.223	0.90	0.72, 1.12	0.343	0.91	0.72, 1.15	0.446
FSH	429	0.88	0.76, 1.02	0.095	0.99	0.85, 1.15	0.906	1.02	0.88, 1.18	0.804	1.02	0.88, 1.19	0.791
LH	428	0.80	0.67, 0.96	0.018	0.91	0.76, 1.09	0.302	0.94	0.79, 1.12	0.484	0.94	0.79, 1.12	0.492

Table 5.

Open in new tab

Multivariable-Adjusted OR (95% CI) for Improving FP Associated With Baseline Endocrine Predictors

Models and Adjustments
Baseline Parameter	N	Model 1 Baseline Frailty			Model 2 Baseline Frailty and Age			Model 3 Baseline Frailty, Age, Center, Smoking			Model 4 Baseline Frailty, Age, Center, Smoking, BMIc
Baseline Parameter	N	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value
Total T	427	0.88	0.73, 1.06	0.181	0.85	0.69, 1.03	0.107	0.87	0.70, 1.07	0.183	0.87	0.69, 1.09	0.215
fT	427	1.09	0.90, 1.32	0.385	0.89	0.72, 1.10	0.290	0.89	0.71, 1.11	0.319	0.90	0.71, 1.13	0.349
DHT	428	0.91	0.75, 1.10	0.322	0.92	0.75, 1.12	0.413	0.94	0.76, 1.16	0.589	0.96	0.77, 1.21	0.764
E₂^a	428	0.74	0.61, 0.89	0.002	0.81	0.64, 1.01	0.061	0.71	0.56, 0.91	0.008	0.68	0.52, 0.88	0.004
SHBG	429	0.76	0.63, 0.92	0.006	0.88	0.72, 1.08	0.223	0.90	0.72, 1.12	0.343	0.91	0.72, 1.15	0.446
FSH	429	0.88	0.76, 1.02	0.095	0.99	0.85, 1.15	0.906	1.02	0.88, 1.18	0.804	1.02	0.88, 1.19	0.791
LH	428	0.80	0.67, 0.96	0.018	0.91	0.76, 1.09	0.302	0.94	0.79, 1.12	0.484	0.94	0.79, 1.12	0.492

Models and Adjustments
Baseline Parameter	N	Model 1 Baseline Frailty			Model 2 Baseline Frailty and Age			Model 3 Baseline Frailty, Age, Center, Smoking			Model 4 Baseline Frailty, Age, Center, Smoking, BMIc
Baseline Parameter	N	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value
Total T	427	0.88	0.73, 1.06	0.181	0.85	0.69, 1.03	0.107	0.87	0.70, 1.07	0.183	0.87	0.69, 1.09	0.215
fT	427	1.09	0.90, 1.32	0.385	0.89	0.72, 1.10	0.290	0.89	0.71, 1.11	0.319	0.90	0.71, 1.13	0.349
DHT	428	0.91	0.75, 1.10	0.322	0.92	0.75, 1.12	0.413	0.94	0.76, 1.16	0.589	0.96	0.77, 1.21	0.764
E₂^a	428	0.74	0.61, 0.89	0.002	0.81	0.64, 1.01	0.061	0.71	0.56, 0.91	0.008	0.68	0.52, 0.88	0.004
SHBG	429	0.76	0.63, 0.92	0.006	0.88	0.72, 1.08	0.223	0.90	0.72, 1.12	0.343	0.91	0.72, 1.15	0.446
FSH	429	0.88	0.76, 1.02	0.095	0.99	0.85, 1.15	0.906	1.02	0.88, 1.18	0.804	1.02	0.88, 1.19	0.791
LH	428	0.80	0.67, 0.96	0.018	0.91	0.76, 1.09	0.302	0.94	0.79, 1.12	0.484	0.94	0.79, 1.12	0.492

Abbreviations: BMIc, BMI categories (<25, 25 to 30, ≥30); DM, diabetes mellitus; N, sample size.

Models 2 to 4 additionally adjusted for baseline total T level.

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