Multivariable-Adjusted OR (95% CI) for Worsening FP Associated With Baseline Endocrine Predictors
| Models and Adjustments . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Parameter . | N . | Model 1 Baseline Frailty . | Model 2 Baseline Frailty and Age . | Model 3 Baseline Frailty, Age, Center, Smoking . | Model 4 Baseline Frailty, Age, Center, Smoking, BMIc . | ||||||||
| OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | ||
| Total T | 1766 | 1.04 | 0.93, 1.16 | 0.446 | 1.04 | 0.93, 1.16 | 0.520 | 1.08 | 0.96, 1.22 | 0.187 | 1.05 | 0.92, 1.18 | 0.474 |
| fT | 1760 | 0.86 | 0.77, 0.96 | 0.008 | 0.98 | 0.87, 1.1 | 0.702 | 1.03 | 0.91, 1.16 | 0.681 | 0.99 | 0.88, 0.04 | 0.979 |
| DHT | 1759 | 1.07 | 0.96, 1.19 | 0.213 | 1.03 | 0.92, 1.15 | 0.601 | 1.01 | 0.90, 1.14 | 0.822 | 0.96 | 0.85, 1.09 | 0.574 |
| E2a | 1759 | 1.04 | 0.94, 1.16 | 0.435 | 0.99 | 0.87, 1.13 | 0.894 | 1.07 | 0.94, 1.23 | 0.300 | 1.11 | 0.97, 1.28 | 0.136 |
| SHBG | 1769 | 1.25 | 1.12, 1.39 | <0.001 | 1.08 | 0.96, 1.22 | 0.181 | 1.10 | 0.97, 1.24 | 0.144 | 1.06 | 0.94, 1.21 | 0.342 |
| FSH | 1768 | 1.21 | 1.09, 1.34 | <0.001 | 1.09 | 0.98, 1.22 | 0.123 | 1.11 | 0.99, 1.24 | 0.085 | 1.10 | 0.98, 1.24 | 0.094 |
| LH | 1767 | 1.20 | 1.08, 1.33 | 0.001 | 1.09 | 0.97, 1.22 | 0.132 | 1.08 | 0.96, 0.21 | 0.183 | 1.07 | 0.95, 1.20 | 0.257 |
| Models and Adjustments . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Parameter . | N . | Model 1 Baseline Frailty . | Model 2 Baseline Frailty and Age . | Model 3 Baseline Frailty, Age, Center, Smoking . | Model 4 Baseline Frailty, Age, Center, Smoking, BMIc . | ||||||||
| OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | ||
| Total T | 1766 | 1.04 | 0.93, 1.16 | 0.446 | 1.04 | 0.93, 1.16 | 0.520 | 1.08 | 0.96, 1.22 | 0.187 | 1.05 | 0.92, 1.18 | 0.474 |
| fT | 1760 | 0.86 | 0.77, 0.96 | 0.008 | 0.98 | 0.87, 1.1 | 0.702 | 1.03 | 0.91, 1.16 | 0.681 | 0.99 | 0.88, 0.04 | 0.979 |
| DHT | 1759 | 1.07 | 0.96, 1.19 | 0.213 | 1.03 | 0.92, 1.15 | 0.601 | 1.01 | 0.90, 1.14 | 0.822 | 0.96 | 0.85, 1.09 | 0.574 |
| E2a | 1759 | 1.04 | 0.94, 1.16 | 0.435 | 0.99 | 0.87, 1.13 | 0.894 | 1.07 | 0.94, 1.23 | 0.300 | 1.11 | 0.97, 1.28 | 0.136 |
| SHBG | 1769 | 1.25 | 1.12, 1.39 | <0.001 | 1.08 | 0.96, 1.22 | 0.181 | 1.10 | 0.97, 1.24 | 0.144 | 1.06 | 0.94, 1.21 | 0.342 |
| FSH | 1768 | 1.21 | 1.09, 1.34 | <0.001 | 1.09 | 0.98, 1.22 | 0.123 | 1.11 | 0.99, 1.24 | 0.085 | 1.10 | 0.98, 1.24 | 0.094 |
| LH | 1767 | 1.20 | 1.08, 1.33 | 0.001 | 1.09 | 0.97, 1.22 | 0.132 | 1.08 | 0.96, 0.21 | 0.183 | 1.07 | 0.95, 1.20 | 0.257 |
Abbreviations: BMIc, BMI categories (<25, 25 to 30, ≥30); DM, diabetes mellitus; N, sample size.
Models 2 to 4 additionally adjusted for baseline total T level.
Multivariable-Adjusted OR (95% CI) for Worsening FP Associated With Baseline Endocrine Predictors
| Models and Adjustments . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Parameter . | N . | Model 1 Baseline Frailty . | Model 2 Baseline Frailty and Age . | Model 3 Baseline Frailty, Age, Center, Smoking . | Model 4 Baseline Frailty, Age, Center, Smoking, BMIc . | ||||||||
| OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | ||
| Total T | 1766 | 1.04 | 0.93, 1.16 | 0.446 | 1.04 | 0.93, 1.16 | 0.520 | 1.08 | 0.96, 1.22 | 0.187 | 1.05 | 0.92, 1.18 | 0.474 |
| fT | 1760 | 0.86 | 0.77, 0.96 | 0.008 | 0.98 | 0.87, 1.1 | 0.702 | 1.03 | 0.91, 1.16 | 0.681 | 0.99 | 0.88, 0.04 | 0.979 |
| DHT | 1759 | 1.07 | 0.96, 1.19 | 0.213 | 1.03 | 0.92, 1.15 | 0.601 | 1.01 | 0.90, 1.14 | 0.822 | 0.96 | 0.85, 1.09 | 0.574 |
| E2a | 1759 | 1.04 | 0.94, 1.16 | 0.435 | 0.99 | 0.87, 1.13 | 0.894 | 1.07 | 0.94, 1.23 | 0.300 | 1.11 | 0.97, 1.28 | 0.136 |
| SHBG | 1769 | 1.25 | 1.12, 1.39 | <0.001 | 1.08 | 0.96, 1.22 | 0.181 | 1.10 | 0.97, 1.24 | 0.144 | 1.06 | 0.94, 1.21 | 0.342 |
| FSH | 1768 | 1.21 | 1.09, 1.34 | <0.001 | 1.09 | 0.98, 1.22 | 0.123 | 1.11 | 0.99, 1.24 | 0.085 | 1.10 | 0.98, 1.24 | 0.094 |
| LH | 1767 | 1.20 | 1.08, 1.33 | 0.001 | 1.09 | 0.97, 1.22 | 0.132 | 1.08 | 0.96, 0.21 | 0.183 | 1.07 | 0.95, 1.20 | 0.257 |
| Models and Adjustments . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Parameter . | N . | Model 1 Baseline Frailty . | Model 2 Baseline Frailty and Age . | Model 3 Baseline Frailty, Age, Center, Smoking . | Model 4 Baseline Frailty, Age, Center, Smoking, BMIc . | ||||||||
| OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | OR . | 95% CI . | P Value . | ||
| Total T | 1766 | 1.04 | 0.93, 1.16 | 0.446 | 1.04 | 0.93, 1.16 | 0.520 | 1.08 | 0.96, 1.22 | 0.187 | 1.05 | 0.92, 1.18 | 0.474 |
| fT | 1760 | 0.86 | 0.77, 0.96 | 0.008 | 0.98 | 0.87, 1.1 | 0.702 | 1.03 | 0.91, 1.16 | 0.681 | 0.99 | 0.88, 0.04 | 0.979 |
| DHT | 1759 | 1.07 | 0.96, 1.19 | 0.213 | 1.03 | 0.92, 1.15 | 0.601 | 1.01 | 0.90, 1.14 | 0.822 | 0.96 | 0.85, 1.09 | 0.574 |
| E2a | 1759 | 1.04 | 0.94, 1.16 | 0.435 | 0.99 | 0.87, 1.13 | 0.894 | 1.07 | 0.94, 1.23 | 0.300 | 1.11 | 0.97, 1.28 | 0.136 |
| SHBG | 1769 | 1.25 | 1.12, 1.39 | <0.001 | 1.08 | 0.96, 1.22 | 0.181 | 1.10 | 0.97, 1.24 | 0.144 | 1.06 | 0.94, 1.21 | 0.342 |
| FSH | 1768 | 1.21 | 1.09, 1.34 | <0.001 | 1.09 | 0.98, 1.22 | 0.123 | 1.11 | 0.99, 1.24 | 0.085 | 1.10 | 0.98, 1.24 | 0.094 |
| LH | 1767 | 1.20 | 1.08, 1.33 | 0.001 | 1.09 | 0.97, 1.22 | 0.132 | 1.08 | 0.96, 0.21 | 0.183 | 1.07 | 0.95, 1.20 | 0.257 |
Abbreviations: BMIc, BMI categories (<25, 25 to 30, ≥30); DM, diabetes mellitus; N, sample size.
Models 2 to 4 additionally adjusted for baseline total T level.
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