Brain Regions with Significant VMHC Differences between Patients with and Healthy Controls
| Brain Regions . | VMHC values (mean ± SD) . | Number of voxels . | t . | p values . | Peak MNI coordinate . | |||
|---|---|---|---|---|---|---|---|---|
| AOS . | HC . | X . | Y . | Z . | ||||
| Decreased (Patients < Controls) | ||||||||
| Fusiform Gyrus | 0.352 ± 0.201 | 0.557 ± 0.217 | 68 | -3.8871 | <0.000 | ±36 | -54 | -15 |
| Superior Temporal Gyrus/Insula | 0.358 ± 0.158 | 0.577 ± 0.278 | 86 | -4.6346 | <0.000 | ±45 | -18 | 12 |
| Precentral Gyrus | 0.392 ± 0.193 | 0.596 ± 0.218 | 116 | -3.9172 | <0.000 | ±60 | 0 | 24 |
| Precuneus | 0.614 ± 0.195 | 0.816 ± 0.214 | 62 | -4.2486 | <0.000 | ±9 | -48 | 45 |
| Brain Regions . | VMHC values (mean ± SD) . | Number of voxels . | t . | p values . | Peak MNI coordinate . | |||
|---|---|---|---|---|---|---|---|---|
| AOS . | HC . | X . | Y . | Z . | ||||
| Decreased (Patients < Controls) | ||||||||
| Fusiform Gyrus | 0.352 ± 0.201 | 0.557 ± 0.217 | 68 | -3.8871 | <0.000 | ±36 | -54 | -15 |
| Superior Temporal Gyrus/Insula | 0.358 ± 0.158 | 0.577 ± 0.278 | 86 | -4.6346 | <0.000 | ±45 | -18 | 12 |
| Precentral Gyrus | 0.392 ± 0.193 | 0.596 ± 0.218 | 116 | -3.9172 | <0.000 | ±60 | 0 | 24 |
| Precuneus | 0.614 ± 0.195 | 0.816 ± 0.214 | 62 | -4.2486 | <0.000 | ±9 | -48 | 45 |
Abbreviations: AOS, adolescent-onset schizophrenia; HC, healthy control; VMHC, voxel-mirrored homotopic connectivity.
The level of significance was set at the corrected P<.005 level using the Gaussian random field correction method at the cluster level (voxel significance: P<.001, cluster significance: P<.005).
Brain Regions with Significant VMHC Differences between Patients with and Healthy Controls
| Brain Regions . | VMHC values (mean ± SD) . | Number of voxels . | t . | p values . | Peak MNI coordinate . | |||
|---|---|---|---|---|---|---|---|---|
| AOS . | HC . | X . | Y . | Z . | ||||
| Decreased (Patients < Controls) | ||||||||
| Fusiform Gyrus | 0.352 ± 0.201 | 0.557 ± 0.217 | 68 | -3.8871 | <0.000 | ±36 | -54 | -15 |
| Superior Temporal Gyrus/Insula | 0.358 ± 0.158 | 0.577 ± 0.278 | 86 | -4.6346 | <0.000 | ±45 | -18 | 12 |
| Precentral Gyrus | 0.392 ± 0.193 | 0.596 ± 0.218 | 116 | -3.9172 | <0.000 | ±60 | 0 | 24 |
| Precuneus | 0.614 ± 0.195 | 0.816 ± 0.214 | 62 | -4.2486 | <0.000 | ±9 | -48 | 45 |
| Brain Regions . | VMHC values (mean ± SD) . | Number of voxels . | t . | p values . | Peak MNI coordinate . | |||
|---|---|---|---|---|---|---|---|---|
| AOS . | HC . | X . | Y . | Z . | ||||
| Decreased (Patients < Controls) | ||||||||
| Fusiform Gyrus | 0.352 ± 0.201 | 0.557 ± 0.217 | 68 | -3.8871 | <0.000 | ±36 | -54 | -15 |
| Superior Temporal Gyrus/Insula | 0.358 ± 0.158 | 0.577 ± 0.278 | 86 | -4.6346 | <0.000 | ±45 | -18 | 12 |
| Precentral Gyrus | 0.392 ± 0.193 | 0.596 ± 0.218 | 116 | -3.9172 | <0.000 | ±60 | 0 | 24 |
| Precuneus | 0.614 ± 0.195 | 0.816 ± 0.214 | 62 | -4.2486 | <0.000 | ±9 | -48 | 45 |
Abbreviations: AOS, adolescent-onset schizophrenia; HC, healthy control; VMHC, voxel-mirrored homotopic connectivity.
The level of significance was set at the corrected P<.005 level using the Gaussian random field correction method at the cluster level (voxel significance: P<.001, cluster significance: P<.005).
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