Table 3. Open in new tab Baseline...

Baseline (n = 29)

6 Months (n = 27)

12 Months (n = 26)

18 Months (n = 23)

24 Months (n = 20)

Radius

Tt.Ar (mm²)

273 ± 60

0.0 ± 0.3%

+0.2 ± 1%

+0.1 ± 0.4%

0.0 ± 0.4%

Ct.Ar (mm²)

54 ± 14

+0.4 ± 3%

+0.4 ± 4%

+1.2 ± 3%

+1.1 ± 3%

Tb.Ar (mm²)

219 ± 56

−0.1 ± 1%

+0.2 ± 2%

−0.1 ± 1%

−0.3 ± 1%

Tt.BMD (mg HA/cm³)

264 ± 77

+1.1 ± 3%^a

+1.3 ± 4%^a

+2.5 ± 4%^b^,^c

+2.8 ± 4%^b^,^c^,^d

Ct.BMD (mg HA/cm³)

791 ± 74

+0.5 ± 3%

+0.2 ± 4%

+1.2 ± 3%

+1.5 ± 3%^a^,^d

Tb.BMD (mg HA/cm³)

122 ± 44

+1.7 ± 4%^a

+1.8 ± 4%^a

+3.4 ± 4%^b^,^c^,^d

+3.8 ± 5%^b^,^c^,^d

Ct.Th (mm)

0.87 ± 0.2

+0.2 ± 2%

+0.1 ± 2%

+0.8 ± 2%^e

+1.1 ± 2%^e

D_meta (mg HA/cm³)

185 ± 43

+1.0 ± 4%

+1.5 ± 4%^a

+1.8 ± 3%^a

+2.9 ± 4%^b

D_inn (mg HA/cm³)

79 ± 46

+5.3 ± 10%^a

+1.9 ± 10%

+7.3 ± 8%^c^,^d^,^e

+5.8 ± 9%^a^,^d

D_meta/inn

3.50 ± 3.6

−3.5 ± 8%

+0.6 ± 12%

−4.7 ± 6%^a

−2.5 ± 5%

BV/TV (%)

0.102 ± 0.04

+1.7 ± 4%^a

+1.8 ± 4%^a

+3.4 ± 4%^b^,^c^,^d

+3.8 ± 5%^b^,^c^,^d

Tb.N (1/mm)

1.77 ± 0.4

0.0 ± 10%

+1.7 ± 10%

+2.3 ± 8%

+3.6 ± 9%

Tb.Th (mm)

0.057 ± 0.01

+2.6 ± 8%

+0.7 ± 8%

+1.7 ± 8%

+0.5 ± 6%

Tb.Sp (mm)

0.548 ± 0.18

+0.7 ± 10%

−1.0 ± 9%

−1.8 ± 8%

−3.2 ± 9%

Tb.Sp.SD (mm)

0.297 ± 0.21

+0.8 ± 12%

−1.6 ± 11%

−0.2 ± 12%

−3.1 ± 11%

Ct.Po (%)

2.7 ± 2

+5.6 ± 21%

+4.9 ± 20%

+4.7 ± 20%

+5.7 ± 26%

Stiffness (N/mm)

37,142 ± 13,078

+4.2 ± 5%^e

+3.6 ± 7%^a

+6.0 ± 8%^b

+6.6 ± 6%^b

Failure load (N)

1567 ± 543

+4.0 ± 4%^b

+3.5 ± 5%^e

+5.6 ± 7%^b

+6.2 ± 6%^b^,^c^,^d

Tibia

Tt.Ar

785 ± 148

0.0 ± 0.1%

+0.1 ± 0.3%

0.0 ± 0.1%

0.0 ± 0.2%

Ct.Ar (mm²)

111 ± 32

+1.1 ± 3%

+1.9 ± 4%^e^,^c

+2.7 ± 5%^b^,^c

+4.5 ± 5%^b^,^c^,^d^,^f

Tb.Ar (mm²)

673 ± 147

−0.2 ± 1%

−0.4 ± 1%^a^,^c

−0.8 ± 1%^b^,^c^,^d^,^f

Tt.BMD (mg HA/cm³)

238 ± 52

+1.6 ± 2%^e

+2.3 ± 3%^b

+3.5 ± 4%^b^,^c

+4.4 ± 4%^b^,^c^,^d^,^f

Ct.BMD (mg HA/cm³)

720 ± 98

+0.9 ± 3%

+1.3 ± 3%^a

+3.0 ± 5%^b^,^d

+4.0 ± 4%^b^,^c^,^d

Tb.BMD (mg HA/cm³)

149 ± 33

+1.3 ± 2%^a

+1.7 ± 3%^e

+2.7 ± 3%^b^,^c

+3.2 ± 4%^b^,^c

Ct.Th (mm)

1.19 ± 0.3

+0.7 ± 2%

+0.9 ± 2%

+1.9 ± 3%^b^,^c^,^d

+2.0 ± 3%^b^,^c^,^d^,^f

D_meta (mg HA/cm³)

219 ± 37

+1.0 ± 2%^a

+1.3 ± 3%^e

+2.2 ± 3%^b^,^c

+2.4 ± 3%^b^,^c

D_inn (mg HA/cm³)

101 ± 35

+1.9 ± 3%^a

+2.3 ± 4%^e

+4.0 ± 5%^b^,^c

+4.9 ± 6%^b^,^c

D_meta/inn

2.43 ± 1.1

−0.9 ± 3%

−1.6 ± 4%^a

−2.1 ± 4%^e

BV/TV (%)

0.124 ± 0.03

+1.3 ± 2%^a

+1.7 ± 3%^e

+2.7 ± 3%^b^,^c

+3.2 ± 4%^b^,^c

Tb.N (1/mm)

1.92 ± 0.4

−3.1 ± 8%

−0.2 ± 11%^c

+0.8 ± 9%

+3.5 ± 9%^c^,^f

Tb.Th (mm)

0.065 ± 0.01

+5.0 ± 8%^e

+2.6 ± 10%

+2.6 ± 9%

+0.1 ± 8%^c

Tb.Sp (mm)

0.479 ± 0.12

+3.7 ± 8%^a

+0.9 ± 10%^c

−0.4 ± 8%^c

−3.2 ± 8%^c^,^f

Tb.Sp.SD (mm)

0.244 ± 0.14

+2.8 ± 10%

−1.0 ± 11%^c

−0.8 ± 9%

−4.1 ± 8%^c

Ct.Po (%)

7.9 ± 3

−1.6 ± 11%

−2.0 ± 8%

−3.5 ± 11%

+1.4 ± 10%^d

Stiffness (N/mm)

115,142 ± 37,247

4.2 ± 6%^b

5.1 ± 7%^b

4.6 ± 7%^b

4.7 ± 8%^e

Failure load (N)

4906 ± 1187

3.6 ± 5%^b

4.6 ± 6%^b

4.4 ± 6%^b

4.8 ± 7%^b

Baseline (n = 29)

6 Months (n = 27)

12 Months (n = 26)

18 Months (n = 23)

24 Months (n = 20)

Radius

Tt.Ar (mm²)

273 ± 60

0.0 ± 0.3%

+0.2 ± 1%

+0.1 ± 0.4%

0.0 ± 0.4%

Ct.Ar (mm²)

54 ± 14

+0.4 ± 3%

+0.4 ± 4%

+1.2 ± 3%

+1.1 ± 3%

Tb.Ar (mm²)

219 ± 56

−0.1 ± 1%

+0.2 ± 2%

−0.1 ± 1%

−0.3 ± 1%

Tt.BMD (mg HA/cm³)

264 ± 77

+1.1 ± 3%^a

+1.3 ± 4%^a

+2.5 ± 4%^b^,^c

+2.8 ± 4%^b^,^c^,^d

Ct.BMD (mg HA/cm³)

791 ± 74

+0.5 ± 3%

+0.2 ± 4%

+1.2 ± 3%

+1.5 ± 3%^a^,^d

Tb.BMD (mg HA/cm³)

122 ± 44

+1.7 ± 4%^a

+1.8 ± 4%^a

+3.4 ± 4%^b^,^c^,^d

+3.8 ± 5%^b^,^c^,^d

Ct.Th (mm)

0.87 ± 0.2

+0.2 ± 2%

+0.1 ± 2%

+0.8 ± 2%^e

+1.1 ± 2%^e

D_meta (mg HA/cm³)

185 ± 43

+1.0 ± 4%

+1.5 ± 4%^a

+1.8 ± 3%^a

+2.9 ± 4%^b

D_inn (mg HA/cm³)

79 ± 46

+5.3 ± 10%^a

+1.9 ± 10%

+7.3 ± 8%^c^,^d^,^e

+5.8 ± 9%^a^,^d

D_meta/inn

3.50 ± 3.6

−3.5 ± 8%

+0.6 ± 12%

−4.7 ± 6%^a

−2.5 ± 5%

BV/TV (%)

0.102 ± 0.04

+1.7 ± 4%^a

+1.8 ± 4%^a

+3.4 ± 4%^b^,^c^,^d

+3.8 ± 5%^b^,^c^,^d

Tb.N (1/mm)

1.77 ± 0.4

0.0 ± 10%

+1.7 ± 10%

+2.3 ± 8%

+3.6 ± 9%

Tb.Th (mm)

0.057 ± 0.01

+2.6 ± 8%

+0.7 ± 8%

+1.7 ± 8%

+0.5 ± 6%

Tb.Sp (mm)

0.548 ± 0.18

+0.7 ± 10%

−1.0 ± 9%

−1.8 ± 8%

−3.2 ± 9%

Tb.Sp.SD (mm)

0.297 ± 0.21

+0.8 ± 12%

−1.6 ± 11%

−0.2 ± 12%

−3.1 ± 11%

Ct.Po (%)

2.7 ± 2

+5.6 ± 21%

+4.9 ± 20%

+4.7 ± 20%

+5.7 ± 26%

Stiffness (N/mm)

37,142 ± 13,078

+4.2 ± 5%^e

+3.6 ± 7%^a

+6.0 ± 8%^b

+6.6 ± 6%^b

Failure load (N)

1567 ± 543

+4.0 ± 4%^b

+3.5 ± 5%^e

+5.6 ± 7%^b

+6.2 ± 6%^b^,^c^,^d

Tibia

Tt.Ar

785 ± 148

0.0 ± 0.1%

+0.1 ± 0.3%

0.0 ± 0.1%

0.0 ± 0.2%

Ct.Ar (mm²)

111 ± 32

+1.1 ± 3%

+1.9 ± 4%^e^,^c

+2.7 ± 5%^b^,^c

+4.5 ± 5%^b^,^c^,^d^,^f

Tb.Ar (mm²)

673 ± 147

−0.2 ± 1%

−0.4 ± 1%^a^,^c

−0.8 ± 1%^b^,^c^,^d^,^f

Tt.BMD (mg HA/cm³)

238 ± 52

+1.6 ± 2%^e

+2.3 ± 3%^b

+3.5 ± 4%^b^,^c

+4.4 ± 4%^b^,^c^,^d^,^f

Ct.BMD (mg HA/cm³)

720 ± 98

+0.9 ± 3%

+1.3 ± 3%^a

+3.0 ± 5%^b^,^d

+4.0 ± 4%^b^,^c^,^d

Tb.BMD (mg HA/cm³)

149 ± 33

+1.3 ± 2%^a

+1.7 ± 3%^e

+2.7 ± 3%^b^,^c

+3.2 ± 4%^b^,^c

Ct.Th (mm)

1.19 ± 0.3

+0.7 ± 2%

+0.9 ± 2%

+1.9 ± 3%^b^,^c^,^d

+2.0 ± 3%^b^,^c^,^d^,^f

D_meta (mg HA/cm³)

219 ± 37

+1.0 ± 2%^a

+1.3 ± 3%^e

+2.2 ± 3%^b^,^c

+2.4 ± 3%^b^,^c

D_inn (mg HA/cm³)

101 ± 35

+1.9 ± 3%^a

+2.3 ± 4%^e

+4.0 ± 5%^b^,^c

+4.9 ± 6%^b^,^c

D_meta/inn

2.43 ± 1.1

−0.9 ± 3%

−1.6 ± 4%^a

−2.1 ± 4%^e

BV/TV (%)

0.124 ± 0.03

+1.3 ± 2%^a

+1.7 ± 3%^e

+2.7 ± 3%^b^,^c

+3.2 ± 4%^b^,^c

Tb.N (1/mm)

1.92 ± 0.4

−3.1 ± 8%

−0.2 ± 11%^c

+0.8 ± 9%

+3.5 ± 9%^c^,^f

Tb.Th (mm)

0.065 ± 0.01

+5.0 ± 8%^e

+2.6 ± 10%

+2.6 ± 9%

+0.1 ± 8%^c

Tb.Sp (mm)

0.479 ± 0.12

+3.7 ± 8%^a

+0.9 ± 10%^c

−0.4 ± 8%^c

−3.2 ± 8%^c^,^f

Tb.Sp.SD (mm)

0.244 ± 0.14

+2.8 ± 10%

−1.0 ± 11%^c

−0.8 ± 9%

−4.1 ± 8%^c

Ct.Po (%)

7.9 ± 3

−1.6 ± 11%

−2.0 ± 8%

−3.5 ± 11%

+1.4 ± 10%^d

Stiffness (N/mm)

115,142 ± 37,247

4.2 ± 6%^b

5.1 ± 7%^b

4.6 ± 7%^b

4.7 ± 8%^e

Failure load (N)

4906 ± 1187

3.6 ± 5%^b

4.6 ± 6%^b

4.4 ± 6%^b

4.8 ± 7%^b

Table 3.

Open in new tab

Baseline High-Resolution Peripheral Quantitative Computed Tomography Parameters at the Radius and Tibia in the Primary Hyperparathyroid Cohort and Changes Through 2 Years After Parathyroidectomy

	Baseline (n = 29)	6 Months (n = 27)	12 Months (n = 26)	18 Months (n = 23)	24 Months (n = 20)
Radius
Tt.Ar (mm²)	273 ± 60	0.0 ± 0.3%	+0.2 ± 1%	+0.1 ± 0.4%	0.0 ± 0.4%
Ct.Ar (mm²)	54 ± 14	+0.4 ± 3%	+0.4 ± 4%	+1.2 ± 3%	+1.1 ± 3%
Tb.Ar (mm²)	219 ± 56	−0.1 ± 1%	+0.2 ± 2%	−0.1 ± 1%	−0.3 ± 1%
Tt.BMD (mg HA/cm³)	264 ± 77	+1.1 ± 3%^a	+1.3 ± 4%^a	+2.5 ± 4%^b^,^c	+2.8 ± 4%^b^,^c^,^d
Ct.BMD (mg HA/cm³)	791 ± 74	+0.5 ± 3%	+0.2 ± 4%	+1.2 ± 3%	+1.5 ± 3%^a^,^d
Tb.BMD (mg HA/cm³)	122 ± 44	+1.7 ± 4%^a	+1.8 ± 4%^a	+3.4 ± 4%^b^,^c^,^d	+3.8 ± 5%^b^,^c^,^d
Ct.Th (mm)	0.87 ± 0.2	+0.2 ± 2%	+0.1 ± 2%	+0.8 ± 2%^e	+1.1 ± 2%^e
D_meta (mg HA/cm³)	185 ± 43	+1.0 ± 4%	+1.5 ± 4%^a	+1.8 ± 3%^a	+2.9 ± 4%^b
D_inn (mg HA/cm³)	79 ± 46	+5.3 ± 10%^a	+1.9 ± 10%	+7.3 ± 8%^c^,^d^,^e	+5.8 ± 9%^a^,^d
D_meta/inn	3.50 ± 3.6	−3.5 ± 8%	+0.6 ± 12%	−4.7 ± 6%^a	−2.5 ± 5%
BV/TV (%)	0.102 ± 0.04	+1.7 ± 4%^a	+1.8 ± 4%^a	+3.4 ± 4%^b^,^c^,^d	+3.8 ± 5%^b^,^c^,^d
Tb.N (1/mm)	1.77 ± 0.4	0.0 ± 10%	+1.7 ± 10%	+2.3 ± 8%	+3.6 ± 9%
Tb.Th (mm)	0.057 ± 0.01	+2.6 ± 8%	+0.7 ± 8%	+1.7 ± 8%	+0.5 ± 6%
Tb.Sp (mm)	0.548 ± 0.18	+0.7 ± 10%	−1.0 ± 9%	−1.8 ± 8%	−3.2 ± 9%
Tb.Sp.SD (mm)	0.297 ± 0.21	+0.8 ± 12%	−1.6 ± 11%	−0.2 ± 12%	−3.1 ± 11%
Ct.Po (%)	2.7 ± 2	+5.6 ± 21%	+4.9 ± 20%	+4.7 ± 20%	+5.7 ± 26%
Stiffness (N/mm)	37,142 ± 13,078	+4.2 ± 5%^e	+3.6 ± 7%^a	+6.0 ± 8%^b	+6.6 ± 6%^b
Failure load (N)	1567 ± 543	+4.0 ± 4%^b	+3.5 ± 5%^e	+5.6 ± 7%^b	+6.2 ± 6%^b^,^c^,^d
Tibia
Tt.Ar	785 ± 148	0.0 ± 0.1%	+0.1 ± 0.3%	0.0 ± 0.1%	0.0 ± 0.2%
Ct.Ar (mm²)	111 ± 32	+1.1 ± 3%	+1.9 ± 4%^e^,^c	+2.7 ± 5%^b^,^c	+4.5 ± 5%^b^,^c^,^d^,^f
Tb.Ar (mm²)	673 ± 147	−0.2 ± 1%	−0.2 ± 1%	−0.4 ± 1%^a^,^c	−0.8 ± 1%^b^,^c^,^d^,^f
Tt.BMD (mg HA/cm³)	238 ± 52	+1.6 ± 2%^e	+2.3 ± 3%^b	+3.5 ± 4%^b^,^c	+4.4 ± 4%^b^,^c^,^d^,^f
Ct.BMD (mg HA/cm³)	720 ± 98	+0.9 ± 3%	+1.3 ± 3%^a	+3.0 ± 5%^b^,^d	+4.0 ± 4%^b^,^c^,^d
Tb.BMD (mg HA/cm³)	149 ± 33	+1.3 ± 2%^a	+1.7 ± 3%^e	+2.7 ± 3%^b^,^c	+3.2 ± 4%^b^,^c
Ct.Th (mm)	1.19 ± 0.3	+0.7 ± 2%	+0.9 ± 2%	+1.9 ± 3%^b^,^c^,^d	+2.0 ± 3%^b^,^c^,^d^,^f
D_meta (mg HA/cm³)	219 ± 37	+1.0 ± 2%^a	+1.3 ± 3%^e	+2.2 ± 3%^b^,^c	+2.4 ± 3%^b^,^c
D_inn (mg HA/cm³)	101 ± 35	+1.9 ± 3%^a	+2.3 ± 4%^e	+4.0 ± 5%^b^,^c	+4.9 ± 6%^b^,^c
D_meta/inn	2.43 ± 1.1	−0.9 ± 3%	−0.9 ± 3%	−1.6 ± 4%^a	−2.1 ± 4%^e
BV/TV (%)	0.124 ± 0.03	+1.3 ± 2%^a	+1.7 ± 3%^e	+2.7 ± 3%^b^,^c	+3.2 ± 4%^b^,^c
Tb.N (1/mm)	1.92 ± 0.4	−3.1 ± 8%	−0.2 ± 11%^c	+0.8 ± 9%	+3.5 ± 9%^c^,^f
Tb.Th (mm)	0.065 ± 0.01	+5.0 ± 8%^e	+2.6 ± 10%	+2.6 ± 9%	+0.1 ± 8%^c
Tb.Sp (mm)	0.479 ± 0.12	+3.7 ± 8%^a	+0.9 ± 10%^c	−0.4 ± 8%^c	−3.2 ± 8%^c^,^f
Tb.Sp.SD (mm)	0.244 ± 0.14	+2.8 ± 10%	−1.0 ± 11%^c	−0.8 ± 9%	−4.1 ± 8%^c
Ct.Po (%)	7.9 ± 3	−1.6 ± 11%	−2.0 ± 8%	−3.5 ± 11%	+1.4 ± 10%^d
Stiffness (N/mm)	115,142 ± 37,247	4.2 ± 6%^b	5.1 ± 7%^b	4.6 ± 7%^b	4.7 ± 8%^e
Failure load (N)	4906 ± 1187	3.6 ± 5%^b	4.6 ± 6%^b	4.4 ± 6%^b	4.8 ± 7%^b

	Baseline (n = 29)	6 Months (n = 27)	12 Months (n = 26)	18 Months (n = 23)	24 Months (n = 20)
Radius
Tt.Ar (mm²)	273 ± 60	0.0 ± 0.3%	+0.2 ± 1%	+0.1 ± 0.4%	0.0 ± 0.4%
Ct.Ar (mm²)	54 ± 14	+0.4 ± 3%	+0.4 ± 4%	+1.2 ± 3%	+1.1 ± 3%
Tb.Ar (mm²)	219 ± 56	−0.1 ± 1%	+0.2 ± 2%	−0.1 ± 1%	−0.3 ± 1%
Tt.BMD (mg HA/cm³)	264 ± 77	+1.1 ± 3%^a	+1.3 ± 4%^a	+2.5 ± 4%^b^,^c	+2.8 ± 4%^b^,^c^,^d
Ct.BMD (mg HA/cm³)	791 ± 74	+0.5 ± 3%	+0.2 ± 4%	+1.2 ± 3%	+1.5 ± 3%^a^,^d
Tb.BMD (mg HA/cm³)	122 ± 44	+1.7 ± 4%^a	+1.8 ± 4%^a	+3.4 ± 4%^b^,^c^,^d	+3.8 ± 5%^b^,^c^,^d
Ct.Th (mm)	0.87 ± 0.2	+0.2 ± 2%	+0.1 ± 2%	+0.8 ± 2%^e	+1.1 ± 2%^e
D_meta (mg HA/cm³)	185 ± 43	+1.0 ± 4%	+1.5 ± 4%^a	+1.8 ± 3%^a	+2.9 ± 4%^b
D_inn (mg HA/cm³)	79 ± 46	+5.3 ± 10%^a	+1.9 ± 10%	+7.3 ± 8%^c^,^d^,^e	+5.8 ± 9%^a^,^d
D_meta/inn	3.50 ± 3.6	−3.5 ± 8%	+0.6 ± 12%	−4.7 ± 6%^a	−2.5 ± 5%
BV/TV (%)	0.102 ± 0.04	+1.7 ± 4%^a	+1.8 ± 4%^a	+3.4 ± 4%^b^,^c^,^d	+3.8 ± 5%^b^,^c^,^d
Tb.N (1/mm)	1.77 ± 0.4	0.0 ± 10%	+1.7 ± 10%	+2.3 ± 8%	+3.6 ± 9%
Tb.Th (mm)	0.057 ± 0.01	+2.6 ± 8%	+0.7 ± 8%	+1.7 ± 8%	+0.5 ± 6%
Tb.Sp (mm)	0.548 ± 0.18	+0.7 ± 10%	−1.0 ± 9%	−1.8 ± 8%	−3.2 ± 9%
Tb.Sp.SD (mm)	0.297 ± 0.21	+0.8 ± 12%	−1.6 ± 11%	−0.2 ± 12%	−3.1 ± 11%
Ct.Po (%)	2.7 ± 2	+5.6 ± 21%	+4.9 ± 20%	+4.7 ± 20%	+5.7 ± 26%
Stiffness (N/mm)	37,142 ± 13,078	+4.2 ± 5%^e	+3.6 ± 7%^a	+6.0 ± 8%^b	+6.6 ± 6%^b
Failure load (N)	1567 ± 543	+4.0 ± 4%^b	+3.5 ± 5%^e	+5.6 ± 7%^b	+6.2 ± 6%^b^,^c^,^d
Tibia
Tt.Ar	785 ± 148	0.0 ± 0.1%	+0.1 ± 0.3%	0.0 ± 0.1%	0.0 ± 0.2%
Ct.Ar (mm²)	111 ± 32	+1.1 ± 3%	+1.9 ± 4%^e^,^c	+2.7 ± 5%^b^,^c	+4.5 ± 5%^b^,^c^,^d^,^f
Tb.Ar (mm²)	673 ± 147	−0.2 ± 1%	−0.2 ± 1%	−0.4 ± 1%^a^,^c	−0.8 ± 1%^b^,^c^,^d^,^f
Tt.BMD (mg HA/cm³)	238 ± 52	+1.6 ± 2%^e	+2.3 ± 3%^b	+3.5 ± 4%^b^,^c	+4.4 ± 4%^b^,^c^,^d^,^f
Ct.BMD (mg HA/cm³)	720 ± 98	+0.9 ± 3%	+1.3 ± 3%^a	+3.0 ± 5%^b^,^d	+4.0 ± 4%^b^,^c^,^d
Tb.BMD (mg HA/cm³)	149 ± 33	+1.3 ± 2%^a	+1.7 ± 3%^e	+2.7 ± 3%^b^,^c	+3.2 ± 4%^b^,^c
Ct.Th (mm)	1.19 ± 0.3	+0.7 ± 2%	+0.9 ± 2%	+1.9 ± 3%^b^,^c^,^d	+2.0 ± 3%^b^,^c^,^d^,^f
D_meta (mg HA/cm³)	219 ± 37	+1.0 ± 2%^a	+1.3 ± 3%^e	+2.2 ± 3%^b^,^c	+2.4 ± 3%^b^,^c
D_inn (mg HA/cm³)	101 ± 35	+1.9 ± 3%^a	+2.3 ± 4%^e	+4.0 ± 5%^b^,^c	+4.9 ± 6%^b^,^c
D_meta/inn	2.43 ± 1.1	−0.9 ± 3%	−0.9 ± 3%	−1.6 ± 4%^a	−2.1 ± 4%^e
BV/TV (%)	0.124 ± 0.03	+1.3 ± 2%^a	+1.7 ± 3%^e	+2.7 ± 3%^b^,^c	+3.2 ± 4%^b^,^c
Tb.N (1/mm)	1.92 ± 0.4	−3.1 ± 8%	−0.2 ± 11%^c	+0.8 ± 9%	+3.5 ± 9%^c^,^f
Tb.Th (mm)	0.065 ± 0.01	+5.0 ± 8%^e	+2.6 ± 10%	+2.6 ± 9%	+0.1 ± 8%^c
Tb.Sp (mm)	0.479 ± 0.12	+3.7 ± 8%^a	+0.9 ± 10%^c	−0.4 ± 8%^c	−3.2 ± 8%^c^,^f
Tb.Sp.SD (mm)	0.244 ± 0.14	+2.8 ± 10%	−1.0 ± 11%^c	−0.8 ± 9%	−4.1 ± 8%^c
Ct.Po (%)	7.9 ± 3	−1.6 ± 11%	−2.0 ± 8%	−3.5 ± 11%	+1.4 ± 10%^d
Stiffness (N/mm)	115,142 ± 37,247	4.2 ± 6%^b	5.1 ± 7%^b	4.6 ± 7%^b	4.7 ± 8%^e
Failure load (N)	4906 ± 1187	3.6 ± 5%^b	4.6 ± 6%^b	4.4 ± 6%^b	4.8 ± 7%^b

D_meta/inn, the radio of meta to inner trabecular density; Tb.Ar, trabecular area; Tb.BMD, trabecular volumetric bone mineral density; Tt.Ar, total area.

P < 0.05 compared with baseline.

P < 0.001 compared with baseline.

P < 0.05 compared with 6 months.

P < 0.05 compared with 12 months.

P < 0.01 compared with baseline.

P < 0.05 compared with 18 months.

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