HR of Infection-Related Mortality: the Atherosclerosis Risk in Communities Study, 1990 to 2013
| Variable . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . |
|---|---|---|---|---|
| FGF23, pg/mL | ||||
| Range | <33.8 | 33.8–41.7 | 41.7–51.4 | ≥51.4 |
| Deaths/persons | 219/2802 | 204/2808 | 256/2816 | 306/2792 |
| Mortality rate per 1000 person-years | 4.0 (3.5–4.6) | 3.7 (3.2–4.3) | 4.7 (4.1–5.3) | 5.9 (5.2–6.6) |
| Age-, sex-, and race-adjusted HR | 1.12 (0.92–1.35) | 1 (Reference) | 1.21 (1.01–1.46) | 1.48 (1.24–1.77) |
| Fully adjusted HR | 1.08 (0.89–1.31) | 1 (Reference) | 1.16 (0.96–1.39) | 1.25 (1.04–1.50) |
| 25(OH)D, ng/mL | ||||
| Range | <18.5 | 18.5–23.8 | 23.8–29.6 | ≥29.6 |
| Deaths/persons | 284/2768 | 222/2779 | 243/2835 | 236/2836 |
| Mortality rate per 1000 person-years | 5.5 (4.9–6.2) | 4.1 (3.6–4.7) | 4.4 (3.9–5.0) | 4.2 (3.7–4.8) |
| Age-, sex-, and race-adjusted HR | 1.51 (1.26–1.80) | 1 (Reference) | 1.03 (0.86–1.24) | 0.96 (0.80–1.16) |
| Fully adjusted HR | 1.36 (1.14–1.63) | 1 (Reference) | 1.03 (0.86–1.24) | 0.95 (0.79–1.15) |
| PTH, pg/mL | ||||
| Range | <31.2 | 31.2–39.2 | 39.2–49.1 | ≥49.1 |
| Deaths/persons | 245/2785 | 234/2811 | 256/2836 | 250/2786 |
| Mortality rate per 1000 person-years | 4.6 (4.1–5.2) | 4.2 (3.7–4.8) | 4.7 (4.1–5.3) | 4.7 (4.1–5.3) |
| Age-, sex-, and race-adjusted HR | 1.15 (0.96–1.38) | 1 (Reference) | 1.09 (0.91–1.30) | 1.03 (0.86–1.24) |
| Fully adjusted HR | 1.12 (0.93–1.34) | 1 (Reference) | 1.08 (0.90–1.29) | 0.97 (0.81–1.16) |
| Corrected calcium (mg/dL) | ||||
| Range | <9.1 | 9.1–9.4 | 9.4–9.6 | ≥9.6 |
| Deaths/persons | 172/2281 | 268/3209 | 189/2214 | 356/3514 |
| Mortality rate per 1000 person-years | 3.9 (3.3–4.5) | 4.3 (3.8–4.9) | 4.4 (3.8–5.1) | 5.3 (4.8–5.9) |
| Age-, sex-, and race-adjusted HR | 0.94 (0.77–1.14) | 1 (Reference) | 1.01 (0.84–1.22) | 1.21 (1.03–1.42) |
| Fully adjusted HR | 0.96 (0.80–1.17) | 1 (Reference) | 1.04 (0.86–1.25) | 1.20 (1.02–1.42) |
| Phosphorus, mg/dL | ||||
| Range | <3.2 | 3.2–3.5 | 3.5–3.8 | ≥3.8 |
| Deaths/persons | 218/2392 | 240/2585 | 281/3456 | 246/2785 |
| Mortality rate per 1000 person-years | 4.8 (4.2–5.4) | 4.9 (4.3–5.5) | 4.2 (3.7–4.7) | 4.6 (4.0–5.2) |
| Age-, sex-, and race-adjusted HR | 0.90 (0.75–1.08) | 1 (Reference) | 0.90 (0.76–1.07) | 1.04 (0.87–1.26) |
| Fully adjusted HR | 0.86 (0.72–1.04) | 1 (Reference) | 0.94 (0.79–1.12) | 1.04 (0.86–1.25) |
| Variable . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . |
|---|---|---|---|---|
| FGF23, pg/mL | ||||
| Range | <33.8 | 33.8–41.7 | 41.7–51.4 | ≥51.4 |
| Deaths/persons | 219/2802 | 204/2808 | 256/2816 | 306/2792 |
| Mortality rate per 1000 person-years | 4.0 (3.5–4.6) | 3.7 (3.2–4.3) | 4.7 (4.1–5.3) | 5.9 (5.2–6.6) |
| Age-, sex-, and race-adjusted HR | 1.12 (0.92–1.35) | 1 (Reference) | 1.21 (1.01–1.46) | 1.48 (1.24–1.77) |
| Fully adjusted HR | 1.08 (0.89–1.31) | 1 (Reference) | 1.16 (0.96–1.39) | 1.25 (1.04–1.50) |
| 25(OH)D, ng/mL | ||||
| Range | <18.5 | 18.5–23.8 | 23.8–29.6 | ≥29.6 |
| Deaths/persons | 284/2768 | 222/2779 | 243/2835 | 236/2836 |
| Mortality rate per 1000 person-years | 5.5 (4.9–6.2) | 4.1 (3.6–4.7) | 4.4 (3.9–5.0) | 4.2 (3.7–4.8) |
| Age-, sex-, and race-adjusted HR | 1.51 (1.26–1.80) | 1 (Reference) | 1.03 (0.86–1.24) | 0.96 (0.80–1.16) |
| Fully adjusted HR | 1.36 (1.14–1.63) | 1 (Reference) | 1.03 (0.86–1.24) | 0.95 (0.79–1.15) |
| PTH, pg/mL | ||||
| Range | <31.2 | 31.2–39.2 | 39.2–49.1 | ≥49.1 |
| Deaths/persons | 245/2785 | 234/2811 | 256/2836 | 250/2786 |
| Mortality rate per 1000 person-years | 4.6 (4.1–5.2) | 4.2 (3.7–4.8) | 4.7 (4.1–5.3) | 4.7 (4.1–5.3) |
| Age-, sex-, and race-adjusted HR | 1.15 (0.96–1.38) | 1 (Reference) | 1.09 (0.91–1.30) | 1.03 (0.86–1.24) |
| Fully adjusted HR | 1.12 (0.93–1.34) | 1 (Reference) | 1.08 (0.90–1.29) | 0.97 (0.81–1.16) |
| Corrected calcium (mg/dL) | ||||
| Range | <9.1 | 9.1–9.4 | 9.4–9.6 | ≥9.6 |
| Deaths/persons | 172/2281 | 268/3209 | 189/2214 | 356/3514 |
| Mortality rate per 1000 person-years | 3.9 (3.3–4.5) | 4.3 (3.8–4.9) | 4.4 (3.8–5.1) | 5.3 (4.8–5.9) |
| Age-, sex-, and race-adjusted HR | 0.94 (0.77–1.14) | 1 (Reference) | 1.01 (0.84–1.22) | 1.21 (1.03–1.42) |
| Fully adjusted HR | 0.96 (0.80–1.17) | 1 (Reference) | 1.04 (0.86–1.25) | 1.20 (1.02–1.42) |
| Phosphorus, mg/dL | ||||
| Range | <3.2 | 3.2–3.5 | 3.5–3.8 | ≥3.8 |
| Deaths/persons | 218/2392 | 240/2585 | 281/3456 | 246/2785 |
| Mortality rate per 1000 person-years | 4.8 (4.2–5.4) | 4.9 (4.3–5.5) | 4.2 (3.7–4.7) | 4.6 (4.0–5.2) |
| Age-, sex-, and race-adjusted HR | 0.90 (0.75–1.08) | 1 (Reference) | 0.90 (0.76–1.07) | 1.04 (0.87–1.26) |
| Fully adjusted HR | 0.86 (0.72–1.04) | 1 (Reference) | 0.94 (0.79–1.12) | 1.04 (0.86–1.25) |
Analysis was based on 985 infection-related deaths, defined as death occurring during or within 30 days of hospitalization with infection. Fully adjusted models adjusted for age, sex, race, body mass index, smoking, alcohol consumption, years of education, serum albumin, hsCRP, medication use (vitamin D, calcium, steroids, and antineoplastic agents), diabetes, hypertension, history of cancer, COPD, coronary heart disease, stroke, and eGFR. Levels of 25(OH)D were adjusted to account for seasonality. Corrected calcium (mg/dL) = serum calcium (mg/dL) + 0.8 × (4.0 − serum albumin in g/dL) if serum albumin <4.0 g/dL.
HR of Infection-Related Mortality: the Atherosclerosis Risk in Communities Study, 1990 to 2013
| Variable . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . |
|---|---|---|---|---|
| FGF23, pg/mL | ||||
| Range | <33.8 | 33.8–41.7 | 41.7–51.4 | ≥51.4 |
| Deaths/persons | 219/2802 | 204/2808 | 256/2816 | 306/2792 |
| Mortality rate per 1000 person-years | 4.0 (3.5–4.6) | 3.7 (3.2–4.3) | 4.7 (4.1–5.3) | 5.9 (5.2–6.6) |
| Age-, sex-, and race-adjusted HR | 1.12 (0.92–1.35) | 1 (Reference) | 1.21 (1.01–1.46) | 1.48 (1.24–1.77) |
| Fully adjusted HR | 1.08 (0.89–1.31) | 1 (Reference) | 1.16 (0.96–1.39) | 1.25 (1.04–1.50) |
| 25(OH)D, ng/mL | ||||
| Range | <18.5 | 18.5–23.8 | 23.8–29.6 | ≥29.6 |
| Deaths/persons | 284/2768 | 222/2779 | 243/2835 | 236/2836 |
| Mortality rate per 1000 person-years | 5.5 (4.9–6.2) | 4.1 (3.6–4.7) | 4.4 (3.9–5.0) | 4.2 (3.7–4.8) |
| Age-, sex-, and race-adjusted HR | 1.51 (1.26–1.80) | 1 (Reference) | 1.03 (0.86–1.24) | 0.96 (0.80–1.16) |
| Fully adjusted HR | 1.36 (1.14–1.63) | 1 (Reference) | 1.03 (0.86–1.24) | 0.95 (0.79–1.15) |
| PTH, pg/mL | ||||
| Range | <31.2 | 31.2–39.2 | 39.2–49.1 | ≥49.1 |
| Deaths/persons | 245/2785 | 234/2811 | 256/2836 | 250/2786 |
| Mortality rate per 1000 person-years | 4.6 (4.1–5.2) | 4.2 (3.7–4.8) | 4.7 (4.1–5.3) | 4.7 (4.1–5.3) |
| Age-, sex-, and race-adjusted HR | 1.15 (0.96–1.38) | 1 (Reference) | 1.09 (0.91–1.30) | 1.03 (0.86–1.24) |
| Fully adjusted HR | 1.12 (0.93–1.34) | 1 (Reference) | 1.08 (0.90–1.29) | 0.97 (0.81–1.16) |
| Corrected calcium (mg/dL) | ||||
| Range | <9.1 | 9.1–9.4 | 9.4–9.6 | ≥9.6 |
| Deaths/persons | 172/2281 | 268/3209 | 189/2214 | 356/3514 |
| Mortality rate per 1000 person-years | 3.9 (3.3–4.5) | 4.3 (3.8–4.9) | 4.4 (3.8–5.1) | 5.3 (4.8–5.9) |
| Age-, sex-, and race-adjusted HR | 0.94 (0.77–1.14) | 1 (Reference) | 1.01 (0.84–1.22) | 1.21 (1.03–1.42) |
| Fully adjusted HR | 0.96 (0.80–1.17) | 1 (Reference) | 1.04 (0.86–1.25) | 1.20 (1.02–1.42) |
| Phosphorus, mg/dL | ||||
| Range | <3.2 | 3.2–3.5 | 3.5–3.8 | ≥3.8 |
| Deaths/persons | 218/2392 | 240/2585 | 281/3456 | 246/2785 |
| Mortality rate per 1000 person-years | 4.8 (4.2–5.4) | 4.9 (4.3–5.5) | 4.2 (3.7–4.7) | 4.6 (4.0–5.2) |
| Age-, sex-, and race-adjusted HR | 0.90 (0.75–1.08) | 1 (Reference) | 0.90 (0.76–1.07) | 1.04 (0.87–1.26) |
| Fully adjusted HR | 0.86 (0.72–1.04) | 1 (Reference) | 0.94 (0.79–1.12) | 1.04 (0.86–1.25) |
| Variable . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . |
|---|---|---|---|---|
| FGF23, pg/mL | ||||
| Range | <33.8 | 33.8–41.7 | 41.7–51.4 | ≥51.4 |
| Deaths/persons | 219/2802 | 204/2808 | 256/2816 | 306/2792 |
| Mortality rate per 1000 person-years | 4.0 (3.5–4.6) | 3.7 (3.2–4.3) | 4.7 (4.1–5.3) | 5.9 (5.2–6.6) |
| Age-, sex-, and race-adjusted HR | 1.12 (0.92–1.35) | 1 (Reference) | 1.21 (1.01–1.46) | 1.48 (1.24–1.77) |
| Fully adjusted HR | 1.08 (0.89–1.31) | 1 (Reference) | 1.16 (0.96–1.39) | 1.25 (1.04–1.50) |
| 25(OH)D, ng/mL | ||||
| Range | <18.5 | 18.5–23.8 | 23.8–29.6 | ≥29.6 |
| Deaths/persons | 284/2768 | 222/2779 | 243/2835 | 236/2836 |
| Mortality rate per 1000 person-years | 5.5 (4.9–6.2) | 4.1 (3.6–4.7) | 4.4 (3.9–5.0) | 4.2 (3.7–4.8) |
| Age-, sex-, and race-adjusted HR | 1.51 (1.26–1.80) | 1 (Reference) | 1.03 (0.86–1.24) | 0.96 (0.80–1.16) |
| Fully adjusted HR | 1.36 (1.14–1.63) | 1 (Reference) | 1.03 (0.86–1.24) | 0.95 (0.79–1.15) |
| PTH, pg/mL | ||||
| Range | <31.2 | 31.2–39.2 | 39.2–49.1 | ≥49.1 |
| Deaths/persons | 245/2785 | 234/2811 | 256/2836 | 250/2786 |
| Mortality rate per 1000 person-years | 4.6 (4.1–5.2) | 4.2 (3.7–4.8) | 4.7 (4.1–5.3) | 4.7 (4.1–5.3) |
| Age-, sex-, and race-adjusted HR | 1.15 (0.96–1.38) | 1 (Reference) | 1.09 (0.91–1.30) | 1.03 (0.86–1.24) |
| Fully adjusted HR | 1.12 (0.93–1.34) | 1 (Reference) | 1.08 (0.90–1.29) | 0.97 (0.81–1.16) |
| Corrected calcium (mg/dL) | ||||
| Range | <9.1 | 9.1–9.4 | 9.4–9.6 | ≥9.6 |
| Deaths/persons | 172/2281 | 268/3209 | 189/2214 | 356/3514 |
| Mortality rate per 1000 person-years | 3.9 (3.3–4.5) | 4.3 (3.8–4.9) | 4.4 (3.8–5.1) | 5.3 (4.8–5.9) |
| Age-, sex-, and race-adjusted HR | 0.94 (0.77–1.14) | 1 (Reference) | 1.01 (0.84–1.22) | 1.21 (1.03–1.42) |
| Fully adjusted HR | 0.96 (0.80–1.17) | 1 (Reference) | 1.04 (0.86–1.25) | 1.20 (1.02–1.42) |
| Phosphorus, mg/dL | ||||
| Range | <3.2 | 3.2–3.5 | 3.5–3.8 | ≥3.8 |
| Deaths/persons | 218/2392 | 240/2585 | 281/3456 | 246/2785 |
| Mortality rate per 1000 person-years | 4.8 (4.2–5.4) | 4.9 (4.3–5.5) | 4.2 (3.7–4.7) | 4.6 (4.0–5.2) |
| Age-, sex-, and race-adjusted HR | 0.90 (0.75–1.08) | 1 (Reference) | 0.90 (0.76–1.07) | 1.04 (0.87–1.26) |
| Fully adjusted HR | 0.86 (0.72–1.04) | 1 (Reference) | 0.94 (0.79–1.12) | 1.04 (0.86–1.25) |
Analysis was based on 985 infection-related deaths, defined as death occurring during or within 30 days of hospitalization with infection. Fully adjusted models adjusted for age, sex, race, body mass index, smoking, alcohol consumption, years of education, serum albumin, hsCRP, medication use (vitamin D, calcium, steroids, and antineoplastic agents), diabetes, hypertension, history of cancer, COPD, coronary heart disease, stroke, and eGFR. Levels of 25(OH)D were adjusted to account for seasonality. Corrected calcium (mg/dL) = serum calcium (mg/dL) + 0.8 × (4.0 − serum albumin in g/dL) if serum albumin <4.0 g/dL.
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