2025 Paper of the Year
Craniofacial anomalies are one of the most frequent birth defects worldwide and are often caused by genetic and environmental factors such as pharmaceuticals and chemical agents. Although identifying adverse outcome pathways (AOPs) is a central issue for evaluating the teratogenicity, the AOP ...
Latest articles
Safety attrition due to drug-induced inotropic changes remains a significant risk factor for drug development. Mitigating these events during early screening remains challenging. Several in vitro predictive models have been developed to address these issues, with varying success in detecting ...
Following an observation of myocardial toxicity in rats with an experimental TYK2 inhibitor (ABBV-712), investigative studies were performed to identify the mechanism. Telemetry-instrumented rats were administered ABBV-712 with or without atenolol to investigate effects of co-dosing on hemodynamic ...
ToxSpotlight
Traditional approaches for quantitatively characterizing uncertainty in risk assessment require adaptation to accommodate increased reliance on observational (vs experimental) studies in developing toxicity values. Herein, a case study with perfluorooctanoic acid (PFOA) and PFOS and vaccine ...
Titanium dioxide nanoparticles (TiO 2 NPs) are among the most widely produced metallic NPs due to commercial and industrial applications in products including food, cosmetics, paints, and plastics. TiO 2 NPs are released into the environment posing health risks for humans and wildlife. Widespread ...
The Society of Toxicology 2024 meeting assembled risk assessors, epidemiologists, and toxicologists to discuss the utility of integrating epidemiologic data into the derivation of reference values. Advantages of the use of epidemiologic evidence include (i) human relevance; (ii) increased ...
The waste generated from cement manufacturing is an important source of heavy metal contamination of groundwater and soil. This study investigated the concentration of toxic metals in the soil of a major cement factory and nearby groundwater. Ecological and carcinogenic risks of the metals were ...
Plasma half-life is a crucial pharmacokinetic parameter for estimating extralabel withdrawal intervals of drugs to ensure the safety of food products derived from animals. This study focuses on developing a quantitative structure–activity relationship (QSAR) model incorporating multiple machine ...
Per- and polyfluoroalkyl substances (PFAS) are a diverse class of anthropogenic chemicals; many are persistent, bioaccumulative, and mobile in the environment. Worldwide, PFAS bioaccumulation causes serious adverse health impacts, yet the physiochemical determinants of bioaccumulation and toxicity ...
Editor-in-Chief
Jeffrey M. Peters
Impact Factor
3.4
CiteScore
8.6
Author Information
Call for Papers
The mission of Toxicological Sciences is to publish a broad spectrum of impactful research in the field of toxicology. We are inviting all experts in the Society of Toxicology and beyond to submit their insightful and timely research articles, of which the journal is currently particularly interested in studies addressing the following:
- The mechanistic role of microbiome(s) in modulating toxicity caused by environmental chemical exposure
- Studies examining the impact of microplastics on cell function and toxicity
- Utility of artificial intelligence in predictive toxicology
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