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Journal Article

Combined Administration of RG7652, a Recombinant Human Monoclonal Antibody Against PCSK9, and Atorvastatin Does Not Result in Reduction of Immune Function Get access

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Thomas R. Gelzleichter and others

Toxicological Sciences, Volume 140, Issue 2, August 2014, Pages 470–480, https://doi.org/10.1093/toxsci/kfu093

Published: 02 August 2014

Journal Article

Lipopolysaccharide-Induced microRNA-146a Targets CARD10 and Regulates Angiogenesis in Human Umbilical Vein Endothelial Cells Get access

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Cheng-Shyuan Rau and others

Toxicological Sciences, Volume 140, Issue 2, August 2014, Pages 315–326, https://doi.org/10.1093/toxsci/kfu097

Published: 02 August 2014

Journal Article

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

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Ian M. Copple and others

Toxicological Sciences, Volume 140, Issue 2, August 2014, Pages 462–469, https://doi.org/10.1093/toxsci/kfu080

Published: 02 August 2014

Supplementary data

Journal Article

Cross-Linking of β-Lactoglobulin Enhances Allergic Sensitization Through Changes in Cellular Uptake and Processing Get access

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Marija Stojadinovic and others

Toxicological Sciences, Volume 140, Issue 1, July 2014, Pages 224–235, https://doi.org/10.1093/toxsci/kfu062

Published: 17 April 2014

Supplementary data

Journal Article

Integrated Preclinical Photosafety Testing Strategy for Systemically Applied Pharmaceuticals Get access

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Jens Schümann and others

Toxicological Sciences, Volume 139, Issue 1, May 2014, Pages 245–256, https://doi.org/10.1093/toxsci/kfu026

Published: 21 February 2014

Journal Article

Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors: Analysis of Their Human Relevance Using the IPCS Framework

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Christian Strupp and others

Toxicological Sciences, Volume 128, Issue 1, July 2012, Pages 284–294, https://doi.org/10.1093/toxsci/kfs127

Published: 05 April 2012

Journal Article

Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model Get access

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Jin Hyen Baek and others

Toxicological Sciences, Volume 127, Issue 2, June 2012, Pages 567–581, https://doi.org/10.1093/toxsci/kfs109

Published: 12 March 2012

Journal Article

Rat-Specific Decreases in Platelet Count Caused by a Humanized Monoclonal Antibody Against Sclerostin Get access

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Daniel G. Rudmann and others

Toxicological Sciences, Volume 125, Issue 2, February 2012, Pages 586–594, https://doi.org/10.1093/toxsci/kfr318

Published: 21 November 2011

Journal Article

A Selective Akt Inhibitor Produces Hypotension and Bradycardia in Conscious Rats Due to Inhibition of the Autonomic Nervous System Get access

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Jonathan P. Renninger and others

Toxicological Sciences, Volume 125, Issue 2, February 2012, Pages 578–585, https://doi.org/10.1093/toxsci/kfr316

Published: 16 November 2011

Journal Article

Nonclinical Evaluation of GMA161—An Antihuman CD16 (FcγRIII) Monoclonal Antibody for Treatment of Autoimmune Disorders in CD16 Transgenic Mice Get access

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Meghan M. Flaherty and others

Toxicological Sciences, Volume 125, Issue 1, January 2012, Pages 299–309, https://doi.org/10.1093/toxsci/kfr278

Published: 24 October 2011

Journal Article

Toxicogenomics and Metabolomics of Pentamethylchromanol (PMCol)-Induced Hepatotoxicity Get access

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Toufan Parman and others

Toxicological Sciences, Volume 124, Issue 2, December 2011, Pages 487–501, https://doi.org/10.1093/toxsci/kfr238

Published: 13 September 2011

Supplementary data

Journal Article

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Get access

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Liang Guo and others

Toxicological Sciences, Volume 123, Issue 1, September 2011, Pages 281–289, https://doi.org/10.1093/toxsci/kfr158

Published: 20 June 2011

Supplementary data

Journal Article

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study Get access

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N. A. Monteiro-Riviere and others

Toxicological Sciences, Volume 123, Issue 1, September 2011, Pages 264–280, https://doi.org/10.1093/toxsci/kfr148

Published: 03 June 2011

Journal Article

A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents

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Jeffrey L. Larson and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 567–578, https://doi.org/10.1093/toxsci/kfr109

Published: 13 May 2011

Journal Article

Hepatic Cytochrome P450s Attenuate the Cytotoxicity Induced by Leflunomide and Its Active Metabolite A77 1726 in Primary Cultured Rat Hepatocytes Get access

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Qiang Shi and others

Toxicological Sciences, Volume 122, Issue 2, August 2011, Pages 579–586, https://doi.org/10.1093/toxsci/kfr106

Published: 04 May 2011

Journal Article

The Use of Surrogate Antibodies to Evaluate the Developmental and Reproductive Toxicity Potential of an Anti-TNFα PEGylated Fab′ Monoclonal Antibody Get access

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Ian Wakefield and others

Toxicological Sciences, Volume 122, Issue 1, July 2011, Pages 170–176, https://doi.org/10.1093/toxsci/kfr083

Published: 19 April 2011

Journal Article

Oversulfated Chondroitin Sulfate and OSCS-Contaminated Heparin Cause Dose- and Route-Dependent Hemodynamic Effects in the Rat Get access

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Alain Corbier and others

Toxicological Sciences, Volume 121, Issue 2, June 2011, Pages 417–427, https://doi.org/10.1093/toxsci/kfr072

Published: 24 March 2011

Journal Article

Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats Get access

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Cristina C. Jacob and others

Toxicological Sciences, Volume 119, Issue 2, February 2011, Pages 391–397, https://doi.org/10.1093/toxsci/kfq333

Published: 28 October 2010

Supplementary data

Journal Article

Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors Get access

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Andrew J. Olaharski and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 266–275, https://doi.org/10.1093/toxsci/kfq258

Published: 01 September 2010

Supplementary data

Journal Article

A Novel Framework for Predicting In Vivo Toxicities from In Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression Get access

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Peter A. DiMaggio and others

Toxicological Sciences, Volume 118, Issue 1, November 2010, Pages 251–265, https://doi.org/10.1093/toxsci/kfq233

Published: 11 August 2010

Supplementary data

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Combined Administration of RG7652, a Recombinant Human Monoclonal Antibody Against PCSK9, and Atorvastatin Does Not Result in Reduction of Immune Function Get access

Lipopolysaccharide-Induced microRNA-146a Targets CARD10 and Regulates Angiogenesis in Human Umbilical Vein Endothelial Cells Get access

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids

Cross-Linking of β-Lactoglobulin Enhances Allergic Sensitization Through Changes in Cellular Uptake and Processing Get access

Integrated Preclinical Photosafety Testing Strategy for Systemically Applied Pharmaceuticals Get access

Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors: Analysis of Their Human Relevance Using the IPCS Framework

Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model Get access

Rat-Specific Decreases in Platelet Count Caused by a Humanized Monoclonal Antibody Against Sclerostin Get access

A Selective Akt Inhibitor Produces Hypotension and Bradycardia in Conscious Rats Due to Inhibition of the Autonomic Nervous System Get access

Nonclinical Evaluation of GMA161—An Antihuman CD16 (FcγRIII) Monoclonal Antibody for Treatment of Autoimmune Disorders in CD16 Transgenic Mice Get access

Toxicogenomics and Metabolomics of Pentamethylchromanol (PMCol)-Induced Hepatotoxicity Get access

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Get access

Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study Get access

A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents

Hepatic Cytochrome P450s Attenuate the Cytotoxicity Induced by Leflunomide and Its Active Metabolite A77 1726 in Primary Cultured Rat Hepatocytes Get access

The Use of Surrogate Antibodies to Evaluate the Developmental and Reproductive Toxicity Potential of an Anti-TNFα PEGylated Fab′ Monoclonal Antibody Get access

Oversulfated Chondroitin Sulfate and OSCS-Contaminated Heparin Cause Dose- and Route-Dependent Hemodynamic Effects in the Rat Get access

Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats Get access

Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors Get access

A Novel Framework for Predicting In Vivo Toxicities from In Vitro Data Using Optimal Methods for Dense and Sparse Matrix Reordering and Logistic Regression Get access

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